Individualized eHealth Support for Oncological Therapy Management

Schinköthe, Timo

doi:10.1159/000500900

Cited by 13 publications

(10 citation statements)

References 17 publications

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“…CANKADO is used for patient support throughout their treatment period and offers all treating physicians and oncology nurses the possibility to monitor their patients’ ePROs [16]. All collected data of CANKADO were evaluated with patients’ consent.…”

Section: Methodsmentioning

confidence: 99%

Biologically Based Complementary and Alternative Medicine Use in Breast Cancer Patients and Possible Drug-Drug Interactions

Debes¹,

König²,

Strobach³

et al. 2023

Breast Care

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Purpose: Biologically-based Complementary and Alternative Medicine (BB-CAM) is gaining importance. Cancer patients in particular are at risk of interactions between the prescribed medications (intravenous or oral anticancer therapy, concomitant medication, medication for pre-existing illnesses) and BB-CAM. This investigation aims to identify potentially clinically relevant interactions between both BB-CAM and conventional medicine and two BB-CAM products in breast cancer patients (n=47). Methods: From March 2020 to January 2021, consecutive breast cancer patients (n=47) completed a questionnaire about their medication and BB-CAM intake at the beginning of a new intravenous or oral tumor therapy (time point one) and again after ten to twelve weeks (time point two) at the LMU Breast Center in Munich. The collective was divided into two subgroups based on the time after initial diagnosis; a cut off-of six months was used. The survey was available through an eHealth application called CANKADO as ePRO (electronic patient-reported outcome) only. Lexicomp® and AiD Klinik® databases were used for evaluating for potentially clinically relevant interactions. As part of routine care, the collected data were evaluated and cross-checked in interdisciplinary cooperation with the University Hospital Pharmacy LMU. Results: 43 of the 47 included breast cancer patients (91%) used BB-CAM at some point during their treatment period. We found a significantl increase from time point one (n=27) to time point two (n=40) (p=0.004). Moreover, in the subgroup of newly diagnosed patients, the number significant rose from 17 at time point one to 28 at time point two (p=0.007). Overall, we found potentially clinically relevant interactions in 30 of 43 patients (70%). Sixty interactions were detected at both times of investigations. Twenty-three different kinds of BB-CAM-to-BB-CAM (time point one n=12, time point two n=11) or conventional medicine-to-BB-CAM interactions (time point one n= 15, time point two n= 22) were discovered. Importantly, there was not a single interaction between BB-CAM and an anticancer drug. Conclusion: Breast cancer patients frequently use BB-CAM. Interactions were detected at both time points of investigation (time point one n=27, time point two n=33). Interactions were particularly evident between BB-CAM substances as well as between BB-CAM and the patients' medication for pre-existing illnesses. Although no interaction between BB-CAM and an anticancer therapy was found, the use of BB-CAM should be evaluated at the beginning and regularly during therapy in view of the substantial number of interactions detected and the large number of upcoming targeted therapies.

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Section: Methodsmentioning

confidence: 99%

Biologically Based Complementary and Alternative Medicine Use in Breast Cancer Patients and Possible Drug-Drug Interactions

Debes¹,

König²,

Strobach³

et al. 2023

Breast Care

Self Cite

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“…eHealth tools provide a great opportunity to decrease the hospital length of stay and improve care for these survivors. In addition, after discharge, these tools can be used for symptom monitoring, physical activity tracking, psychological issues related to cancer, and nutrition management as well as undergoing a consultation from physicians and health care providers [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Smartphone Remote Monitoring App to Follow Up Colorectal Cancer Survivors: Requirement Analysis

