Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial

Cate‐Hoek, Arina J. ten; Amin, Elham E.; Bouman, A.C.; Meijer, Karina; Tick, Lidwine W.; Middeldorp, Saskia; Mostard, Guy J M; Wolde, Marije ten; Heiligenberg, Simone M. van den; Wissen, Sanne van; Poel, Marlene H. van de; Villalta, Sabina; Serné, Erik H.; Otten, Hans-Martin; Klappe, E. H.; Bistervels, Ingrid M.; Piersma-Wichers, Margriet; Prandoni, Paolo; Joore, Manuela A.; Prins, Martin H.; Cate, Hugo Ten; Nijziel, M. R.; Lauw, Mandy N.; Cheung, Y. Whitney; Poel, Marlène H. W. van de; Vedovetto, Valentina

doi:10.1016/s2352-3026(17)30227-2

Cited by 76 publications

(67 citation statements)

References 43 publications

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“…The recently published IDEAL-DVT study confirmed that it may be possible to individualise ECS treatment. Patients were randomized to standard duration ECS therapy (24 months) or an individualised duration of ECS based on the Villalta score during follow-up [8]. All patients were treated with ECS class III.…”

Section: Discussionmentioning

confidence: 99%

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Elastic compression stockings one year after DVT diagnosis: Who might discontinue?

Mol

Dronkers

Ree

et al. 2019

Thrombosis Research

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License: Article 25fa pilot End User Agreement This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act (Auteurswet) with explicit consent by the author. Dutch law entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. This publication is distributed under The Association of Universities in the Netherlands (VSNU) 'Article 25fa implementation' pilot project. In this pilot research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons.

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Section: Discussionmentioning

confidence: 99%

“…In contrast, the IDEAL DVT study showed that individualised therapy with compression therapy, i.e. stopping ECS therapy after a minimal duration of 6 months in case of a Villalta score ≤ 4 on two consecutive visits, was non-inferior to continuing ECS therapy for two years [8].…”

Section: Introductionmentioning

confidence: 90%

Elastic compression stockings one year after DVT diagnosis: Who might discontinue?

Mol

Dronkers

Ree

et al. 2019

Thrombosis Research

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“…In the IDEAL DVT Study (based on the group of 865 patients with DVT), the individualization of the compression treatment duration was proposed. The shortening of the compression use to 6 month therapy in some of the investigated patients (based on the Villalta score assessment) resulted in the same clinical outcome as the continuous 2 year therapy (35).…”

Section: Compression Stocking In Pts Preventionmentioning

confidence: 80%

Post-thrombotic syndrome prevention – do we really know the predictive factors?

Urbanek

2019

Phlebologie

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Despite an increasing knowledge and experience regarding deep vein thrombosis (DVT) treatment, the rate of post-thrombotic syndrome (PTS) remains still relatively high. According to the current knowledge it is still difficult to predict on the individual basis, who of the DVT patients will develop PTS as late complication of the vein thrombosis. Among the factors influencing the higher prevalence of PTS, the ipsilateral DVT recurrence is of the highest importance. The other factors which should be mentioned are age, obesity, previous chronic venous disease as well as a proximal DVT location or lack of symptoms’ resolution in the early treatment. Looking for the most effective PTS prevention method several clinical trials were performed regarding pharmacological DVT treatment, use of early mobilization and medical compression stocking as well as an implementation of the thrombectomy and thrombolysis. This paper presents a review of the current knowledge regarding the PTS predictive factors and prevention.

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“…Whether PTS can be prevented by elastic compression stockings in patients with DVT is a matter of debate, and the American Heart Association guidelines give a weak (class IIB) recommendation against routine use of elastic compressions stockings . In our practice we prescribe initial and individualized compression therapy . Catheter‐directed thrombolysis for extensive proximal DVT does not unequivocally reduce the risk of PTS or improve QoL, while it increases bleeding risk .…”

Section: Post‐thrombotic Symptomsmentioning

confidence: 99%

Sex matters: Practice 5P's when treating young women with venous thromboembolism

Bistervels

Scheres

Middeldorp

2019

Journal of Thrombosis and Haemostasis

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Sex matters when it comes to venous thromboembolism (VTE). We defined 5P'speriod, pill, prognosis, pregnancy, and postthrombotic syndrome -that should be discussed with young women with VTE. Menstrual blood loss (Period) can be aggravated by anticoagulant therapy. This seems particularly true for direct oral anticoagulants.Abnormal uterine bleeding can be managed by hormonal therapy, tranexamic acid, or modification of treatment. The use of combined oral contraceptives (Pill) is a risk factor for VTE. The magnitude of the risk depends on progestagen types and estrogen doses used. In women using therapeutic anticoagulation, concomitant hormonal therapy does not increase the risk of recurrent VTE. Levonorgestrel-releasing intrauterine devices and low-dose progestin-only pills do not increase the risk of VTE. In young women VTE is often provoked by transient hormonal risk factors that affects prognosis. Sex is incorporated as predictor in recurrent VTE risk assessment models.However, current guidelines do not propose using these to guide treatment duration.Pregnancy increases the risk of VTE by 4-fold to 5-fold. Thrombophilia and obstetric risk factors further increase the risk of pregnancy-related VTE. In women with a history of VTE, the risk of recurrence during pregnancy or post partum appears to be influenced by risk factors present during the first VTE. In most women with a history of VTE, antepartum and postpartum thromboprophylaxis with low-molecular-weight heparin is indicated. Women generally are affected by VTE at a younger age then men, and they have to deal with long-term complications (Post-thrombotic syndrome) of deep vein thrombosis early in life. K E Y W O R D Santicoagulants, contraceptives, female, pregnancy, venous thromboembolism

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Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial

Cited by 76 publications

References 43 publications

Elastic compression stockings one year after DVT diagnosis: Who might discontinue?

Elastic compression stockings one year after DVT diagnosis: Who might discontinue?

Post-thrombotic syndrome prevention – do we really know the predictive factors?

Sex matters: Practice 5P's when treating young women with venous thromboembolism

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