Individual differences in amphetamine sensitization: Dose-dependent effects

Hooks, M.S.; Jones, G. H.; Neill, Darryl B.; Justice, Joseph B.

doi:10.1016/0091-3057(92)90083-r

Cited by 130 publications

(72 citation statements)

References 23 publications

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“…We observed a negative correlation between locomotor response to saline injection and initial locomotor response to AMPH, in contrast to earlier reports of a positive correlation between heightened locomotor response to novelty and increased locomotor response to AMPH and cocaine in some (Piazza et al, 1989;Hooks et al, 1991Hooks et al, , 1992 but not all (Djano and Martin-Iverson, 2000) studies. Differences in experimental details (eg measurement of response to novelty vs our measure, response to saline injection in a novel environment) might account for the differing observations.…”

Section: Comparison With Previous Findingscontrasting

confidence: 99%

“…A relation between locomotor response to novelty and subsequent locomotor response to AMPH and cocaine has previously been described by several (Piazza et al, 1989;Hooks et al, 1991Hooks et al, , 1992, but not all investigators (Djano and Martin-Iverson, 2000). Because locomotor response to novelty might potentially influence locomotor response to saline injection, one of the measures contributing to our defined PD 128907 locomotor inhibition, the correlation between AMPH-stimulated locomotion, and responses to PD 128907 and saline (Table 3, days 12-14) were also evaluated individually.…”

Section: Behavioral Response To Amphetamine and To D3 Receptor Agonismentioning

confidence: 98%

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Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Richtand

Welge

Levant

et al. 2003

Neuropsychopharmacol

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Behavioral sensitization, the progressive and enduring enhancement of certain behaviors following repetitive drug use, is mediated in part by dopaminergic pathways. Increased locomotor response to drug treatment, a sensitizable behavior, is modulated by an opposing balance of dopamine receptor subtypes, with D1/D2 dopamine receptor stimulation increasing and D3 dopamine receptor activation inhibiting amphetamine-induced locomotion. We hypothesize that tolerance of D3 receptor locomotor inhibition contributes to behavioral sensitization. In order to test the hypothesis that expression of behavioral sensitization results in part from release of D3 receptor-mediated inhibition, thereby resulting in decreased response to D3 receptor agonists, we examined the effect of repetitive amphetamine administration on the behavioral response to the D3 receptor preferring agonists 7-OH-DPAT and PD 128907. D3-selective effects have recently been described for both drugs at a low dose. At 1 week following completion of a repetitive treatment regimen, amphetamine-pretreated rats displayed a decreased response to D3-selective doses of both 7-OH-DPAT and PD 128907, when compared to animals receiving saline pretreatment. Moreover, in addition to the quantitative alteration in response, there was a change in the inter-relation between response to amphetamine and D3 agonist. A highly significant inverse relation between locomotor inhibitory response to PD 128907 and the locomotor-stimulant response to amphetamine was observed prior to amphetamine treatment. In contrast, 10 days following repetitive amphetamine treatment, the relation between response to PD 128907 and amphetamine was not detected. The observed behavioral alteration could not be accounted for by changes in D3 receptor binding in ventral striatum. These findings suggest a persistent release of D3 receptor-mediated inhibitory influence contributes to the expression of behavioral sensitization to amphetamine.

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Section: Comparison With Previous Findingscontrasting

confidence: 99%

Section: Behavioral Response To Amphetamine and To D3 Receptor Agonismentioning

confidence: 98%

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Richtand

Welge

Levant

et al. 2003

Neuropsychopharmacol

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“…These individual differences have been observed both in outbred and inbred strains of mice (Ruth et al, 1988;George and Ritz, 1990;Henricks et al, 1997;Marley et al, 1998;Rocha et al, 1998). Likewise, variability in COC-induced behaviors has been observed in rats, predominantly in the propensity of rats, often initially classified as either low or high responders to novelty, to self-administer drug (Glick et al, 1994;Piazza et al, 2000), or to become behaviorally sensitized (Hooks et al, 1991a;Hooks et al, 1992;Djano and Martin-Iverson, 2000;Chefer et al, 2003). Differences in initial responsiveness of humans to cocaine also reflect both genetic and environmental influences and are one factor that determines whether or not an individual will become addicted to cocaine (Haertzen et al, 1983;Davidson et al, 1993).…”

Section: Introductionmentioning

confidence: 98%

Individual Differences in Cocaine- and Amphetamine-Induced Activation of Male Sprague–Dawley Rats: Contribution of the Dopamine Transporter

