Individual antigenic specificity of human macroglobulins-II

Solheim, B. G.; Harboe, Morten; Deverill, Johanna

doi:10.1016/0019-2791(71)90432-0

Cited by 20 publications

(13 citation statements)

References 20 publications

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“…1) resembled that of a non-radially pulsating single white dwarf. Non-radial pulsations had never been observed in an accreting white dwarf before [except possibly a single mode in the DOV primary of the CV AM CVn (Solheim et al 1998)] it had been assumed either that accretion would keep the primaries of CVs too hot to pulsate or that helium in the accreted material would suppress pulsations. The DAV (or ZZ Cet) instability strip for (non-accreting) DAs occurs between T eff s of ∼11 000 and ∼12 500 K (Koester & Holberg 2001), depending on the mixing length prescription used to describe convection.…”

Section: The First Accreting Multimode Pulsating Starmentioning

confidence: 99%

The non-radially pulsating primary of the cataclysmic variable GW Librae

Zyl

Warner

O’Donoghue

et al. 2004

Monthly Notices of the Royal Astronomical Society

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The dwarf nova GW Librae (GW Lib) is the first cataclysmic variable (CV) discovered to have a primary in a white dwarf instability strip, making it the first multimode, non‐radially pulsating star known to be accreting. The primaries of CVs, embedded in hot, bright accretion discs, are difficult to study directly. Applying the techniques of asteroseismology to GW Lib could therefore give us an unprecedented look at a white dwarf that has undergone ∼109 yr of accretion. However, an accreting white dwarf may have characteristics sufficiently different from those of single pulsating white dwarfs to render the standard models of white dwarf pulsations invalid for its study. This paper presents amplitude spectra of GW Lib from a series of observing campaigns conducted during 1997, 1998 and 2001. We find that the dominant pulsation modes cluster at periods near 650, 370 and 230 s, which also appear in linear combinations with each other. The pulsation spectrum of GW Lib is highly unstable on time‐scales of months, and exhibits clusters of signals very closely spaced in frequency, with separations on the order of 1 μHz.

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Section: The First Accreting Multimode Pulsating Starmentioning

confidence: 99%

The non-radially pulsating primary of the cataclysmic variable GW Librae

Zyl

Warner

O’Donoghue

et al. 2004

Monthly Notices of the Royal Astronomical Society

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“…Because the accuracy of the candidate orbital periods as derived from the photometric studies of AM CVn exceeds the accuracy of our period determination using the EW light curve, we folded the data set on the two proposed orbital periods, 1028.73 s (Skillman et al 1999) and 1051.2 s (Solheim et al 1998). Both periods lie very close to the peak in our power spectrum.…”

Section: A Period Searchmentioning

confidence: 99%

“…According to Solheim et al (1998) the dominant 1051-s photometric period is the orbital period and the 1029-s period is a beat between the orbital period and the 13.38-h precession period of the accretion disc. However, Skillman et al (1999) argue that the 1029-s period is the orbital period and the 1051-s period is the beat period.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic evidence for the binary nature of AM CVn

Nelemans

Steeghs

Groot

2001

Monthly Notices of the Royal Astronomical Society

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We analysed archival spectroscopic data of AM CVn taken with the William Herschel Telescope in 1996. In the literature two orbital periods for AM CVn are proposed. A clear S-wave in the HeI 4471, 4387 and 4143 \AA lines is revealed when the spectra are folded on the 1029 s period. No signature of this S-wave is seen when folded on 1051 s. Doppler tomography of the line profiles shows a clear signature of the hotspot. Using this we can constrain the value of K_2 to lie between 210 and 280 km/s. Our work confirms the binary nature of AM CVn beyond any doubt, establishes 1028.73 s as the true orbital period and supports the interpretation of AM CVn as a permanent superhump system.Comment: Accepted by MNRA

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“…The titers against proteins 7,11, and 21 were consistently higher, and these higher titers apparently accounted for the transfer of only these specificities into the serum of the infant. The titer differences might reflect various degrees of response to a common antigenic determinant with minor steric or conformational changes between proteins 7, 11, and 21 and proteins 8 and 10.…”

Section: Discussionmentioning

confidence: 87%

“…It appears that u and L chains are required in their normal association as the 7S subunits of IgM to express the determinant although we feel that it is located in the Fc region of the M chain. The dependence of antigenicity on the association of H and L chains with intact disulfide bonds has been described for y chain allotypic markers Gm(b2), Gm(f), and Gm(z) on IgG molecules (1, 2) and for an individual antigenic specificity on the Lu chain of a monoclonal IgM M6 (11). We have thus far been unable to verify the location of the determinant in the FcMu region since the isolation procedures for the fragments apparently destroy its antigenicity in our test system.…”

Section: Discussionmentioning

confidence: 99%

Human Anti-IgM Iso-Antibodies: Detection of IgM Allotypic Markers

Wells¹,

Bleumers²,

Fudenberg³

1973

Proc. Natl. Acad. Sci. U.S.A.

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IgG class antibodies against human IgM were detected in a human subject up to a titer of 1:1024 against 5 of a group of 23 monoclonal Waldenstr-m macroglobulins. Inhibition studies confirmed at least one antigenic determinant shared by the 5 IgMs. The determinant was present on the ji chain but required tertiary structure for its full expression. Inhibition of the reaction between the antibodies to IgM and erythrocytes coated with 2 of the 5 IgMs was obtained at titers of 1:2 to 1:16 with 51.0% of 300 normal sera (85.2% of sera from 122 Caucasian, 26.1% of sera from 23 Negro, and 27.7% of sera from 155 Japanese individuals). This inhibition was independent of the serum IgM concentration. Family studies indicated that the determinant was inherited according to basic Mendelian laws and appears to be the first allotypic marker on human serum IgM. We have designated it Mm 1.Numerous studies have been reported on the inherited allotypic markers on the y-heavy chains of IgG molecules (Gm markers) and on K-type light chains (Inv markers) (1,2). An allotypic marker on the a-heavy chains of IgA molecules was studied with a human serum containing antibodies against one of a group of IgA myeloma proteins and erythrocytes coated with the specific IgA myeloma protein by the chromic chloride method (3). This marker was originally designated Am, and is probably identical to the marker Am2 on IgA2 molecules (4). It has been redesignated A2m1 with the discovery of its allele designated A2m2, by Van Loghem et al.(submitted for publication).Attempts by several laboratories over the past 10 years to detect IgM allotypic determinants by similar techniques have been less fruitful (5). Anti-IgM antibodies were detected in an earlier study in only 16 of 378 sera (4.2%), including subjects who had had multiple blood transfusions or several pregnancies (5). These antibodies were of low titer, directed in each case against only one of a group of 15 Waldenstrom macroglobulins, and slightly inhibited in two cases by some normal sera (6). We report here studies on a subject whose serum contained IgG-class antibodies in high titer against five of a group of 23 monoclonal IgM macroglobulins. Inhibition experiments indicated a specificity against one or more determinants shared by the five IgM proteins, and the evidence indicates that this shared determinant represents an inherited characteristic ("allotype"). MATERIALS AND METHODSThe chromic chloride method (6) was used to coat erythrocytes from a group 0, Rh-positive subject with purified proteins from a group including 23

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Individual antigenic specificity of human macroglobulins-II

Cited by 20 publications

References 20 publications

The non-radially pulsating primary of the cataclysmic variable GW Librae

The non-radially pulsating primary of the cataclysmic variable GW Librae

Spectroscopic evidence for the binary nature of AM CVn

Human Anti-IgM Iso-Antibodies: Detection of IgM Allotypic Markers

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