2022
DOI: 10.1530/ec-21-0474
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Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study

Abstract: Although previous studies demonstrate that trehalose can help maintain glucose homeostasis in healthy humans, its role and joint effect with glutamate on diabetic retinopathy (DR) remain unclear. We aimed to comprehensively quantify the associations of trehalose and glutamate with DR. This study included 69 pairs of DR and matched type 2 diabetic (T2D) patients. Serum trehalose and glutamate were determined via ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry system. Cov… Show more

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Cited by 3 publications
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“…Glu is associated with T2D, and studies have shown a 0.25 drop in Glu levels in diabetic subjects compared to non-diabetic controls (23). At the same time, studies have found that Glu is a risk factor for the incidence of DR (24), while another Korean study found that the intake of Glu did not affect the incidence of DR (25). We believe that in addition to the heterogeneity of the population, the metabolic interactions between amino acids should also be taken into account.…”
Section: Discussionmentioning
confidence: 99%
“…Glu is associated with T2D, and studies have shown a 0.25 drop in Glu levels in diabetic subjects compared to non-diabetic controls (23). At the same time, studies have found that Glu is a risk factor for the incidence of DR (24), while another Korean study found that the intake of Glu did not affect the incidence of DR (25). We believe that in addition to the heterogeneity of the population, the metabolic interactions between amino acids should also be taken into account.…”
Section: Discussionmentioning
confidence: 99%