Individual risks to adolescent health, caused by contaminating the air, and their relationship with the levels of specific autoantibodies

Abstract

The high levels of the air pollution create prerequisites for the development of the pathology of target organs exposed to chemical agents. Big enterprises of oil refining and chemical industry of the Irkutsk region are located in the cities of Angarsk and Sayansk. The average level of the air pollution for several years in these cities is assessed as high and moderate, respectively. The use of the personalized approach may allow to more correctly evaluate the risk for the damage to health and the body’s response to external impacts. The purpose of this study was to assess the risk offormation ofpathological processes in the body of adolescents in the conditions of inhalation exposure to chemicals, taking into account the individual load and study of the level of specific autoantibodies. The study included 373 adolescents from the city with high levels of air pollution and 188 schoolchildren from the city with a moderate level pollution. There was made an evaluation of the individual chemical hazard load on adolescents ’ body due to the air pollution, physiologicalfeatures and the organization of educational process and leisure. There were studied the levels of specific autoantibodies, reflecting the state of the organs - targets for the impact ofpollutants. The calculation of the individual chemical load allows to calculate indices of the hazard for the health problems of each individual and to identify individuals at increased risk of developing diseases of organs and systems, which are targets for exposure to pollutants. The increase in the hazard index of developing respiratory diseases was found to be accompanied by an increase of the relative content of autoantibodies against membrane antigens of the lung tissue. There was revealed the elevation in autoantibodies levels to the proteins of vascular endothelial with increasing hazard index of disturbances in the cardiovascular system in adolescents living in city with high levels of air pollution.

Public Health Risk Assessment Due to Air Pollution in the Temir District of the Aktobe Region

“…These objects, often surrounded by various settlements, pose a direct threat to the health of the surrounding population. In this connection, one should conduct an assessment of health risks from pollutant emissions associated with the future operation of an industrial facility, even before commissioning [14], [15].…”

Parameterization of relationships between risk factors and public health under chronic exposure to complex ambient air pollution

“…Простота реализации такого подхода и легкость получения необходимой информации для проведения расчетов выделяет этот метод как наиболее доступный для проведения экспресс-оценок загрязнения объектов среды обитания и выбора приоритетных факторов риска. Подход широко используется при оценке неблагоприятного воздействия загрязненного атмосферного воздуха на здоровье жителей различных населенных мест [5,6], оценке риска воздействия загрязняющих веществ на здоровье различных групп населения [7][8][9], при решении задач влияния предприятий на состояние объектов среды обитания [10], при проведении мониторинговых исследований загрязнения атмосферного воздуха, воды, почвы и пр. [11][12][13], для решения задач градостроительства и организации природоохранной деятельности, а так-же для задач оценки эффективности мероприятий по обеспечению санитарно-эпидемиологического благополучия населения.…”

Parameterization of relationships between risk factors and public health under chronic exposure to complex ambient air pollution

“…This makes the method the most available for conducing express-estimations of pollution levels in environmental objects and selecting priority risk factors. The approach is widely used in assessing adverse effects produced by ambient air pollution on health of people in settlements [5,6]; in assessing health risks created by exposure to pollutants for different population groups [7][8][9]; in estimating and mitigating influence exerted by an enterprise on environmental objects [10]; in conducting monitoring studies with their focus on pollution in ambient air, water, soils, etc. [11][12][13]; in urban development and organization of environmental protection; as well as in estimating effectiveness of activities aimed at providing sanitary-epidemiological wellbeing of the population.…”