Individualism and insulin pump therapy

Kerr, David

doi:10.1007/s00125-008-1228-0

Cited by 2 publications

(1 citation statement)

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“…This is accomplished by insulin schemes restoring physiological insulin secretion, thus controlling both baseline and postprandial glucose regulation. Therefore, the combinatorial scheme of long-acting basal insulin with rapid-acting analogues is becoming more popular [16]. In any case, it should be taken into account that poorly controlled patients need to manage fasting blood glucose (FBG) levels before postprandial glycaemias.…”

Section: Insulin Therapymentioning

confidence: 99%

Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps

Valla

2010

Experimental Diabetes Research

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Aim. Inadequately controlled diabetes accounts for chronic complications and increases mortality. Its therapeutic management aims in normal HbA1C, prandial and postprandial glucose levels. This review discusses diabetes management focusing on the latest insulin analogues, alternative insulin delivery systems and the artificial pancreas. Results. Intensive insulin therapy with multiple daily injections (MDI) allows better imitation of the physiological rhythm of insulin secretion. Longer-acting, basal insulin analogues provide concomitant improvements in safety, efficacy and variability of glycaemic control, followed by low risks of hypoglycaemia. Continuous subcutaneous insulin infusion (CSII) provides long-term glycaemic control especially in type 1 diabetic patients, while reducing hypoglycaemic episodes and glycaemic variability. Continuous subcutaneous glucose monitoring (CGM) systems provide information on postprandial glucose excursions and nocturnal hypo- and/or hyperglycemias. This information enhances treatment options, provides a useful tool for self-monitoring and allows safer achievement of treatment targets. In the absence of a cure-like pancreas or islets transplants, artificial “closed-loop” systems mimicking the pancreatic activity have been also developed. Conclusions. Individualized treatment plans for insulin initiation and administration mode are critical in achieving target glycaemic levels. Progress in these fields is expected to facilitate and improve the quality of life of diabetic patients.

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Section: Insulin Therapymentioning

confidence: 99%