Indium 111—labeled platelet deposition in woven and knitted Dacron bifurcated aortic grafts with the same patient as a clinical model

Robicsek, Francis; Duncan, Gordon D.; Anderson, Carl E.; Daugherty, Harry K.; Cook, Joseph W.; Selle, Jay G.; Hess, Philip J.; Easton, Edward J.; Burtoft, John N.

doi:10.1016/0741-5214(87)90095-4

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Platelet aggregation and thrombus formation play a key role in early as well as intermediate failures. Autologous radiolabelled platelets have proved valuable in the assessment of platelet deposition after balloon angioplasty (Minar et al, 1987;Stratton, 1991), thrombendarterectomy (Stratton et al, 1987) or graft insertion (Goldman et al, 1982a;Robicsek et al, 1987;Smyth et al, 1995) and in the evaluation of antiplatelet treatment after vascular interventions (Goldman et al, 1983;Stratton & Ritchie, 1986).…”

Section: Introductionmentioning

confidence: 99%

Scintigraphic assessment of focal platelet accumulations following infrainguinal bypass surgery in humans

Nielsen

Hesse

Eiberg

et al. 1997

Clinical Physiology

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Enothelial injury is assumed to be of pathogenetic significance in the development of graft stenoses, which remain a major cause of failure of peripheral bypasses. The aim of this study was to assess endothelial injury related to infrainguinal bypass surgery by indium-111 platelet scintigraphy. In 28 patients undergoing in situ vein (n = 24), composite vein-polytetrafluoroethylene (PTFE) (n = 1) or PTFE (n = 3) bypass surgery, assumed vascular injuries were recorded intraoperatively. Autologous indium-111-labelled platelets were injected into the inflow artery immediately after restoration of flow in the graft. Platelet deposition was assessed by gamma-camera images of thigh and crus obtained 4 and/or 24 h after surgery. Areas of focally increased activity were recorded and graded as moderate or intense. In the 24 vein bypasses, a median of two (range 0-5) areas of focally increased radioactivity were seen at the proximal anastomosis (n = 21), in the body of the graft (n = 20) or at the distal anastomosis (n = 9). The activity was moderate in 27 cases and intense in 23 cases. Scintigraphic evidence of focal platelet aggregation in vein grafts was not correlated with preoperative antiplatelet therapy or vein graft diameter. Only 2 of the 20 intragraft platelet depositions occurred in areas where intra-operative vascular injury was suspected. In the composite graft and the PTFE grafts, diffuse activity was observed throughout the entire bypass. In conclusion, focal activity accumulations, suggesting localized endothelial injury, were observed in the majority of in situ vein bypasses, in particular at the sites of the anastomoses. Prosthetic bypasses were characterized by diffuse platelet aggregation.

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Section: Introductionmentioning

confidence: 99%

Scintigraphic assessment of focal platelet accumulations following infrainguinal bypass surgery in humans

Nielsen

Hesse

Eiberg

et al. 1997

Clinical Physiology

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“Half and Half” Woven and Knitted Dacron Grafts in the Aortoiliac and Aortofemoral Positions: Seven and One-Half Years Follow-Up

Robicsek

Duncan

Daugherty

et al. 1991

Annals of Vascular Surgery

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Platelet reactivity in human aortic grafts: A prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

Wakefield

Shulkin

Fellows

et al. 1989

Journal of Vascular Surgery

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Platelet-related phenomena at the blood-surface interface of randomly placed knitted Dacron (n = 6) and polytetrafluoroethylene (ePTFE) (n = 6) interposition aortic grafts were studied in patients undergoing abdominal aortic aneurysmectomy. Luminal accumulation of platelets was assessed by infusing indinm-lll-oxine (400 ~Ci) labeled autologous platelets and imaging grafts at 1 week, 3 months, and 6 months after surgery. Image analysis included an indium ratio technique (comparing aortic graft radioactivity to that of an lilac artery) and a red blood cell technetium subtraction technique (excluding blood pool radioactivity from graft radioactivity, with the heart or iliac artery serving as reference regions). Plasma levels of [3-thromboglobulin and platelet factor 4 were correlated with platelet accumulations on the aortic prostheses. Differences in graft radioactivity or platelet-release products were not evident 1 week after surgery. Three months after implantation, Dacron and ePTFE conduits exhibited 87% and 47% (p < 0.05) more radioactivity with the indium ratio technique than the iliac artery. Similary, increased Dacron compared with ePTFE graft radioactivity was noted using technetium subtraction techniques: 71% vs 30% with a heart reference and 26% vs 11% with an iliac artery reference, respectively. Increases in graft radioactivity correlated with increases in both plasma I~-thromboglobulin and platelet factor 4 at 3 months (r = 0.6 to 0.9; p < 0.05 to 0.001 depending on the imaging technique used). At 6 months, differences did not persist. In fact, technetium subtraction techniques suggested less Dacron conduit reactivity. It is speculated that differences in platelet accumulation and activation associated with different graft substrates may prove clinically important.

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Indium 111—labeled platelet deposition in woven and knitted Dacron bifurcated aortic grafts with the same patient as a clinical model

Cited by 4 publications

References 15 publications

Scintigraphic assessment of focal platelet accumulations following infrainguinal bypass surgery in humans

Scintigraphic assessment of focal platelet accumulations following infrainguinal bypass surgery in humans

“Half and Half” Woven and Knitted Dacron Grafts in the Aortoiliac and Aortofemoral Positions: Seven and One-Half Years Follow-Up

Platelet reactivity in human aortic grafts: A prospective, randomized midterm study of platelet adherence and release products in Dacron and polytetrafluoroethylene conduits

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