Briegleb

Gulley

Hoover

et al. 2004

Neuropsychopharmacol

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Previously we found that outbred male Sprague-Dawley rats can be classified as either low or high cocaine responders (LCRs or HCRs, respectively), based on their open-field locomotor response to acute cocaine (COC; 10 mg/kg, i.p.). Here, we extended this analysis to amphetamine (AMPH; 0.5, 1, and 5 mg/kg, i.p.) and found that the individual differences in behavioral activation were not as pronounced as with COC. This was confirmed with observational analysis of behaviors. Differences in drug-induced activation could involve differential dopamine transporter (DAT) function/trafficking. To address this possibility, we measured [ 3 H]DA uptake into dorsal striatal synaptosomes prepared from rats injected 30 min earlier with saline, COC, or AMPH to determine DAT activity, and radioligand binding to determine the total number of DATs. Striatal [ 3 H]DA uptake in COC-treated HCRs was significantly higher than in LCRs. Furthermore, regardless of LCR/HCR classification, uptake in individual COC-treated rats was significantly correlated with their locomotor behavior in the 30 min after drug administration. In contrast, AMPH-treated rats did not differ in uptake, nor were uptake and locomotor activity correlated. DAT number did not differ between LCRs or HCRs, or between AMPH-treated rats. In addition, when individual differences in COC-induced behavior were no longer detected in LCRs and HCRs 1 week after initial classification, uptake was also similar. Together, these results suggest that a difference in expression of functional DATs on the cell surface contributes to the individual differences observed in COC-induced, but not AMPH-induced, behavioral activation of rats.

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“…At low to moderate doses of stimulants, a correlation between pretreatment novelty-induced locomotion and degree of subsequent sensitization was observed in several studies (Hooks et al 1991a;1992b;1992c;Piazza et al 1989;. In some cases the relation was substantial (0.84; Hooks et al 1992c) and may be influenced by genetic variation in DA concentrations in the NAS (Cabib 1993;Camp et al 1994;Fink & Reis 1981). On the basis of this relation, we propose that the capacity of the VTA-NAS DA pathway for experience-dependent plasticity, indexed by behavioral sensitization, is modulated by stable individual differences in DA transmission in the VTA-NAS pathway, indexed by noveltyinduced locomotion.…”

mentioning

confidence: 99%

“…Individual differences in DA functioning and behavioral sensitization. A preponderance of studies suggest a strong relation between individual differences in noveltyinduced locomotion, other DA-modulated behaviors, and behavioral sensitization, although variation of results exists as a function of type of behavior (e.g., mesoaccumbensmediated versus nigrostriatally mediated motor patterns), sensitization criteria (e.g., increased locomotor activity versus a hyperactivity-stereotypy multiphasic pattern), dose level, and subject population (e.g., outbred versus inbred strains) Hooks et al 1991a;1992c;Piazza & Le Moal 1996;Piazza et al 1989;Robinson 1988). In these studies, subjects (typically rats) are selected on the basis of degree of locomotor reactivity to a novel environment, where high and low responders are defined by a median split in locomotor scores.…”

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confidence: 99%

Steps to a neurochemistry of personality

Lawrence¹,

Koepp²,

Gunn³

et al. 1999

Behav Brain Sci

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Extraversion has two central characteristics: (1) interpersonal engagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and motivation) is closely associated with extraversion. Extraversion is accordingly based on positive incentive motivation.Parallels between extraversion (particularly its agency component) and a mammalian behavioral approach system based on positive incentive motivation implicate a neuroanatomical network and modulatory neurotransmitters in the processing of incentive motivation. A corticolimbic-striatal-thalamic network (1) integrates the salient incentive context in the medial orbital cortex, amygdala, and hippocampus; (2) encodes the intensity of incentive stimuli in a motive circuit composed of the nucleus accumbens, ventral pallidum, and ventral tegmental area dopamine projection system; and (3) creates an incentive motivational state that can be transmitted to the motor system.Individual differences in the functioning of this network arise from functional variation in the ventral tegmental area dopamine projections, which are directly involved in coding the intensity of incentive motivation. The animal evidence suggests that there are three neurodevelopmental sources of individual differences in dopamine: genetic, "experience-expectant," and "experience-dependent." Individual differences in dopamine promote variation in the heterosynaptic plasticity that enhances the connection between incentive context and incentive motivation and behavior.Our psychobiological threshold model explains the effects of individual differences in dopamine transmission on behavior, and their relation to personality traits is discussed.Keywords: behavioral sensitization; dopamine; extraversion; heterosynaptic plasticity; incentive motivation; neurobiology; personality the behavioral, emotional, and motivational characteristics of extraversion. Next, we identified a mammalian behavior pattern with corresponding characteristics, as described in the psychological and ethological literatures. Once an analogous motivation was identified, animal neurobiological research provided empirical links to its neural organization and neurochemical modulation. These hypotheses were then extended to humans and subjected to empirical tests. Extraversion: Central characteristics and underlying motivationExtraversion is a higher-order trait that is derived from a set of correlated lower-order traits. The lower-order traits are measures of behavioral and emotional characteristicssuch as social dominance, positive emo...

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Individual differences in amphetamine sensitization: Dose-dependent effects

Cited by 130 publications

References 23 publications

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

Individual Differences in Cocaine- and Amphetamine-Induced Activation of Male Sprague–Dawley Rats: Contribution of the Dopamine Transporter

Steps to a neurochemistry of personality

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