Individualized in-hospital exercise training program for people undergoing hematopoietic stem cell transplantation: a feasibility study

Fioritto, Aline Priori; Oliveira, Cristino Carneiro; Albuquerque1, Vanessa Salles; Almeida, Leonardo Barbosa de; Granger, Catherine L; Denehy, Linda; Malaguti, Carla

doi:10.1080/09638288.2019.1626493

Cited by 15 publications

(15 citation statements)

References 26 publications

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“…Despite the original step test protocols that were developed to evaluate athletes and healthy individuals, its use has now been validated in older adults and different clinical populations, such as those with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cardiovascular diseases, stroke, and patients undergoing bone marrow transplantation [8][9][10][11][12][13] . The 6MST is described in the literature using protocols that differ by step height, rhythm, and cadence 14 .…”

Section: Introductionmentioning

confidence: 99%

Performance, metabolic, hemodynamic, and perceived exertion in the six-minute step test at different heights in a healthy population of different age groups

Oliveira

Albuquerque1

et al. 2021

Motriz: rev. educ. fis.

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This study aimed to compare the performance, metabolic, hemodynamic, and perceived exertion during the 6-minute step test (6MST) conducted with different step heights in healthy subjects and also to compare the performance between different age groups for each step height. The association between age, body mass index, level of physical activity, and lower limb measurements with performance were also evaluated. Methods: This is a cross-sectional study. Anthropometric measures, physical performance, and cardiovascular stress were evaluated during a selfpaced 6MST with different step heights in healthy subjects in the age group of 18-59. All the participants underwent three-step tests (15 cm, 20 cm, and 30 cm) on the same day, in a randomized order. Results: Forty participants (20 men and 20 women) performed the tests. The performance in the test for the highest step was significantly lower compared to the step with the lowest height (152 ± 24 vs. 173 ± 27 and 184 ± 33; p < 0,05). The estimated peak oxygen consumption (VO 2peak ) increased by ∼2.5 mL.kg −1 •min −1 with the increase in step height. Hemodynamic variables, such as percent of maximum heart rate (%HR máx ), and systolic blood pressure increased as the step height increased. There was a fair correlation between performance and the level of physical activity in the test with a step height of 15 cm and 20 cm. Conclusion:A higher step height caused greater cardiovascular stress, without exceeding the submaximal levels of the test, indicating that the 6MST can be used as an accurate instrument for evaluating aerobic capacity in healthy individuals.

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Section: Introductionmentioning

confidence: 99%

Performance, metabolic, hemodynamic, and perceived exertion in the six-minute step test at different heights in a healthy population of different age groups

Oliveira

Albuquerque1

et al. 2021

Motriz: rev. educ. fis.

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“…With outcomes focused on fatigue, fitness, and QOL, the trends suggest that exercise can be beneficial, supporting the current guideline in that exercise may have a multimodal positive or neutral effect throughout the deconditioning process. 37 , 39–41 These recent findings further extend our understanding that this patient population requires highly individualized exercise to optimize their treatment pathway. In terms of new research, a study found that inspiratory muscle training plus conventional physical therapy may aid with reduced negative symptoms (ie, less need for oxygen therapy) compared with conventional physical therapy alone.…”

Section: New and Current Researchmentioning

confidence: 66%

“…With regards to feasibility, multiple studies deemed exercise pre-treatment and during medical treatment to be successful (excellent adherence rate, no adverse events), particularly as a positive emotional impact prior to the deconditioning. 36 , 38 , 39 , 41 Other studies assessing exercise during and post medical treatment focused highly on individualized exercise in which daily laboratory values were utilized to make exercise adjustments. With outcomes focused on fatigue, fitness, and QOL, the trends suggest that exercise can be beneficial, supporting the current guideline in that exercise may have a multimodal positive or neutral effect throughout the deconditioning process.…”

