Individual approach in choosing second-line targeted therapy for metastatic renal cell carcinoma

Bone is a frequent site of metastasis for a wide range of cancer types. The most common cancers that often spread to bone are prostate cancer, breast cancer and renal cell carcinoma. In this regard, the preferential bone localization of tumor cells is determined by their molecular features and attraction by bone microenvironment. Metastatic niche growth destroys the bone, and as a result, patients are suffering from symptoms also known as skeletal-related events: severe pain, fractures, progressive hypercalcemia, resulting in high rates of cancer-dependent complications. Lack in effective guidelines and management procedures in metastatic cancer therapy highlights the issues of molecular mechanism investigation. Here, we discuss about bone microenvironment and how it impacts to tumor growth, cancer progression and dormancy.

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Molecular mechanisms of osteotropic cancer metastasis (literature review)

Kovalyova

Спирина

Gorbunov

et al. 2021

Medicinskij alfavit

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Personalized approach to the treatment of metastatic kidney cancer

Alrkseeva

Гурина

Писарева

et al. 2020

Tihookeanskij medicinskij žurnal

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Objective: Develop a new organizational form of a personalized approach to assign a target therapy to the patients with metastatic nephrocellular cancer concerning its clinical and economic effectiveness.Methods: The data by cancer register of the Primorsky region were used. 446 patients are included in the register, it allowed to estimate clinical-economic effectiveness of the target therapy by studying 88 cases.Results: 5 medicines were used: sunitrib, soraphenib, bevazizumab, everolimus and pazopanib. The control of the progress of the disease and the toxicity covered 44,3% of the patients. The toxicity of the 3–4th levels were registered during the treatment by inhibitors tyrozinkinaz. The target line therapy increased expenditures by 10% and allowed to increase overall survivability to 42 months.Conclusion: An electronic register of the patients provides monitoring, optimizes expenditures and increases the availability of the target therapy up to 19,7%. Sequential therapy is reasonable and provides the increase of the overall patients’ survivability.

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Individual approach in choosing second-line targeted therapy for metastatic renal cell carcinoma

Cited by 2 publications

References 35 publications

Molecular mechanisms of osteotropic cancer metastasis (literature review)

Molecular mechanisms of osteotropic cancer metastasis (literature review)

Personalized approach to the treatment of metastatic kidney cancer

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