Individual variation in locomotor behavior and maximal oxygen consumption in mice

Friedman, Wendy A; Garland, Theodore; Dohm, Michael R.

doi:10.1016/0031-9384(92)90438-8

Cited by 89 publications

(78 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies in our lab have also found Hsd:ICR mice to run faster on the second trial day (10,13). The behavior of the hybrid mice was intermediate to that of the wild and lab mice, as they exhibited no significant tendency to be faster on either trial day.…”

Section: Speedsupporting

confidence: 48%

“…Previous studies have documented correlations between fiber size and metabolic capacity in rats and lizards (18,37). In a previous study of 35 male Hsd:ICR mice, we reported a positive correlation between sprint speed and maximal oxygen consumption (',¢O2max) determined during forced treadmill exercise (13). In a larger study of about 300 Hsd:ICR mice, we also found no significant correlation between speed and gastrocnemius muscle mass (as noted above), and the correlation with VO2max was lower (10).…”

Section: Discussionmentioning

confidence: 67%

“…1 and RESULTS). Repeated measurement of wild and lab individuals over several days (or weeks), and in multiple types of tests [e.g., open-field or voluntary wheel-running behavior (11,13)] would allow further insight concerning the extent to which "motivation" or "fear" can account for differences in locomotor behavior; however, repeated testing could also lead to physical conditioning (e.g., 2,37), which might confound comparisons.…”

Section: Discussionmentioning

confidence: 99%

“…As compared with house mice captured in the wild (usually living commensally), lab strains typically exhibit many differences, including less responsiveness to environmental cues affecting reproduction, higher growth rates, and much more docile temperaments (6,34,38). As part of a larger research program using house mice as a model system for quantitative genetic analyses (10) of questions derived from evolutionary physiology (13,15,21) have compared a randombred strain of laboratory house mice (Hsd:ICR) with wild mice captured from a commensal Wisconsin population. In this comparison, we also found many differences, such as the lab mice being larger at all ages postweaning and displaying less voluntary activity on running wheels (11,35).…”

Section: Musmentioning

confidence: 99%

“…This lack of correlation is consistent both with theoretical expectations [Ch. 9 of (2), references in (16)] and with most empirical comparisons within and across species of mammals (16 and references therein), including our previous studies of Hsd:ICR house mice (10,11,13). For example, in a quantitative genetic study of 347 Hsd:ICR mice (10), log maximal sprint speed was not significantly correlated with log body mass (r = 0.050; 2-tailed p = 0.357).…”

Section: Speedmentioning

confidence: 99%

See 4 more Smart Citations

Maximal sprint speeds and muscle fiber composition of wild and laboratory house mice

Garland

Gleeson

Aronovitz

et al. 1995

Physiology & Behavior

Self Cite

View full text Add to dashboard Cite

GARLAND, T., JR., T. T. GLEESON, B. A. ARONOVITZ, C. S. RICHARDSON AND M. R. DOHM. Maximal sprint speeds and muscle fiber composition of wiM and laboratory house mice. PHYSIOL BEHAV 58(5) 869-876, 1995.--We compared males from four groups of house mice (Mus domesticus), all bred and raised under common conditions in the laboratory: randombred Hsd:ICR, a wild population from Wisconsin; hybrids from lab dams; hybrids from wild dams.. Wild mice were much faster sprinters (maximal forced sprint speeds over 1.0 m ranged from 2.38 to 3.34 m/s) than were lab mice (range = 0.89-1.68 m/s). Hybrids exhibited intermediate speeds (range = 1.54-2.70 m/s) and body masses, indicating largely additive inheritance. Type-specific mean muscle fiber cross-sectional areas of the gastrocnemius muscle did not differ significantly among groups. Percentage cross-sectional areas occupied by each of the three identified fiber types also did not differ significantly among groups, nor did they covary with body mass. For their body mass, however, lab mice had smaller gastrocnemius muscles than did wild and hybrid mice, which had muscles of similar size. Although we cannot rule out the possibility that smaller gastrocnemius muscles or slight differences in fiber composition account for the lower sprint speeds of the lab mice, we suggest that differences in unmeasured physiological, behavioral or motivational factors are probably the primary cause. This interpretation is supported by a lack of correlation between individual differences in sprint speed and either relative gastrocnemius muscle mass or muscle fiber type composition.

show abstract

Section: Speedsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Musmentioning

confidence: 99%

Section: Speedmentioning

confidence: 99%

See 3 more Smart Citations

Maximal sprint speeds and muscle fiber composition of wild and laboratory house mice

Garland

Gleeson

Aronovitz

et al. 1995

Physiology & Behavior

Self Cite

View full text Add to dashboard Cite

show abstract

“Personality” in laboratory mice used for biomedical research: A way of understanding variability?

Lewejohann

Zipser

Sachser

2011

Developmental Psychobiology

View full text Add to dashboard Cite

The mouse, including countless lines of transgenic and knockout mice, has become the most prominent model organism in biomedical research. Behavioral characterization is often conducted in batteries of short tests on locomotion, anxiety, learning and memory, etc. In such tests, any individual differences within groups are usually considered to be disturbing variance. In order to reduce variance in experimental animal research enormous efforts of standardization have been made. While a substantial reduction of variability has been reached compared to the earlier years of experimental animal studies a considerable amount of inter-individual differences still seems to escape standardization. This effect is demonstrated and evaluated by re-analyzing data from two experiments conducted in our laboratory with inbred mice. Interestingly, behavioral patterns of individual animals seem to be correlated across context and time. In evolutionary biology, "animal personalities" have been discussed recently to comprise such stable patterns. We argue here, that nonrandom behavioral correlations across contexts and time might underlie the variability commonly found in biomedical mouse studies.

show abstract

Individual inconsistencies in basal and summit metabolic rate highlight flexibility of metabolic performance in a wintering passerine

et al. 2015

View full text Add to dashboard Cite

Resident passerines inhabiting high latitude environments are faced with strong seasonal changes in thermal conditions and energy availability. Summit metabolic rate (maximal metabolic rate elicited by shivering during cold exposure: M(sum)) and basal metabolic rate (BMR) vary in parallel among seasons and increase in winter due to cold acclimatization, and these adjustments are thought to be critical for survival. Wintering individuals expressing consistently higher M(sum) and BMR could therefore be seen as better performers with higher chances of winter survival than those exhibiting lower metabolic performance. In this study, we calculated repeatability to evaluate temporal consistency of body mass, BMR and M(sum) within and across three consecutives winters in black-capped chickadees (Poecile atricapillus). We found that body mass was significantly repeatable both within and across winters (R 0.51-0.90). BMR (R 0.29-0.47) was only repeatable within winter while M(sum) was repeatable both among (R 0.33-0.49) and within winters (R 0.33-0.49) with the magnitude and significance of repeatability in both variables depending on the year and whether they were corrected for body mass or body size. The patterns of repeatability observed among years also differed between the two variables. Our findings suggest that the relative ranking of individuals in winter metabolic performance is affected by local ecological conditions and can change within relatively short periods of time.

show abstract

Individual variation in locomotor behavior and maximal oxygen consumption in mice

Cited by 89 publications

References 34 publications

Maximal sprint speeds and muscle fiber composition of wild and laboratory house mice

Maximal sprint speeds and muscle fiber composition of wild and laboratory house mice

“Personality” in laboratory mice used for biomedical research: A way of understanding variability?

Individual inconsistencies in basal and summit metabolic rate highlight flexibility of metabolic performance in a wintering passerine

Contact Info

Product

Resources

About