Individual Variability in Functional Connectivity Architecture of the Human Brain

Mueller, Sophia; Wang, Danhong; Fox, Michael; Yeo, B.T. Thomas; Sepulcre, Jorge; Sabuncu, Mert R.; Shafee, Rebecca; Lu, Jie; Liu, Hesheng

doi:10.1016/j.neuron.2012.12.028

Cited by 980 publications

(1,067 citation statements)

References 60 publications

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“…Developmental selection in these gaps fosters the emergence of "noncanonical" association networks primarily interconnected with each other rather than with more developmentally constrained peripheral sensorimotor systems. As expected, these relatively unconstrained association cortices are also relatively late developing (59,63) and variable in connectivity across individuals (64). Indeed, comparative evidence indicates human-specific changes in the rate and timing of synaptogenesis, synapse elimination, and cortical myelination, resulting in increased plasticity into adulthood (65,66).…”

Section: An Extended Evolutionary Frameworkmentioning

confidence: 57%

Evolutionary neuroscience of cumulative culture

Stout

Hecht

2017

Proc. Natl. Acad. Sci. U.S.A.

126

152

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Culture suffuses all aspects of human life. It shapes our minds and bodies and has provided a cumulative inheritance of knowledge, skills, institutions, and artifacts that allows us to truly stand on the shoulders of giants. No other species approaches the extent, diversity, and complexity of human culture, but we remain unsure how this came to be. The very uniqueness of human culture is both a puzzle and a problem. It is puzzling as to why more species have not adopted this manifestly beneficial strategy and problematic because the comparative methods of evolutionary biology are ill suited to explain unique events. Here, we develop a more particularistic and mechanistic evolutionary neuroscience approach to cumulative culture, taking into account experimental, developmental, comparative, and archaeological evidence. This approach reconciles currently competing accounts of the origins of human culture and develops the concept of a uniquely human technological niche rooted in a shared primate heritage of visuomotor coordination and dexterous manipulation.brain evolution | cultural evolution | archaeology | imitation

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Section: An Extended Evolutionary Frameworkmentioning

confidence: 57%

Evolutionary neuroscience of cumulative culture

Stout

Hecht

2017

Proc. Natl. Acad. Sci. U.S.A.

126

152

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“…Stimulation of different functional regions can lead to differences in propagation pathways, depending on individual functional connectivity. Finally, functional brain connectivity shows substantial variability between participants, with strong variability observed in the prefrontal cortex (Mueller et al, 2013). Moreover, resting state functional connectivity studies show that brain functional connectivity shows substantial temporal variability, especially in the sgACC (among other regions) (Allen et al, 2014; Handwerker, Roopchansingh, Gonzalez‐Castillo, & Bandettini, 2012; Mueller et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Finally, functional brain connectivity shows substantial variability between participants, with strong variability observed in the prefrontal cortex (Mueller et al, 2013). Moreover, resting state functional connectivity studies show that brain functional connectivity shows substantial temporal variability, especially in the sgACC (among other regions) (Allen et al, 2014; Handwerker, Roopchansingh, Gonzalez‐Castillo, & Bandettini, 2012; Mueller et al, 2013). To summarize, the structural and functional organization of the brain together with the dynamic nature of functional connectivity could explain the variability in propagation patterns of TMS‐induced activity.…”

