Individual differences in the forced swimming test and the effect of environmental enrichment: Searching for an interaction

Sequeira‐Cordero, Andrey; Mora-Gallegos, Andrea; Cuenca-Berger, Patricia; Trías, Jaime Fornaguera

doi:10.1016/j.neuroscience.2014.01.047

Cited by 10 publications

(9 citation statements)

References 60 publications

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“…The recent human findings described above are consistent with findings in rodent models of stress where serotonin and CRH levels in the nucleus accumbens have been related to individual differences in depression-like behavior [11], and blockade of the kappa opioid receptor in the same brain region prevented depression-like behavior [12]. The prefrontal cortex also plays a role in individual differences in response to stressors [13].…”

Section: Behavioral and Neurobiological Parallels Between Temperamentsupporting

confidence: 78%

Utilizing a unique animal model to better understand human temperament

Turner¹,

Flagel

Blandino³

et al. 2017

Current Opinion in Behavioral Sciences

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Individual differences in temperament are associated with psychopathology in humans. Moreover, the relationship between temperament and anxiety-, depression-, PTSD- and addiction-related behaviors can be modeled in animals. This review will highlight these relationships with a focus on individual differences in the response to stressors, fear conditioning and drugs of abuse using animals that differ in their response to a novel environment. We will discuss behavioral and neurobiological commonalities amongst these behaviors with a focus on the hippocampus and, in particular, growth factors as promising novel targets for therapeutic intervention.

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Section: Behavioral and Neurobiological Parallels Between Temperamentsupporting

confidence: 78%

Utilizing a unique animal model to better understand human temperament

Turner¹,

Flagel

Blandino³

et al. 2017

Current Opinion in Behavioral Sciences

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“…Other studies have failed to identify differences in locomotion parameters between low and high immobility rats [14,49,58]. Methodological issues may be involved in these conflicting findings because we performed the locomotion evaluation 24 h after the last swimming session, whereas other authors have conducted the tests before [58], three days after [14] and one week after the session [57]. In addition, we demonstrated that the overall time spent exploring both objects during the training phase was not affected by the FST.…”

Section: Discussionmentioning

confidence: 68%

“…We identified a significant positive correlation between immobility acquisition and the number of crossings, i.e., the rats that displayed the highest immobility acquisition exhibited more crossings during spontaneous locomotion evaluation. This finding was unexpected because a negative correlation between the immobility duration and the number of crossings and rearings was identified [57]. Other studies have failed to identify differences in locomotion parameters between low and high immobility rats [14,49,58].…”

Section: Discussionmentioning

confidence: 93%

Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments

Borsoi

Antonio

Viana

et al. 2015

Physiology & Behavior

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“…El papel del sistema CRF-CRFR1 no solamente es importante en relación con las diferencias individuales sino que además, podría tener al mismo tiempo una función mediadora de los efectos del enriquecimiento ambiental (Sequeira-Cordero et al, 2014b). El ambiente es capaz de modificar la expresión de los genes y esta interacción genes-ambiente es la que determina la mayoría (sino todos) de los rasgos fenotípicos de los individuos (Zhang & Meaney, 2010).…”

Section: Diferencias Individuales En Conductas Relacionadas Con La Deunclassified

“…En este contexto, nuestro grupo estudió también el efecto del enriquecimiento ambiental en animales con baja y alta inmovilidad en la PNF con el objetivo de buscar una interacción entre las diferencias individuales y la respuesta al alojamiento, lo cual evidenciaría una interacción que biológicamente, se traduce como la presencia de factores que no sólo son importantes como moduladores de la conducta (alta o baja inmovilidad), sino también como mediadores del efecto ambiental. Nuestros resultados mostraron que animales con baja inmovilidad enriquecidos tienen menores niveles de CRF en el núcleo accumbens si se comparan con animales alojados en condiciones estándar (i.e., alojados en grupos de cuatro y sin acceso a los estímulos propios de la caja de enriquecimiento), mientras que animales con alta inmovilidad enriquecidos presentaron una tendencia marginalmente significativa al incremento de CRFR1 en el núcleo accumbens comparados con sus contrapartes en condiciones estándar (Sequeira-Cordero et al, 2014b).…”

Section: Diferencias Individuales En Conductas Relacionadas Con La Deunclassified

Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

Cordero

Trías

2014

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Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresiónResumen. El estudio de las diferencias individuales en la prueba de nado forzado (PNF) en ratas permite la identificación de factores de susceptibilidad o de resistencia en el desarrollo conductas relacionadas con la depresión. Para estudiar estas diferencias, varios grupos de ratas fueron sometidos a la PNF; posteriormente, los animales con baja y alta inmovilidad fueron comparados, lo que permitió identificar una serie de características que podrían estar actuando como factores de riesgo o de protección. Así, factores neurobiológicos como la expresión diferencial en el núcleo accumbens del receptor 1 para el factor liberador de corticotropina (CRFR1), una tasa diferencial de recambio de dopamina en esa misma región y la cinética de expresión diferencial del factor neurotrófico derivado del cerebro (BDNF) en la corteza prefrontal, podrían jugar un papel importante en la modulación de conductas depresivas. La presente revisión resume nuestros resultados más importantes en esta línea de investigación.Palabras clave. Diferencias individuales, prueba de nado forzado, conducta, expresión génica, cerebro.Abstract. The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression-related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line.Keywords. Individual differences, forced swimming test, behavior, gene expression, brain.Actualidades en Psicología, 28(117), 2014, 53-66 ISSN 2215 Individual differences in animal models: an approach to study neurobiological factors related to depression

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Individual differences in the forced swimming test and the effect of environmental enrichment: Searching for an interaction

Cited by 10 publications

References 60 publications

Utilizing a unique animal model to better understand human temperament

Utilizing a unique animal model to better understand human temperament

Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments

Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

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