Individual 17-Ketosteroid Excretion in a Case of Arrhenoblastoma and Its Response to Corticotrophin and Human Chorionic Gonadotrophin Stimulation and to Dexamethasone Inhibition

Pathophysiology and Evaluation of Adrenal Hyperandrogenism

“…For example, there have been several reports of gonadotropin-responsive adrenal tumors. [221][222][223]225,228,237,292 The possibilities of gonadotropin-stimulated adrenal androgen biosynthesis [293][294][295][296][297][298][299] or of ACTH-stimulated ovarian androgen biosynthesis 300,301 have also been questioned. Similarly, dexamethasone-suppressibility of serum T has been plagued by questions of specificity and is still the subject of an ongoing controversy.…”

Clinical Evaluation of Androgen Excess

“…The test does not consistently differentiate between a functional or neoplastic disorder and therefore should not be used for that purpose. Some adrenal tumors, and even the rare ovarian tumor, 90 may be associated with elevated 17-OHP concentrations that respond to ACTH.…”

The hormone pattern in a case of arrhenoblastoma

“…Between 1965 and the present day a further 6 cases under 18 years have been reported in literature (Okun 1965;Ehrlich et al 1968;Goldstein and Lamb 1970;Mahesh et al 1970;Greenblatt et al 1972 Few detailed hormonal studies have appeared even in patients over 18 years old; plasma testosterone has been found to be elevated (Mahesh et al 1970;Greenblatt et al 1972;Tucci et al 1973) and urinary 17 KS normal or high (Podowitz and O'Brien 1960;Gallagher et al 1962;Louros et al 1966). …”