Section: Discussionmentioning

confidence: 99%

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Vink

Mandija

Petrov

et al. 2018

Human Brain Mapping

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Major depressive disorder (MDD) is a severe mental disorder associated with high morbidity and mortality rates, which remains difficult to treat, as both resistance and recurrence rates are high. Repetitive transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) provides a safe and effective treatment for selected patients with treatment‐resistant MDD. Little is known about the mechanisms of action of TMS provided to the left DLPFC in MDD and we can currently not predict who will respond to this type of treatment, precluding effective patient selection. In order to shed some light on the mechanism of action, we applied single pulse TMS to the left DLPFC in 10 healthy participants using a unique TMS‐fMRI set‐up, in which we could record the direct effects of TMS. Stimulation of the DLPFC triggered activity in a number of connected brain regions, including the subgenual anterior cingulate cortex (sgACC) in four out of nine participants. The sgACC is of particular interest, because normalization of activity in this region has been associated with relief of depressive symptoms in MDD patients. This is the first direct evidence that TMS pulses delivered to the DLPFC can propagate to the sgACC. The propagation of TMS‐induced activity from the DLPFC to sgACC may be an accurate biomarker for rTMS efficacy. Further research is required to determine whether this method can contribute to the selection of patients with treatment resistant MDD who will respond to rTMS treatment.

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“…Sulcal variation shows a close correspondence with primary sensory and motor cytoarchitectonic areas (25) but a more variable correspondence with high-order association areas in both chimpanzees and humans (25,26). In humans, sulcal morphology shows a high degree of interindividual variability that is linked to differences in functional networks and longrange corticocortical connectivity (27), whereas lobe-or regionspecific volumetric measures and cortical thickness have been shown to be less variable and highly heritable (28).…”

Section: Significancementioning

confidence: 99%

Relaxed genetic control of cortical organization in human brains compared with chimpanzees

Gómez‐Robles

Hopkins

Schapiro

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

154

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The study of hominin brain evolution has focused largely on the neocortical expansion and reorganization undergone by humans as inferred from the endocranial fossil record. Comparisons of modern human brains with those of chimpanzees provide an additional line of evidence to define key neural traits that have emerged in human evolution and that underlie our unique behavioral specializations. In an attempt to identify fundamental developmental differences, we have estimated the genetic bases of brain size and cortical organization in chimpanzees and humans by studying phenotypic similarities between individuals with known kinship relationships. We show that, although heritability for brain size and cortical organization is high in chimpanzees, cerebral cortical anatomy is substantially less genetically heritable than brain size in humans, indicating greater plasticity and increased environmental influence on neurodevelopment in our species. This relaxed genetic control on cortical organization is especially marked in association areas and likely is related to underlying microstructural changes in neural circuitry. A major result of increased plasticity is that the development of neural circuits that underlie behavior is shaped by the environmental, social, and cultural context more intensively in humans than in other primate species, thus providing an anatomical basis for behavioral and cognitive evolution. brain evolution | plasticity | hominins | neocortex | altriciality C ompared with nonhuman primates, human brains are significantly enlarged, reorganized, and have a disproportionately expanded neocortex (1-3). The fossil evidence demonstrates that these changes occurred in the hominin lineage over the last ∼6-8 My (4-9) in parallel with modifications to neurodevelopmental rates (10-13). Although some of these changes have been linked to certain genetic variants in the human lineage [either shared with other late hominin species or exclusive to modern humans (14, 15)], exploring brain evolution in hominins is challenging because of the limitations of the endocranial fossil record (4, 5). Comparisons of chimpanzee and human brains therefore are essential to reveal the neural traits that differ between the two species, that underlie their behavioral specializations, and that must have evolved after they split from their last common ancestor.Human behavioral and cognitive development is highly dependent on cultural influences and social learning (16,17). Notably, modern human behavioral adaptations for living in diverse habitats depend on skills and information learned from others (18). Similarly, it has been demonstrated that enculturated great apes perform better in different tasks related to physical and, especially, social cognition (19), underscoring the importance of environmental influences in shaping behavior. These observations are congruent with experimental studies in mouse models showing that variation in sensory experience early in postnatal life causes reorganization of neural circuits that underlie...

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Individual Variability in Functional Connectivity Architecture of the Human Brain

Cited by 980 publications

References 60 publications

Evolutionary neuroscience of cumulative culture

Evolutionary neuroscience of cumulative culture

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Relaxed genetic control of cortical organization in human brains compared with chimpanzees

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