Individual and combined cytotoxicity of major trichothecenes type B, deoxynivalenol, nivalenol, and fusarenon-X on Jurkat human T cells

Aupanun, Sawinee; Phuektes, Patchara; Poapolathep, Saranya; Alassane-Kpémbi, Imourana; Oswald, Isabelle P.; Poapolathep, Amnart

doi:10.1016/j.toxicon.2019.02.006

Cited by 12 publications

(4 citation statements)

References 47 publications

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“…The few publications describing the toxicity of NIV metabolites, usually only include fusarenone X (FUS-X) and found that this compound has similar or slightly lower toxicity compared to its native form. These observations were confirmed in GES-1 cell lines and human T cells (Jurkat Cells) [ 77 , 89 ]. Mouse studies demonstrated significantly greater DNA fragmentation in the thymus gland, Peyer’s patches and spleen in animals exposed to FUS-X than in those exposed to NIV [ 90 ].…”

Section: Toxicologymentioning

confidence: 69%

Recent Research on Fusarium Mycotoxins in Maize—A Review

Bryła

Pierzgalski

Zapaśnik

et al. 2022

Foods

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Maize (Zea mays L.) is one of the most susceptible crops to pathogenic fungal infections, and in particular to the Fusarium species. Secondary metabolites of Fusarium spp.—mycotoxins are not only phytotoxic, but also harmful to humans and animals. They can cause acute or chronic diseases with various toxic effects. The European Union member states apply standards and legal regulations on the permissible levels of mycotoxins in food and feed. This review summarises the most recent knowledge on the occurrence of toxic secondary metabolites of Fusarium in maize, taking into account modified forms of mycotoxins, the progress in research related to the health effects of consuming food or feed contaminated with mycotoxins, and also the development of biological methods for limiting and/or eliminating the presence of the same in the food chain and in compound feed.

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Section: Toxicologymentioning

confidence: 69%

Recent Research on Fusarium Mycotoxins in Maize—A Review

Bryła

Pierzgalski

Zapaśnik

et al. 2022

Foods

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“…122 In Jurkat T cells, a strong antagonistic effect was observed for the mixture of DON (6.98 μM) and nivalenol (4.71 μM), and the mixture of DON (5.56 μM) and fusarenon-x (9.14 μM) exhibited moderate antagonism. 123 In conclusion, the effects of DON combined with other toxins are complex, and the immunotoxicity of multiple mycotoxin contamination cannot be predicted based on individual effects but depends on the combination, proportion, and/or concentration of each mycotoxin and the type of target cells. Therefore, studying the comprehensive toxicity of multiple mycotoxins rather than the toxicity of a single mycotoxin is valuable to develop more effective drugs to inhibit mycotoxins.…”

Section: Combined Toxicity Of Don and Other Mycotoxinsmentioning

confidence: 99%

“…Following the combined treatment with DON (2 mg/kg) and ZEN (20 mg/kg), the levels of alkaline phosphatase, alanine aminotransferase, and albumin/globulin in blood exhibited a moderated trend and the analysis of metabolic pathways showed that the biosynthesis of valine, leucine, and isoleucine in liver tissues had also decreased . In Jurkat T cells, a strong antagonistic effect was observed for the mixture of DON (6.98 μM) and nivalenol (4.71 μM), and the mixture of DON (5.56 μM) and fusarenon-x (9.14 μM) exhibited moderate antagonism …”

Section: Combined Toxicity Of Don and Other Mycotoxinsmentioning

confidence: 99%

Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives

Deng

Wang

et al. 2023

J. Agric. Food Chem.

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Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and feed, causing a variety of toxic effects in humans and animals. Currently, a series of mechanisms involved in DON toxicity have been identified. In addition to the activation of oxidative stress and the MAPK signaling pathway, DON can activate hypoxia-inducible factor-1α, which further regulates reactive oxygen species production and cancer cell apoptosis. Noncoding RNA and signaling pathways including Wnt/β-catenin, FOXO, and TLR4/NF-κB also participate in DON toxicity. The intestinal microbiota and the brain–gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect of DON and other mycotoxins, strategies to detect DON and control it biologically and the development of enzymes for the biodegradation of various mycotoxins and their introduction in the market are the current and future research hotspots.

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“…Similarly to Loewe's additivity model, the isobologram can be constructed. The Chou-Talalay model combined with an isobologram has been applied in the majority of the recently published studies [39,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] listed in Table 2. Its great advantage is the recent development of a method for the estimation of confidence intervals for the combination index which enables the application of statistics [66].…”

Section: Chou and Talalay's Median Effect Approachmentioning

confidence: 99%

Assessing the Effect of Mycotoxin Combinations: Which Mathematical Model Is (the Most) Appropriate?

Kifer

Jakšić

Klarić

2020

Toxins

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In the past decades, many studies have examined the nature of the interaction between mycotoxins in biological models classifying interaction effects as antagonisms, additive effects, or synergisms based on a comparison of the observed effect with the expected effect of combination. Among several described mathematical models, the arithmetic definition of additivity and factorial analysis of variance were the most commonly used in mycotoxicology. These models are incorrectly based on the assumption that mycotoxin dose-effect curves are linear. More appropriate mathematical models for assessing mycotoxin interactions include Bliss independence, Loewe’s additivity law, combination index, and isobologram analysis, Chou-Talalays median-effect approach, response surface, code for the identification of synergism numerically efficient (CISNE) and MixLow method. However, it seems that neither model is ideal. This review discusses the advantages and disadvantages of these mathematical models.

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Individual and combined cytotoxicity of major trichothecenes type B, deoxynivalenol, nivalenol, and fusarenon-X on Jurkat human T cells

Cited by 12 publications

References 47 publications

Recent Research on Fusarium Mycotoxins in Maize—A Review

Recent Research on Fusarium Mycotoxins in Maize—A Review

Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives

Assessing the Effect of Mycotoxin Combinations: Which Mathematical Model Is (the Most) Appropriate?

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