Indium-111 labeled leukocyte accumulation in extremity soft tissue sarcoma

Abstract

Nuclear medicine labeled leukocyte whole-body scintigraphy is commonly used to identify a source of infection in a patient with fever of unknown origin. White blood cells can also localize to other sites of inflammation, including sometimes tumors. A patient with a large myxofibrosarcoma in his left forearm was scanned due to chronic low-grade fever and persistent leukocytosis. This case demonstrates focal white blood cell activity in an extremity soft tissue sarcoma.

Necrotizing fasciitis: are tagged-WBC scans underutilized?

“…The tagged cells will localize to the source of infection, which can be seen on subsequent scanning. In-111 WBC scan has been shown to aid in the diagnosis of infection, particularly osteomyelitis and vascular graft infections, as well as in soft tissue sarcoma and neoplasm [1][2][3][4][5]. This case report details the use of In-111 WBC scan to diagnose necrotizing fasciitis, which is historically not a typical use of In-111 WBC scan.…”