Individual Variability in Human Tibia Lead Concentration

Todd, Andrew C.; Parsons, Patrick J.; Tang, Shida; Moshier, Erin

doi:10.2307/3454861

Cited by 13 publications

(18 citation statements)

References 17 publications

(27 reference statements)

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“…On the basis of our results, we can confirm that it was the cancellous bone tissue of the hip joint that showed the largest accumulation of the minerals under study. Cancellous bone is the most metabolically active type of osseous tissue and this has been described in numerous publications [3,[15][16][17][18]. Next in order was cortical bone tissue, then cancellous bone from the intertrochanteric area.…”

Section: Resultsmentioning

confidence: 99%

Distribution of magnesium, calcium, sodium and potassium in tissues of the hip joint

Brodziak-Dopierała

Kwapuliński²,

Sobczyk³

et al. 2013

Magnesium Research

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The aim of this study was to determine the distribution of magnesium, calcium, sodium and potassium in tissues of the hip joint and to look for any correlations between these minerals.The study was performed using hip joint samples taken from people living in the Upper Silesian Industrial Region in Poland. Ninety one subjects, 66 women and 25 men, were included in this study. The samples were obtained intra-operatively during hip joint replacement procedures. The concentrations of magnesium, calcium, sodium and potassium were measured by atomic absorption spectrophotometry (AAS). Our results showed that these minerals are most abundant in the cancellous bone of the hip joint. They were found next more abundantly in the cortical bone and the cancellous bone from the intertrochanteric area. Levels of magnesium, potassium and calcium were lower in articular cartilage compared with other parts of the hip joint; however, sodium levels were at their highest in this tissue. The lowest levels of these minerals were found in the articular capsule. Those patients with fractures of the femoral neck had lower levels of magnesium, potassium, and calcium, but higher levels of sodium compared with the group with degenerative changes. We can also confirm that in the population studied, calcium levels in cancellous bone of the head of the femur decreased with age.

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Section: Resultsmentioning

confidence: 99%

Distribution of magnesium, calcium, sodium and potassium in tissues of the hip joint

Brodziak-Dopierała

Kwapuliński²,

Sobczyk³

et al. 2013

Magnesium Research

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“…Todd et al 64 reported contiguous inhomogeneities in the distribution of Pb toward the proximal and distal ends of the tibia bones. They speculated that the region of lower Pb concentration has lower blood flow in the Haversian canals and, consequently, less Pb available for uptake into bone matrix during bone remodeling (Todd et al 64 ). Trabecular bone has a larger surface area and a greater volume of blood delivered per unit time, compared to cortical bone.…”

Section: Bone Leadmentioning

confidence: 99%

A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations and future needs

Barbosa

Tanus‐Santos

Gerlach

et al. 2006

Ciênc. saúde coletiva

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Lead concentration in whole blood (Blood-Pb) is the primary biomarker used to monitor exposure to this metallic element. However, the difficulty in assessing the exact nature of Pb exposure is dependent not so much on problems with current analytical methodologies, but rather on the complex toxicokinetics of Pb within various body compartments. If we are to differentiate more effectively between Pb that is stored in the body for years and Pb from recent exposure, information on other biomarkers of exposure may be needed. None of the current biomarkers of internal Pb dose has yet been accepted by the scientific community as a reliable substitute for a Blood-Pb measurement. This review focuses on the limitations of biomarkers of Pb exposure, and the need to improve the accuracy of their measurement. We present here only the traditional analytical protocols in current use and we attempt to assess the influence of confounding variables on Blood-Pb levels. Finally, we discuss the interpretation of Blood-Pb data with respect to both external and endogenous Pb exposure, past or recent exposure, as well as the significance of lead determinations in human specimens including hair, nails, saliva, bone, blood, urine, feces, and exfoliated teeth.

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“…Several techniques were employed to analyse bones: an overview can be found in Table 1. mineral structure and organic content infrared spectroscopy [30][31][32][33][34] X-ray diffraction [7,[31][32][33]35] thermogravimetry [7,36,37] quantitative elemental analysis atomic spectroscopy techniques [7,28,29,[38][39][40][41][42][43][44][45][46][47][48] particle induced X-ray and gamma-ray emission [17,32,[49][50][51][52] X-ray fluorescence [4,9,15,35,53] neutron activation analysis [7,8,54,55] inductively coupled mass spectrometry [1,7,18,28,42,…”

Section: Introductionmentioning

confidence: 99%

On the use of trace elements in ancient necropolis studies: Overview and ICP-MS application to the case study of Valdaro site, Italy

Corti¹,

Rampazzi²,

Ravedoni³

et al. 2013

Microchemical Journal

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The cross-cutting study of archaeological human remains is an important tool for improving the knowledge of the past civilities. Bones are actually bio-archives, storing information about the lifestyles of the individuals, the place where they lived, the migration habits. In particular, some peculiar trace elements (such as strontium and zinc) are considered indicators of the so-called paleodiet, i.e. whether characterized by vegetables, cereals or meat. A complete overview of the concerning literature is the starting point of this work. A straightforward optimized methodology for the study of ancient bones is proposed coupling for the first time trace element determination by ICP-MS (Mg, Mn, Cu, Zn, Sr and Pb were investigated) and statistical data analysis. The protocol was applied to samples coming from a necropolis (dated from Neolithic to Bronze Age) found in Northern Italy including 'The Valdaro Lovers', a rare double burial where the two skeletons were facing each other with their arms wrapped around in an enduring embrace. Principal Component Analysis and Discriminant Analysis permitted to correctly classify individuals by the historical period in which they lived according to the archaeological and anthropological information. The results were compared with those found in the literature and a critical discussion on the use of trace metals in this case study is given.

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Individual Variability in Human Tibia Lead Concentration

Cited by 13 publications

References 17 publications

Distribution of magnesium, calcium, sodium and potassium in tissues of the hip joint

Distribution of magnesium, calcium, sodium and potassium in tissues of the hip joint

A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations and future needs

On the use of trace elements in ancient necropolis studies: Overview and ICP-MS application to the case study of Valdaro site, Italy

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