Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Tobias Gustavsson,
Matthias M. Herth,
Dag Sehlin
et al.
Abstract:Background: The development of bispecific antibodies that can traverse the blood–brain barrier has paved the way for brain-directed immunotherapy and when radiolabelled, immunoPET imaging. The objective of this study was to investigate how indium-111 (111In) radiolabelling with compatible chelators affects the brain delivery and peripheral biodistribution of the bispecific antibody RmAb158-scFv8D3, which binds to amyloid-beta (Aβ) and the transferrin receptor (TfR), in Aβ pathology-expressing tg-ArcSwe mice an… Show more
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