Section: New and Current Researchmentioning

confidence: 99%

Mobilization and Exercise Intervention for Patients With Multiple Myeloma: Clinical Practice Guidelines Endorsed by the Canadian Physiotherapy Association

et al. 2020

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Objective Individuals with multiple myeloma (MM) often have reduced functional performance due to the cancer itself or as a direct side effect of cancer treatments. Physical therapy is a part of cancer rehabilitation; however, no guidelines are available to provide information and direction for physical therapists managing patients with MM. The goal of this guideline is to provide recommendations based on a systematic review and consensus process that physical therapists can use to manage patients with MM. Methods A systematic review of the literature published until August 2018 was performed in eight databases with two independent reviewers assessing quality. Seventeen articles were identified as relevant and a draft guideline was developed in the form of action statements. A total of 10 physical therapists with hematology experience and 10 patients with MM were recruited for consensus process. A priori threshold of 80% agreement was used to establish a consensus for each statement. The draft guidelines were reviewed externally by four methodologists using the AGREE II tool and a stakeholder representing OH (Cancer Care Ontario) Program in Evidence Based Care (PEBC), McMaster University. The final guideline was reviewed and officially endorsed by the Canadian Physiotherapy Association. Results A total of 30 action statements were developed that achieved consensus, indicating physical therapy recommendations based on physiological markers (ie, hemoglobin, platelet count), complete patient presentation, and the stage of medical treatment. Conclusion These clinical practice guidelines were developed to aid physical therapists in implementing evidence-based and best-practice care for patients with MM in order to optimize rehabilitation outcomes.

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“…The predominant type of HSCT was allogeneic (n = 41; 54%), being 30 related (39%) and 11 unrelated (15%), followed by autologous HSCT (n = 36; 46%). A total of 1341 days of physiotherapy sessions were analysed in a median hospital length of stay of 30 [23][24][25][26][27][28][29][30][31][32][33][34][35] days. The patients presented 1315 (98%) days of physiotherapy sessions with aerobic exercises, 1287 (96%) with resistance exercises, 36 (2.7%) with active exercises, 18 (1.3%) passive exercises, and 1341 (100%) with stretching exercises.…”

Section: Resultsmentioning

confidence: 99%

“…In our study, we showed that the bleeding frequency is low without highly severe events. The physical exercise practice is important to enhance the gain or maintenance of muscle strength and functionality during the hospital stay in patients undergoing HSCT [35].…”

Section: Plos Onementioning

confidence: 99%

Bleeding frequency during physiotherapy in thrombocytopenic patients undergoing hematopoietic stem cell transplantation

et al. 2021

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Background During hematopoietic stem cell transplantation (HSCT) the patients perform activities of low and moderate intensity because have reduced hematological lineages, leaving them susceptible to hemorrhagic events. The objective of this study was to describe the frequency of bleeding events, severity, and possible association with physical exercise in thrombocytopenic patients. Methods A retrospective study with seventy-seven HSCT patients hospitalised, that had a platelet count ≤ 50,000 /μL and received physical exercise during physiotherapy intervention. Results Regarding bleeding events, only six were related to physical exercise, and bleeding events occurred more frequently at platelet levels ≤ 10,000 /μL. The most frequent bleeding event was epistaxis, considered of low severity, and with the moderate possibility of being related to physical exercise; followed by extremity hematoma, considered of medium severity and highly related to physical exercise. In this study, there was no occurrence of bleeding events considered of high severity. Conclusion Bleeding frequency in supervised physical exercise during physiotherapy in adults with thrombocytopenia undergoing HSCT is minor and relatively rare but occurs more frequently in patients with platelet count ≤10,000 /μL. These results encourage the maintenance of physical activity in this population who is at high risk of developing immobility-related complications.

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Individualized in-hospital exercise training program for people undergoing hematopoietic stem cell transplantation: a feasibility study

Cited by 15 publications

References 26 publications

Performance, metabolic, hemodynamic, and perceived exertion in the six-minute step test at different heights in a healthy population of different age groups

Performance, metabolic, hemodynamic, and perceived exertion in the six-minute step test at different heights in a healthy population of different age groups

Mobilization and Exercise Intervention for Patients With Multiple Myeloma: Clinical Practice Guidelines Endorsed by the Canadian Physiotherapy Association

Bleeding frequency during physiotherapy in thrombocytopenic patients undergoing hematopoietic stem cell transplantation

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