Based upon the “quintuple helix” model (Carayannis et al., 2012; Carayannis & Campbell, 2010), this research analyzes whether the differences in the level of achievement of the Sustainable Development Goals (SDGs) among 64 countries worldwide can be explained by a series of 19 institutional variables related to five dimensions such as cultural orientation, economic development, the education‐labor system, the political‐legal system and innovation. Our results highlight the crucial role of public policies in attaining SDGs through the improvement of institutional quality, governance systems and economic freedom as well as with the promotion of education and the innovation ecosystem. In this regard, the adoption of the “quintuple helix” model through the interrelation of the government, Universities and the private sector is deemed relevant in order to face the social and environmental challenges posed by the SDGs.