Indium‐promoted Conversion of Allylic Bromide to Alcohol Moiety and Synthesis of Pipermethystine Skeletons

Abstract

Dihydropyridone bromide (2) was converted to the corresponding alcohol (1) by reaction with indium in air or with indium followed by treatment with a sulfonyloxaziridine. The alcohol (1) was transformed in four steps to a phenylsulfone‐substituted pipermethystine derivative (10). Reductive cleavage of the phenylsulfone did not yield the pipermethystine natural product. Several new pyridone derivatives were synthesized.