Ayyoubzadeh¹,

Shirkhoda²,

Kalhori³

et al. 2022

JMIR Cancer

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Background Colorectal cancer survivors face multiple challenges after discharge. eHealth may potentially support them by providing tools such as smartphone apps. They have lots of capabilities to exchange information and could be used for remote monitoring of these patients. Objective In this study, we addressed the required features for apps designed to follow up colorectal cancer patients based on survivors’ and clinical experts’ views. Methods A mixed methods study was conducted. Features of related apps were extracted through the literature; the features were categorized, and then, they were modified. A questionnaire was designed containing the features listed and prioritized based on the MoSCoW (Must have, Should have, Could have, Won’t have) technique and an open question for each category. The link to the questionnaire was shared among clinical experts in Iran. The answers were analyzed using the content validity ratio (CVR), and based on the value of this measure, the minimum feature set of a monitoring app to follow up patients with colorectal cancer was addressed. In addition, a telephone interview with colorectal cancer survivors was conducted to collect their viewpoints regarding a remote monitoring system for colorectal cancer cases. Results The questionnaire contained 10 sections evaluating 9 categories of features. The questionnaire was completed by 18 experts. The minimum set of features in the app was identified as patient information registration, sign and symptom monitoring, education, reminders, and patient evaluation (0.42 < CVR < 0.85). Features including physical activity, personalized advice, and social network did not achieve the minimum score (–0.11 < CVR < 0.39). We interviewed 9 colorectal cancer survivors. Information registration, sign and symptom monitoring, education, and personalized advice were the features with high priority from the survivors’ perspectives. Scheduling, shopping, and financial support features were emphasized by survivors in the interview. Conclusions The requirement set could be used to design an app for the targeted population or patients affected by other cancers. As the views from both survivors and clinical experts were considered in this study, the remote system may more adequately fulfill the need for follow-up of survivors. This eases the patients’ and health care providers’ communication and interaction.

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“…In recent years, mobile web applications (apps) have increasingly been used to promote chronic disease management, including patients with cancer. [27][28][29] Regular reporting of a limited set of symptoms has been found to be an accurate and cost-effective way of detecting recurrences and treatmentrelated late effects in patients with cancer in the lungs and breasts. 30 31 Smartphone apps have also been used as tools to enhance physical function and physical activity in cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle and Empowerment Techniques in Survivorship of Gynaecologic Oncology (LETSGO study): a study protocol for a multicentre longitudinal interventional study using mobile health technology and biobanking

et al. 2021

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IntroductionThe number of gynaecological cancer survivors is increasing and there is a need for a more sustainable model of follow-up care. Today’s follow-up model is time-consuming and patients have reported unmet needs regarding information about their cancer and strategies for managing the consequences of treatment. The main aim of this study is to assess health-related empowerment—in terms of patient education, psychosocial support, and promotion of physical activity—in a new follow-up model by comparing it to standard follow-up in a quasi-randomised study involving intervention hospitals and control hospitals.Methods and analysisAt the intervention hospitals, patients will be stratified by risk of recurrence and late effects to either 1 or 3 years’ follow-up. Nurses will replace doctors in half of the follow-up visits and focus in particular on patient education, self-management and physical activity. They will provide patients with information and guide them in goal setting and action planning. These measures will be reinforced by a smartphone application for monitoring symptoms and promoting physical activity. At the control hospitals, patients will be included in the standard follow-up programme. All patients will be asked to complete questionnaires at baseline and after 3, 6, 12, 24 and 36 months. Blood samples will be collected for biobanking at 3, 12 and 36 months. The primary outcome is health-related empowerment. Secondary outcomes include health-related quality of life, adherence to physical activity recommendations, time to recurrence, healthcare costs and changes in biomarkers. Changes in these outcomes will be analysed using generalised linear mixed models for repeated measures. Type of hospital (intervention or control), time (measurement point), and possible confounders will be included as fixed factors.Ethics and disseminationThe study is approved by the Regional Committee for Medical Research Ethics (2019/11093). Dissemination of findings will occur at the local, national and international levels.Trial registration numberNCT04122235.

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Individualized eHealth Support for Oncological Therapy Management

Cited by 13 publications

References 17 publications

Biologically Based Complementary and Alternative Medicine Use in Breast Cancer Patients and Possible Drug-Drug Interactions

Biologically Based Complementary and Alternative Medicine Use in Breast Cancer Patients and Possible Drug-Drug Interactions

A Smartphone Remote Monitoring App to Follow Up Colorectal Cancer Survivors: Requirement Analysis

Lifestyle and Empowerment Techniques in Survivorship of Gynaecologic Oncology (LETSGO study): a study protocol for a multicentre longitudinal interventional study using mobile health technology and biobanking

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