Individual differences in chemotherapy-induced anticipatory nausea

Rodríguez, Ma Paloma González

doi:10.3389/fpsyg.2013.00502

Cited by 10 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Associative learning is the ability to acquire a link between two or more stimuli, such that the presentation of one stimulus can activate or inhibit the expectation of another. Associative learning is thought to underlie a range of memory and learning capacities, including Pavlovian and instrumental conditioning (Bouton, 1994; Colwill & Rescorla, 1986; Wasserman & Miller, 1997), as well as more general aspects of human performance, such as instrumental or agentic control (Byrom, Msetfi, & Murphy, 2015; Msetfi, Murphy, Simpson, & Kornbrot, 2005), spatial navigation (Buckley, Smith, & Haselgrove, 2015; Pearce, 2009), motivational systems (e.g., appetite; Brunstrom, 2007), as well as response systems related to pathology, such as fear responses to threat (Arnaudova et al, 2013; Duits et al, 2015; Lissek et al, 2009), chemotherapy-induced anticipatory nausea (Hall, Stockhorst, Enck, & Klosterhalfen, 2016; Rodríguez, 2013), and the development and maintenance of substance addiction (Everitt & Robbins, 2016; Hogarth, Balleine, Corbit, & Killcross, 2013; Hogarth & Chase, 2012; Torres et al, 2013). Across all of these phenomena, experimental work suggests that individuals differ in their associative learning (e.g., Murphy & Msetfi, 2014).…”

mentioning

confidence: 99%

Individual difference in configural associative learning.

Byrom¹,

Murphy

2016

Journal of Experimental Psychology: Animal Learning and Cogniti

View full text Add to dashboard Cite

Individuals differ in their ability to acquire associations between stimuli and paired outcomes, an ability that has been proposed to be independent of general metrics of intelligence or memory (e.g., Kaufman, DeYoung, Gray, Brown, & Mackintosh, 2009). The nature of these differences may reflect the type of associative structures acquired during learning, for instance configuring stimuli to facilitate flexible learning and memory. We test the hypothesis that individuals differ in configural associative learning as distinct from simpler (elemental) stimulusoutcome learning. In Experiment 1 participants were screened for attentional scope and we found that attentional scope predicted configural associative learning that could not be explained simply in terms of differences in strength of associative learning. In Experiment 2, attentional scope was trained resulting in a shift in participants' ability to learn about subsequent configurations unrelated to the training material. We discuss how the differences between individual learners reflect differences in configuring rather than simply differences in strength or speed of learning.3

show abstract

mentioning

confidence: 99%

Individual difference in configural associative learning.

Byrom¹,

Murphy

2016

Journal of Experimental Psychology: Animal Learning and Cogniti

View full text Add to dashboard Cite

show abstract

“…Anticipatory nausea (hereafter, AN) is the most common and distressing side effect of chemotherapy treatment. 1 , 2 , 3 , 4 AN causes a significant reduction in patients' quality of life and it is the main reason for the discontinuation of the treatment. 5 The development of AN is thought to result from classical conditioning.…”

Section: Introductionmentioning

confidence: 99%

Genetic and environmental influences on one‐trial conditioned context aversion in mice

İlhan

Urcelay

Kışlal

2023

Genes Brain and Behavior

View full text Add to dashboard Cite

Anticipatory nausea (AN) is caused by an association between contextual cues and the experience of nausea (the side effects of chemotherapy or radiation treatment) and it develops predominantly in female patients undergoing chemotherapy. Preclinical studies in rodents show that the administration of an illness‐inducing agent in the presence of novel contextual cues can cause conditioned context aversion (CCA) and this has been proposed to model AN. The literature also suggests that brief pre‐exposure to a novel context prior to shock delivery is critical in the development of contextual fear conditioning in rodents (a phenomenon known as Immediate Shock Deficit), but this has not been assessed in CCA. The aim of present study was to develop a CCA paradigm to assess this in outbred (CD1) and inbred (C57BL/6J) mice and evaluate potential sex differences. The results revealed that a single conditioning trial in which a distinctive context was paired with LiCl‐induced illness was sufficient to elicit a conditioned response in both female and male CD1 outbred mice, but not in C57BL/6J inbred mice. In addition, CCA was facilitated when animals had prior experience with the context. Finally, outbred female mice showed longer and more robust retention of CCA than male mice, which parallels clinical findings. The results indicate the importance of using CD1 outbred mice as an animal model of AN as well as examining sex differences in the CCA paradigm. Similar findings in humans encourage the future use of this novel CCA preclinical mouse model.

show abstract

“…After repeated chemotherapy cycles for cancer, some patients developed unpleasant side effects like strong nausea. In those cases, patients develop anticipatory nausea responses before the chemotherapy drug administration ( Symonds and Hall 2012 ; Rodríguez 2013 ). This phenomenon suggests that the administration of toxic drugs is associated with environmental cues.…”

mentioning

confidence: 99%

Maintenance of conditioned place avoidance induced by gastric malaise requires NMDA activity within the ventral hippocampus

2021

View full text Add to dashboard Cite

It has been reported that during chemotherapy treatment, some patients can experience nausea before pharmacological administration, suggesting that contextual stimuli are associated with the nauseating effects. There are attempts to reproduce with animal models the conditions under which this phenomenon is observed to provide a useful paradigm for studying contextual aversion learning and the brain structures involved. This manuscript assessed the hippocampus involvement in acquiring and maintaining long-term conditioned place avoidance (CPA) induced by a gastric malaise-inducing agent, LiCl. Our results demonstrate that a reliable induction of CPA is possible after one acquisition trial. However, CPA establishment requires a 20-min confinement in the compartment associated with LiCl administration. Interestingly, both hippocampal regions seem to be necessary for CPA establishment; nonetheless, inactivation of the ventral hippocampus results in a reversion of avoidance and turns it into preference. Moreover, we demonstrate that activation of dorsal/ventral hippocampal NMDA receptors after CS–US association is required for long-term CPA memory maintenance.

show abstract

Individual differences in chemotherapy-induced anticipatory nausea

Cited by 10 publications

References 50 publications

Individual difference in configural associative learning.

Individual difference in configural associative learning.

Genetic and environmental influences on one‐trial conditioned context aversion in mice

Maintenance of conditioned place avoidance induced by gastric malaise requires NMDA activity within the ventral hippocampus

Contact Info

Product

Resources

About