Indium(III) and Gallium(III) Complexes of Bis(aminoethanethiol) Ligands with Different Denticities:  Stabilities, Molecular Modeling, and in Vivo Behavior

Radiosynthesis and Biological Evaluation of 68Ga-Labeled Colchicine Conjugates

“…27 Hexadentate NOTA is an ideal chelating agent for 68 Ga as the small cavity size of triazanonane ring matches with the small ionic radius of 68 Ga 3 + ion (62 pm) resulting in formation of more thermodynamically stable complex than 68 Ga-DOTA. 28 On the other hand, since DOTA is known to be an ideal chelator for complexation with other trivalent metallic radionuclides ( 177 Lu + 3 and 90 Y + 3 ), the preparation of 68 Ga-DOTA-colchicine radiotracer in high yield indicates its possible application in radionuclide therapy after conjugation with trivalent radiolanthanides. 68 Ge/ 68 Ga generator eluate purified using cationexchange column was used for 68 Ga labeling.…”

Molecular Imaging Kits for Hexosamine Biosynthetic Pathway in Oncology

“…Therefore, L,L-ethylenedicysteine (EC) is the most successful example of N 2 S 2 chelates [30][31][32][33] of this combination. In addition, EC can be labeled with radiometals efficiently with high radiochemical purity and the preparation remains stable for several hours [34][35][36]. The strong complexing property of such N 2 S 2 -tetraligand systems is also used for labeling of proteins and peptides with radiometals for theranostic applications after conjugation to a bisaminothiol derivative [37][38][39].…”

Challenges and Opportunities in Molecular Imaging

“…L,L-ethylenedicysteine (EC) is a successful example of N 2 S 2 chelates [16]. EC has been extensively labeled with 99m Tc in an efficient manner, with high radiochemical purity and the preparation remains stable for several hours [17][18][19][20][21][22][23][24][25][26][27]. In addition to assessing molecular targets, development of 99m Tc-agents may be useful in planning internal targeted radionuclide therapy with betaemitting radionuclides such as 188 Re.…”