Indirect vs direct assessment of gastric emptying: A randomized crossover trial comparing C‐isotope breath analysis and <scp>MRI</scp>

Camps, Guido; Mars, Monica; Witteman, Ben J.M.; Graaf, C. de; Smeets, Paul A.M.

doi:10.1111/nmo.13317

Cited by 16 publications

(13 citation statements)

References 40 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Independent of intervention or time, gastric emptying of the solid meal was uniformly overestimated, a known limitation of indirect breath test fitting. 51 Yet, the unfitted percentage of 13 C recovery was unchanged after AXOS intervention compared to placebo (Supplemental Figure 3). Stool frequency, stool weight, stool moisture, and fasting H 2 remained unchanged, however, BSS scores increased from harder stool type 1-2 toward softer stool types 3-4 after AXOS intervention ( Table 2, Supplemental Figure 4).…”

Section: Softer Stool Consistency But No Changes In Whole Gut Transitmentioning

confidence: 94%

Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit

et al. 2020

View full text Add to dashboard Cite

Acute intake of the wheat bran extract Arabinoxylan-Oligosaccharide (AXOS) modulates the gut microbiota, improves stool characteristics and postprandial glycemia in healthy humans. Yet, little is known on how long-term AXOS intake influences gastrointestinal (GI) functioning, gut microbiota, and metabolic health. In this randomized, placebo-controlled, double-blind study, we evaluated the effects of AXOS intake on GI function and metabolic health in adults with slow GI transit without constipation. Forty-eight normoglycemic adults were included with whole-gut transit time (WGTT) of >35 h receiving either 15 g/day AXOS or placebo (maltodextrin) for 12-wks. The primary outcome was WGTT, and secondary outcomes included stool parameters, gut permeability, short-chain fatty acids (SCFA), microbiota composition, energy expenditure, substrate oxidation, glucose, insulin, lipids, gut hormones, and adipose tissue (AT) function. WGTT was unchanged, but stool consistency softened after AXOS. 12-wks of AXOS intake significantly changed the microbiota by increasing Bifidobacterium and decreasing microbial alpha-diversity. With a good classification accuracy, overall microbiota composition classified responders with decreased WGTT after AXOS. The incretin hormone Glucagon-like protein 1 was reduced after AXOS compared to placebo. Energy expenditure, plasma metabolites, AT parameters, SCFA, and gut permeability were unchanged. In conclusion, intake of wheat bran extract increases fecal Bifidobacterium and softens stool consistency without major effects on energy metabolism in healthy humans with a slow GI transit. We show that overall gut microbiota classified responders with decreased WGTT after AXOS highlighting that GI transit and change thereof were associated with gut microbiota independent of Bifidobacterium. NCT02491125 ARTICLE HISTORY

show abstract

Section: Softer Stool Consistency But No Changes In Whole Gut Transitmentioning

confidence: 94%

Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit

et al. 2020

View full text Add to dashboard Cite

show abstract

“…There are various other techniques to assess GE rate, but the most common approaches are either indirect (C-isotope breath analysis and paracetamol absorption test), or involve the use of ionising radiation (gamma scintigraphy (72) ). Advantages of MRI are that it is well suited for individual GE assessment and less dependent on the food matrix than indirect tracer-based methods such as C-isotope breath analysis (73) . Quantification of postprandial volume changes with MRI has been shown to have low inter-observer variability, unless the stomach is nearly empty (74) .…”

Section: In Vivo Mri: Gastric Contentsmentioning

confidence: 99%

Monitoring food digestion with magnetic resonance techniques

et al. 2020

View full text Add to dashboard Cite

This review outlines the current use of magnetic resonance (MR) techniques to study digestion and highlights their potential for providing markers of digestive processes such as texture changes and nutrient breakdown. In vivo digestion research can be challenging due to practical constraints and biological complexity. Therefore, digestion is primarily studied using in vitro models. These would benefit from further in vivo validation. NMR is widely used to characterise food systems. MRI is a related technique that can be used to study both in vitro model systems and in vivo gastro-intestinal processes. MRI allows visualisation and quantification of gastric processes such as gastric emptying and coagulation. Both MRI and NMR scan sequences can be configured to be sensitive to different aspects of gastric or intestinal contents. For example, magnetisation transfer and chemical exchange saturation transfer can detect proton (1H) exchange between water and proteins. MRI techniques have the potential to provide molecular-level and quantitative information on in vivo gastric (protein) digestion. This requires careful validation in order to understand what these MR markers of digestion mean in a specific digestion context. Combined with other measures they can be used to validate and inform in vitro digestion models. This may bridge the gap between in vitro and in vivo digestion research and can aid the optimisation of food properties for different applications in health and disease.

show abstract

“…33 In two recent studies, participants received liquid meals at different viscosities and energy densities, and MRI was used to measure gastric content volumes every 10 min until 90 min after ingestion. 34,35 Results demonstrated higher gastric emptying half-time for a thick, high-calorie (500 kcal, 1 kcal/ml) meal, with approximately 80 min needed to reach 50% gastric emptying. Our pudding-like, semi-solid contrast meal had a higher caloric density (1.2 kcal/ml) and higher viscosity than a thick liquid, thus supporting the relatively slower gastric emptying rate demonstrated by our analysis compared to these prior studies.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, early gastric emptying rate has been shown to be determined by the meal volume but not its nutrient composition, using liquid meals 33 . In two recent studies, participants received liquid meals at different viscosities and energy densities, and MRI was used to measure gastric content volumes every 10 min until 90 min after ingestion 34,35 . Results demonstrated higher gastric emptying half‐time for a thick, high‐calorie (500 kcal, 1 kcal/ml) meal, with approximately 80 min needed to reach 50% gastric emptying.…”

Section: Discussionmentioning

confidence: 99%

Non‐uniform gastric wall kinematics revealed by 4D Cine magnetic resonance imaging in humans

Sclocco

Nguyen

Staley

et al. 2021

Neurogastroenterology Motil

View full text Add to dashboard Cite

Background Assessment of gastric function in humans has relied on modalities with varying degrees of invasiveness, which are usually limited to the evaluation of single aspects of gastric function, thus requiring patients to undergo a number of often invasive tests for a full clinical understanding. Therefore, the development of a non‐invasive tool able to concurrently assess multiple aspects of gastric function is highly desirable for both research and clinical assessments of gastrointestinal (GI) function. Recently, technological advances in magnetic resonance imaging (MRI) have provided new tools for dynamic (or “cine”) body imaging. Such approaches can be extended to GI applications. Methods In the present work, we propose a non‐invasive assessment of gastric function using a four‐dimensional (4D, volumetric cine imaging), free‐breathing MRI sequence with gadolinium‐free contrast enhancement achieved through a food‐based meal. In healthy subjects, we successfully estimated multiple parameters describing gastric emptying, motility, and peristalsis propagation patterns. Key Results Our data demonstrated non‐uniform kinematics of the gastric wall during peristaltic contraction, highlighting the importance of using volumetric data to derive motility measures. Conclusions & Inferences MRI has the potential of becoming an important clinical and gastric physiology research tool, providing objective parameters for the evaluation of impaired gastric function.

show abstract

Indirect vs direct assessment of gastric emptying: A randomized crossover trial comparing C‐isotope breath analysis and MRI

Cited by 16 publications

References 40 publications

Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit

Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit

Monitoring food digestion with magnetic resonance techniques

Non‐uniform gastric wall kinematics revealed by 4D Cine magnetic resonance imaging in humans

Contact Info

Product

Resources

About