Indirect Way for the Assay of Captopril Drug in Dosage FormsUsing1,10-Phenanthroline as a Selective Spectrophotometric Agent for Fe(II) Via Homemade CFIA /Merging Zones Technique

Qassim, Bushra B.; Alwan, Ahmed A .

doi:10.30526/2017.ihsciconf.1879

Cited by 4 publications

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“…The prepared samples have been left at 10, R.T (23°C), and 40°C for many periods of time, the figures below (6) show that R.T is the optimum in all cases.…”

Section: Effect Of Temperaturementioning

confidence: 98%

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Determination of the Antihypertensive Drugs Captopril, Atenolol, and Metoprolol in Dosage Forms

H. Ibrahim,

Sh. Mahmood

2024

Jurnal Teknologi

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Three antihypertensive drugs Captopril (CPL), Atenolol (ATL), and Metoprolol (MTL) have been estimated sensitively and selectively by a single spectrophotometric method using neutral red dye NLR. The method is based on oxidation of the drugs by known excess of N-bromosuccinamide (NBS) in the first reaction step followed by the oxidation of NLR dye with the exceed ed amount of NBS, as the concentration of the drug compounds increase, the color of the dye increase, the dye exhibits absorbance peak at 523 nm. The linearity range was from 1 to 10 µg/ml for the three drugs, the molar absorptivity values were 2.1164 × 105, 1.9202× 104, and 57.934× 104 l.mol-1.cm-1 for CPL, ATL, and MTL respectively, the sensitivity index of Sand’ll were 0.0102, 0.0138, and 0.01182 µg/cm2 for CPL, ATL, and MTL respectively. LOD values for the three drugs ranged from 0.00405 to 0.00547 and LOQ values were ranged from 0.0135 to 0.0182 respectively, the method exhibits good applicability to the dosage forms and high confidence as compared with standard method and standard addition method.

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“…The prepared samples have been left at 10, R.T (23°C), and 40°C for many periods of time, the figures below (6) show that R.T is the optimum in all cases.…”

Section: Effect Of Temperaturementioning

confidence: 98%

“…Approximately 3% of captopril is excreted as disulfide and approximately 30% as polar metabolites [3,4]. Captopril has been determined by flow injection [5,6] spectrophotometric via oxidation with potassium iodate in acidic [7] or spectrophotometric coupled with cloud-point extraction [8] and by chromatographic methods [9,10].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Antihypertensive Drugs Captopril, Atenolol, and Metoprolol in Dosage Forms

H. Ibrahim,

Sh. Mahmood

2024

Jurnal Teknologi

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“…The stoichiometry of the drug to reagent (1:1). According to the relationship, the reaction between FUR and OPh proceeds: While As, Am are the absorbance values of the aqueous solution, which include a sufficient and stoichiometric quantity of reagent [23,24], C is the molar concentration, and K is the stability constant, where (α) expresses the degree of disintegration (M) of the product, which is equivalent to the concentration of FUR. Where The (ΔG value) spontaneous of complex formation reaction was determined based on K evaluation as in Table 2 and the equation( ΔG = -RT lnK) where(ΔG), (R), (T) its mean gibbs free energy, general constant of gases (8.314 J. mol -1 .…”

Section: Stable Calculationsmentioning

confidence: 99%

A Novel Approach of CFIA Technique for Assaying of Furosemide (Sulfa Drug) as Antibacterial Agent in Pharmaceutical and Biological Samples Using Potassium Ferricyanide as Oxidizing Agent

Ajam,

Basheer

2023

IHJPAS

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Furosemide drug determination in pharmaceutical and biological urine samples using a novel continuous flow-injection analysis technique that is simple, rapid, sensitive and economical. The complex formed by the reaction of furosemide and O-phenylenediamine with oxidative agent K3[Fe(CN)6] to produce an orange-yellow colored product at 460 nm was the basis for the proposed method. The proposed method’s linearity ranges (3-100) μg.mL-1and (1-50) μg.mL-1 for CFIA/merging zone methods and batch .The detection limit and Limit of quantification values were 2.7502 μg.mL-1 and 9.1697 μg.mL-1 the relative standard deviation was 0.7143 %, and the average recovery is 98.80% with a verified sample throughput of 73 h-1 . The new approach was effectively employed to determination of furosemide the presence of in the pure, biological, and pharmaceutical samples.

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“…Arterial hypertension is one of the most prevalent diseases in the world [1,2] due to many factors, including those related to old age, family medical history, weight gain, stress, psychological stress, excessive salt intake, excessive drinking of alcohol, smoking In addition to other reasons [3,4]. This necessitated the search for effective medications to treat this disease; the first controlled therapy used in the treatment of arterial hypertension was captopril [5].…”

Section: Introductionmentioning

confidence: 99%

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

Jabbar,

Mezaal

2024

IHJPAS

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The determination of captopril (CAP) using a new continuous flow injection analysis (CFIA) method was given in this work CAP in its pure state and some of its pharmaceutical preparations. The technique can be described as simple, fast, sensitive, easy to operate, and low-cost. The CAP reacted with ammonium ceric(IV) sulfate (ACS)2(NH4 )2SO4Ce(SO4)2. 3 H2O in an acidic medium and the reaction led to the formation of a white, slightly yellowish precipitate. The formed precipitate was studied using Ayah 6S×1-ST-2D Solar cell-CFI Analyzer, a through the reflection of accident light on the surfaces of the precipitate particles at (0-1800), expressed as the response of the transducer measured in (mV). Some chemical and physical parameters were studied to provide the optimal conditions for the study. The calibration curve within the range of (0.07-3.0) mmol/L was linear, with a correlation coefficient (r) value equal to (0.9983), and the percentage value of linearity (R2%) was (99.65). The method's detection limit (L.O.D.) of the new method was 272.5 ng/25 µL; it was calculated by diluting the minimum concentration in the calibration curve gradually. RSD% was less than 0.2% for 0.9, 1.5, and 3.0 mmol/L concentrations of C.A.P. for n=8. The method was successfully applied to estimate C.A.P. in three pharmaceutical preparations, each produced by a different company. The new method was compared with the UV-Spectrophotometric method (classical method) at λmax= 207.2 nm by using the method of standard additions. Both the t-test and the F-test were conducted to ensure that there wasn't a significant difference between the new method and the conventional one. The results of both tests showed, at a confidence level of 95%, that there was no significant difference.

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Indirect Way for the Assay of Captopril Drug in Dosage FormsUsing1,10-Phenanthroline as a Selective Spectrophotometric Agent for Fe(II) Via Homemade CFIA /Merging Zones Technique

Cited by 4 publications

References 0 publications

Determination of the Antihypertensive Drugs Captopril, Atenolol, and Metoprolol in Dosage Forms

Determination of the Antihypertensive Drugs Captopril, Atenolol, and Metoprolol in Dosage Forms

A Novel Approach of CFIA Technique for Assaying of Furosemide (Sulfa Drug) as Antibacterial Agent in Pharmaceutical and Biological Samples Using Potassium Ferricyanide as Oxidizing Agent

Fast New Method for Estimation of Captopril in Pure and Pharmaceutical Preparation by Reaction with Ammonium Ce (IV) Sulfate in Acid Medium

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