Individual differences in cardiovascular response to social challenge

Sgoifo, Andrea; Costoli, Tania; Meerlo, Peter; Buwalda, Bauke; Pico-Alfonso, Maria A.; Boer, Sietse de; Musso, Ezio; Koolhaas, Jaap M.

doi:10.1016/j.neubiorev.2004.07.001

Cited by 58 publications

(32 citation statements)

References 43 publications

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“…Correlations have been found between increases in blood pressure and plasma catecholamines following sympathetic activation [24]. The relationship between aggression and cardiovascular responsivity under social stress conditions may represent a strategy of coping with social challenge [30]. In the present work, social stress increased blood pressure and corticosterone levels, indicating an increase in sympathetic activity and further confirming that the procedure was stressful for the socially stressed rats.…”

Section: Discussionsupporting

confidence: 82%

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Ahnaou

Drinkenburg²

2016

Neuropsychobiology

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Depression is a heterogeneous disorder characterized by alterations at psychological, behavioural, physiological, neurophysiological, and neurochemical levels. Social stress is a prevalent stress in man, and the repeated social defeat stress model in rats has been proposed as being the rodent equivalent to loss of control, which in subordinate animals produces alterations that resemble several of the cardinal symptoms found in depressed patients. Here, rats followed a resident-intruder protocol for 4 consecutive days during which behavioural, physiological, and electroencephalographic (EEG) parameters were simultaneously monitored in subordinate rats. On day 5, prefrontal dopamine (DA) and hippocampal serotonin (5-HT) as well as corticosterone were measured in submissive rats that had visual, acoustic, and olfactory (but no physical) contact with a dominant, resident conspecific rat. Socially defeated rats demonstrated increases in ultrasonic vocalizations (20-25 KHz), freezing, submissive defensive behaviour, inactivity, and haemodynamic response, while decreases were found in repetitive grooming behaviour and body weight. Additionally, alterations in the sleep-wake architecture were associated with reduced active waking, enhanced light sleep, and increased frequency of transitions from light sleep to quiet wakefulness, indicating sleep instability. Moreover, the attenuation of EEG power over the frequency range of 4.2-30 Hz, associated with a sharp transient increase in delta oscillations, appeared to reflect increased brain activity and metabolism in subordinate animals. These EEG changes were synchronous with a marked increase in body temperature and a decrease in locomotor activity. Furthermore, psychosocial stress consistently increased 5-HT, DA, and corticosterone levels.The increased levels of cortical DA and hippocampal 5-HT during social threat may reflect a coping mechanism to promote alertness and psychological adaptation to provocative and threatening stimuli. These neurophysiological changes are hypothesized to be the consequence of dynamics in monoamine systems, which could be useful markers for disease progression in the aetiology of depression.

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Section: Discussionsupporting

confidence: 82%

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Ahnaou

Drinkenburg²

2016

Neuropsychobiology

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“…The same relationship between coping style and sympathetic reactivity can be observed in a comparison between strains. On average, the aggressive wild-type rats responded to social defeat with larger sympathetic (plasma noradrenaline levels) reactivity and concomitantly lower parasympathetic reactivity (as measured by increased heart rate response and decreased heart rate variability) than the less aggressive Wistar rats [Sgoifo et al, 2005]. One might conclude that proactive coping is characterized by a high sympathetic reactivity.…”

Section: Neuroendocrinology Of Coping Stylesmentioning

confidence: 94%

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

et al. 2007

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Ecological studies on feral populations of mice, fish and birds elucidate the functional significance of phenotypes that differ individually in their behavioral and neuroendocrine response to environmental challenge. Within a species, the capacity to cope with environmental challenges largely determines individual survival in the natural habitat. Recent studies indicate that individual variation within a species may buffer the species for strong fluctuations in the natural habitat. A conceptual framework will be presented that is based on the view that individual variation in aggressive behavior can be considered more generally as a variation in actively coping with environmental challenges. Highly aggressive individuals adopt a proactive coping style whereas low levels of aggression indicate a more passive or reactive style of coping. Coping styles have now been identified in a range of species and can be considered as trait characteristics that are stable over time and across situations. The dimension of coping style seems to be independent of an emotionality dimension. Hence, in the analysis of the proximate mechanisms of stress and adaptation, one has to consider the possibility that the mechanisms which determine the type of stress response might be independent from those underlying the magnitude of the response. The two coping styles differ in a number of important neurobiological and neuroendocrine systems. For example, proactive males differ significantly from reactive males in the homeostatic control of serotonergic activity resulting in completely opposite dose response relationships of various serotonergic drugs. The results so far show that proactive coping is characterized by a strong inhibitory control of the 5-HT neuron via its somatodendritic 5-HT_1A autoreceptor. It is hypothesized that the regulation of serotonin release is causally related to coping style rather than emotionality. Understanding the functional individual variation as it occurs in nature and the underlying neurobiology and neuroendocrinology is fundamental in understanding individual vulnerability to stress related disease.

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“…Hostile/aggressive Type A individuals show a positive correlation between trait aggression and emotionality measures [17,18]. Similarly, resident rats that readily attack male conspecifics have higher sympatho-adrenomedullary activation [19][20][21]. Similarly, in Physiology & Behavior 95 (2008) [591][592][593][594][595][596][597][598] pigs, aggression levels and sympathetic activation during social confrontation are positively correlated [22].…”

Section: Introductionmentioning

confidence: 99%

Is hyper-aggressiveness associated with physiological hypoarousal? A comparative study on mouse lines selected for high and low aggressiveness

Caramaschi¹,

Boer²,

Koolhaas³

2008

Physiology & Behavior

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Individual differences in cardiovascular response to social challenge

Cited by 58 publications

References 43 publications

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

Is hyper-aggressiveness associated with physiological hypoarousal? A comparative study on mouse lines selected for high and low aggressiveness

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