Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies

Xiao, Chi; Wang, Liqing; Ren, Yuping; Sun, Shen; Zhang, Erlin; Yan, Chongnan; Liu, Qi; Sun, Xiaogang; Shou, Fenyong; Duan, Jingzhu; Wang, Huang; Qin, Gaowu

doi:10.1016/j.jmst.2018.01.006

Cited by 150 publications

(109 citation statements)

References 41 publications

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“…Development of binary Zn alloys continued with notable works by Zheng and co-workers [87,88] on Zn-Mg, as well as zinc-calcium (Zn-Ca), and zincstrontium (Zn-Sr) alloys. Other reports on Zn-Mg include those by Kubasek et al [55,89,90], Yao et al [91],Gong et al [92], Murni et al [93], Shen et al [94], Galib and Sharif [95], Mostaed et al [96], Jablonska et al [97], Dambatta et al [98,99], Vida et al [100], Jarzebska et al [101], Jin et al [102], Xiao et al [103], Alves et al [104], Wang et al [105], and Yang et al [78]. The range of Mg addition typically ranged from 1 to 3 wt%; though relatively high (>5%) [90] and low (<0.1 wt%) [102,103] alloy additions of Mg have also been reported.…”

Section: Binary Alloysmentioning

confidence: 99%

“…The elongated cylindrical profile typical of a tube may be created via extrusion [19,66,87,94,96,103,105,106,110,112] or drawing [75,107,114]. Extrusion involves pushing the metal through a die with an orifice of the desired shape.…”

Section: Traditional Wrought Techniquesmentioning

confidence: 99%

“…Potentiodynamic polarisation experiments involve the classic three-electrode apparatus consisting of a working electrode (the tested metal), a reference electrode (e.g., standard calomel electrode) and a counter electrode (e.g., platinum). Typically, the test electrolyte is a fluid that mimics the physiological environment, such as the balanced salt solutions (BSS) like Ringer's (RBSS) and Hanks', phosphate-buffered saline (PBS) solution, and simulated body fluid (SBF) [103]. In some degradation tests, actual human plasma and whole blood were used [81].…”

Section: Assessment Of Biocorrosion and Biocompatibilitymentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Zinc has been identified as one of the most promising biodegradable metals along with magnesium and iron. Zinc appears to address some of the core engineering problems associated with magnesium and iron when applied to biomedical implant applications; hence the increase in the amount of research investigations on the metal in the last few years. In this review, the current state-of-the-art on biodegradable Zn, including recent developments, current opportunities and future directions of research are discussed. The discussions are presented with a specific focus on reviewing the relationships that exist between mechanical properties, biodegradability, and biocompatibility of zinc with alloying and fabrication techniques. This work hopes to guide future studies on biodegradable Zn that will help in advancing this field of research. Statement of Significance (i) The review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn; (ii) the work cites the most relevant biodegradable Zn fabrication processes including additive manufacturing techniques; (iii) the review includes a listing of research gap and future research directions for the field of biodegradable Zn.

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Section: Binary Alloysmentioning

confidence: 99%

Section: Traditional Wrought Techniquesmentioning

confidence: 99%

Section: Assessment Of Biocorrosion and Biocompatibilitymentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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“…In particular, Zn is an effective alloying element that can improve the mechanical properties of magnesium alloys [15][16][17] . Hence, high strength Mg-Zn alloys have a broad application prospect in many fields [18][19][20][21] .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Strain hardening of as-extruded Mg-xZn (x = 1, 2, 3 and 4 wt%) alloys

Zhao

Chen

Pan

et al. 2019

Journal of Materials Science & Technology

112

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The influence of Zn on the strain hardening of as-extruded Mg-xZn (x = 1, 2, 3 and 4 wt%) magnesium alloys was investigated using uniaxial tensile tests at 10-3 s-1 at room temperature. The strain hardening rate, the strain hardening exponent and the hardening capacity were obtained from true plastic stress-strain curves. There were almost no second phases in the as-extruded Mg-Zn magnesium alloys. Average grain sizes of the four as-extruded alloys were about 17.8 μm. With increasing Zn content from 1 2 to 4 wt%, the strain hardening rate increased from 2850 MPa to 6810 MPa at (σ-σ0.2) = 60 MPa, the strain hardening exponent n increased from 0.160 to 0.203, and the hardening capacity, Hc increased from 1.17 to 2.34. The difference in strain hardening response of these Mg-Zn alloys might be mainly caused by weaker basal texture and more solute atoms in the α-Mg matrix with higher Zn content.

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“…A wide range of composition has been explored without a clear design principle 14,15 . For bone implants, limited publications have focused on only three alloy systems including Zn-Mg, Zn-Ca, and Zn-Sr alloys 9,[16][17][18][19] . Moreover, in vitro methodology has been performed predominantly in these studies.…”

mentioning

confidence: 99%

Alloying design of biodegradable zinc as promising bone implants for load-bearing applications

et al. 2020

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Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than biodegradable polymers, yet their strength is roughly less than 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro and in vivo studies. Li exhibits the most effective strengthening role in Zn, followed by Mg. Alloying leads to accelerated degradation, but adequate mechanical integrity can be expected for Zn alloys when considering bone fracture healing. Adding elements Mg, Ca, Sr and Li into Zn can improve the cytocompatibility, osteogenesis, and osseointegration. Further optimization of the ternary Zn-Li alloy system results in Zn-0.8Li-0.4Mg alloy with the ultimate tensile strength 646.69 ± 12.79 MPa and Zn-0.8Li-0.8Mn alloy with elongation 103.27 ± 20%. In summary, biocompatible Znbased BMs with strength close to pure Ti are promising candidates in orthopedics for loadbearing applications.

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Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies

Cited by 150 publications

References 41 publications

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

Strain hardening of as-extruded Mg-xZn (x = 1, 2, 3 and 4 wt%) alloys

Alloying design of biodegradable zinc as promising bone implants for load-bearing applications

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