Individual and combined use of ginsenoside F2 and cyanidin-3-O-glucoside attenuates H<sub>2</sub>O<sub>2</sub>-induced apoptosis in HEK-293 cells via the NF-κB pathway

Liu, Di; Wáng, Ying; Ma, S.; Sun, Hongyu; Shi, Wen‐Yan; Feng, Xiao

doi:10.1039/c7ra04689h

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…ROS and free radicals are by-products of normal cell metabolism and do not damage cells at low concentrations but contribute to interactions between cells [39]. However, at a too-high intracellular concentration, ROS and free radicals severely damage cells and tissues, which decreases the mitochondrial membrane potential and induces protein damage and DNA fragmentation [40]. In our experiments, we used the DCFH-DA fluorescent probe assay to evaluate the production and elimination of ROS in HEK293 cells.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Tian

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to have a strong synergistic antioxidant effect, and correlations between cellular antioxidant indexes and free radical scavenging ability were found. Individual and combined pretreatment with araloside A and L-ascorbic acid increased both cell viability and antioxidant enzyme activity and inhibited the release of lactate dehydrogenase (LDH); the accumulation of malondialdehyde (MDA), lipid peroxidation (LPO) products, and H2O2; and the production of intracellular reactive oxygen species (ROS), protein carbonyls, and 8-hydroxy-2-deoxy guanosine (8-OHdG). Free radical scavenging ability was positively correlated with superoxide dismutase (SOD) and catalase (CAT) activity, the glutathione (GSH)/oxidized glutathione (GSSG) ratio, and total antioxidant capacity (T-AOC). Our study is the first investigation of araloside A and L-ascorbic acid coadministration for the treatment of diseases caused by oxidative stress. The synergistic antioxidant effects of araloside A and L-ascorbic acid support their potential as functional food ingredients for the elimination of oxidative stress-induced adverse reactions.

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Section: Discussionmentioning

confidence: 99%

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Tian

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…It is also an important indicator reflecting the degree of cell apoptosis. Caspases-3 is one of the most important executors of apoptosis and an irreversible marker of apoptosis [16]. Its expression level can reflect the apoptosis of cells.…”

Section: Inhibition Of Apoptosismentioning

confidence: 99%

Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer

Jianzhang,

Shuli,

Jiyong

et al. 2024

AJHR

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Survivin is an important member of the apoptosis inhibitory protein family, which plays an important role in suppressing apoptosis, promoting proliferation and vascular formation. The occurrence and development of tumors are related to apoptosis and imbalance of proliferation. Gastric cancer is the most common malignant tumor in the digestive system. Due to the inadequate symptoms of early symptoms, most of them have entered the middle and late stages during diagnosis. It is easy to relapse and metastasize. The mortality rate is high, which seriously endangers human health. Research have found that Survivin expresses high in gastric cancer tissue, participating in the proliferation of tumor cells, inhibiting apoptosis and the formation of blood vessels, and is of great significance to the diagnosis, judgment transfer and prognosis evaluation of gastric cancer, especially the value of combined with a number of indicators is greater. Therefore, finding an early diagnosis and judging the ideal tumor logo combination of the early diagnosis and judgment of the prognosis is important. This article reviews the biological characteristics of Survivin and its research progress in gastric cancer, so as to provide theoretical basis for the diagnosis of gastric cancer and new ideas for the successful prevention and treatment of tumors.

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Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review

Oumeddour,

Al-Dalali,

Zhao

et al. 2024

Biochemical and Biophysical Research Communications

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Individual and combined use of ginsenoside F2 and cyanidin-3-O-glucoside attenuates H₂O₂-induced apoptosis in HEK-293 cells via the NF-κB pathway

Abstract: Ginsenoside F2 and cyanidin-3-O-glucoside synergistically inhibited H2O2-induced apoptosis in HEK-293 cells through mitochondria-mediated apoptotic and NF-κB pathways.

Cited by 4 publications

References 53 publications

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer

Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review

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Individual and combined use of ginsenoside F2 and cyanidin-3-O-glucoside attenuates H2O2-induced apoptosis in HEK-293 cells via the NF-κB pathway

Abstract: Ginsenoside F2 and cyanidin-3-O-glucoside synergistically inhibited H2O2-induced apoptosis in HEK-293 cells through mitochondria-mediated apoptotic and NF-κB pathways.

Cited by 4 publications

References 53 publications

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H2O2‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H2O2‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Research Progress of Apoptosis Inhibitory Protein Survivin in Gastric Cancer

Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review

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Product

Resources

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Individual and combined use of ginsenoside F2 and cyanidin-3-O-glucoside attenuates H₂O₂-induced apoptosis in HEK-293 cells via the NF-κB pathway

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status