Objective: This study aimed to investigate the effect of hearing protection devices (HPDs) on speech intelligibility in Persian work environments. Three current earmuffs and three earplugs and one of the prototypes of molded earplug were tested on 15 male subjects which were randomly selected. The noise reduction of HPDs was measured based on the Real Ear Attenuation at Threshold (REAT) method. Speech intelligibility during using HPDs was determined based on the speech discrimination score (SDS) at two signal to noise (S/N) ratios (0 and +5). Data were analyzed using SPSS, version 22.Results: The actual to nominal noise reduction rating values were from 47% to 84% for HPDs. The earmuffs showed higher ratios of actual to nominal noise reduction compared with the earplugs. At two S/N ratios, no significant differences were observed in speech intelligibility using HPDs (p >0.05). However, at S/N ratio=0, the speech intelligibility descriptively has been improved by using common earmuffs up to 9.07 %. There was a significant difference up to 21.27% in speech intelligibility for proposed molded earplugs at S/N ratio=0(p <0.05). It is concluded that, if the trend of signal to noise ratio is positive, the HPDs will reduce the ability to understand speech.