Individual Specificity of Dog Serum and Plasma

Freeman, Norman E.; Schecter, A. E.

doi:10.1126/science.96.2480.39-a

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1955

2002

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“…Homologous plasma, free of cells and isoagglutinins, is usually considered as innocuous to an animal as its own plasma, but in the dog intradermal testing has shown plasma to be individually specific. 4 ' 5 Intradermal injection of plasma from another dog produces a well marked wheal within a few minutes, while similar injection of the dog's own plasma produces no such response. Whealing occurs on the initial trial; sensitization in the usual sense is therefore not a factor.…”

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confidence: 99%

Transfusion Reactions due to Plasma Incompatibility in Dogs

Bliss

Johns

Burgen

1959

Circulation Research

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Plasma incompatibility was investigated as a possible factor in transfusion reactions in dogs. Urticaria, failure to retain within the circulation the equivalent of transfused plasma volume and protein, and increased gastric acid secretion almost invariably followed transfusion of plasma from another dog but not transfusion of the dog's own plasma. The cutaneous reactions were abolished and the retention of plasma was improved by administration of an antihistamine. Erythroeyte isoagglutinins did not appear to be involved in these reactions. 79

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