Indium

Maples-Reynolds, Nikki; Nakano, Makiko; Fowler, Bruce A.

doi:10.1016/b978-0-12-822946-0.00014-3

Cited by 1 publication

(3 citation statements)

References 132 publications

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“…Al, Ga, and In have no known biological roles and have been shown to be toxic to plants 14–18 and microbes, 1 and to have adverse health effects on humans and experimental animals. 6 , 7 , 11 , 12 In exposure in occupational settings can damage the liver and spleen, and result in lung disease and renal failure in humans. 7 , 12 , 19 On the cellular level, In appears to target the endoplasmic reticulum (ER) and haem metabolism.…”

Section: Introductionmentioning

confidence: 99%

“… 6 , 7 , 11 , 12 In exposure in occupational settings can damage the liver and spleen, and result in lung disease and renal failure in humans. 7 , 12 , 19 On the cellular level, In appears to target the endoplasmic reticulum (ER) and haem metabolism. 7 , 12 , 20 Ga-containing compounds can affect the lungs, the kidney, and the immune and hematopoietic systems in experimental animals.…”

Section: Introductionmentioning

confidence: 99%

“… 7 , 12 , 19 On the cellular level, In appears to target the endoplasmic reticulum (ER) and haem metabolism. 7 , 12 , 20 Ga-containing compounds can affect the lungs, the kidney, and the immune and hematopoietic systems in experimental animals. 11 At the cellular level, Ga causes increased levels of reactive oxygen species, perturbs iron (Fe) homeostasis and Fe-dependent processes, and inhibits ribonucleotide reductase, a key enzyme in DNA synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Chemical-genomic profiling identifies genes that protect yeast from aluminium, gallium, and indium toxicity

Schulze,

Ghiaci,

Zhao

et al. 2023

Metallomics

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Aluminium, gallium, and indium are group 13 metals with similar chemical and physical properties. While aluminium is one of the most abundant elements in the Earth's crust, gallium and indium are present only in trace amounts. However, the increased use of the latter metals in novel technologies may result in increased human and environmental exposure. There is mounting evidence that these metals are toxic, but the underlying mechanisms remain poorly understood. Likewise, little is known about how cells protect themselves from these metals. Aluminium, gallium, and indium are relatively insoluble at neutral pH, and here we show that they precipitate in yeast culture medium at acidic pH as metal-phosphate species. Despite of this, the dissolved metal concentrations are sufficient to induce toxicity in the yeast Saccharomyces cerevisiae. By chemical-genomic profiling of the S. cerevisiae gene deletion collection, we identified genes that maintain growth in the presence of the three metals. We found both shared and metal-specific genes that confer resistance. The shared gene-products included functions related to calcium metabolism and Ire1/Hac1-mediated protection. Metal-specific gene-products included functions in vesicle-mediated transport and autophagy for aluminium, protein folding and phospholipid metabolism for gallium, and chorismate metabolic processes for indium. Many of the identified yeast genes have human orthologues involved in disease processes. Thus, similar protective mechanisms may act in yeast and humans. The protective functions identified in this study provides a basis for further investigations into toxicity and resistance mechanisms in yeast, plants, and humans.

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