PLoS ONE volume 9, issue 6, Pe98296 2014 DOI: 10.1371/journal.pone.0098296 View full text Has correction 2014-07-21Has correction 2014-07-25
Karina Possa Abrahao, Francine Oliveira Goeldner, Maria Lucia Oliveira Souza-Formigoni

Abstract: In mice there are clear individual differences in the development of behavioral sensitization to ethanol, a progressive potentiation of its psychomotor stimulant effect. Variability in the behavioral responses to ethanol has been associated with alcohol preference. Here we investigated if the functional hyperresponsiveness of D1 receptors observed in ethanol sensitized mice leads to an increased activation of DARPP-32, a central regulatory protein in medium spiny neurons, in the nucleus accumbens - a brain reg…

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