Indirect traumatic optic neuropathy

Singman, Eric L.; Daphalapurkar, Nitin; White, Helen; Nguyen, Thao D.; Panghat, Lijo; Chang, Jessica R.; McCulley, Timothy J.

doi:10.1186/s40779-016-0069-2

Cited by 69 publications

(73 citation statements)

References 76 publications

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“…After 3 to 5 weeks, this distal optic nerve injury is seen as optic disc pallor. 9 In this study on veterans, we found that chronic mTBI patients had a very mild form of ITON. Mild visual symptoms (blurred vision, photophobia, floaters, flashes) occurred in 47% of these patients, whereas the others had none.…”

Section: Discussionmentioning

confidence: 63%

“…Data on the epidemiology and natural history of visual pathway trauma in the military are currently being collected from The Defense and Veterans Eye Injury and Vision Registry, a registry for traumatic optic neuropathy that collects longitudinal clinical data on active duty service members and veterans with traumatic visual dysfunction. 9 Not only are there no detailed published data about the natural history of ITON, 9 but it is uncertain which visual biomarkers are the most reliable to monitor the evolution of this visual injury. ITON in mild chronic TBI causes afferent visual dysfunction that has been previously unrecognized on routine clinical eye examination.…”

mentioning

confidence: 99%

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Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

Chan

Hills

Bakall

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To analyze the clinical presentation and optical coherence tomography (OCT) findings in indirect traumatic optic neuropathy (ITON) in veterans with chronic mild traumatic brain injury (mTBI). METHODS. This retrospective study is the first to describe the OCT pattern of subclinical to mild ITON in veterans with chronic mTBI. The thicknesses of the macular ganglion cell layer (mGCL), peripapillary retinal nerve fiber layer (pRNFL), and subfoveal choroidal layer were analyzed in young veterans who had mTBI of >6 months' duration and either blunt head injury or improvised explosive device (IED) concussions. RESULTS. Three major OCT findings were demonstrated: (1) temporal pRNFL thinning was associated with subclinical TON in the eyes of chronic mTBI patients compared with controls; within mTBI subjects, nasal mGCL thinning at the 3-mm modified Early Treatment Diabetic Retinopathy Study circle diameter distance from the fovea correlated with the corresponding temporal retinal nerve fiber layer thinning; (2) inner (1 mm) superior thinning was greater than that of the temporal mGCL in blunt head injury and could potentially distinguish it from IED concussive head trauma; and (3) subfoveal choroidal thinning was significantly worse in eyes of mTBI patients compared with those of controls. CONCLUSIONS. These OCT findings may contribute to the understanding of the spectrum of visual injuries resulting from head trauma.

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Section: Discussionmentioning

confidence: 63%

mentioning

confidence: 99%

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

Chan

Hills

Bakall

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…However, in questionable cases, VEP may provide confirmatory data. VEP may also have predictive value; patients with better responses on VEP may be more likely to regain some or all of their vision (Singman et al, 2016).…”

Section: Diagnosismentioning

confidence: 99%

“…Traumatic optic neuropathy occurs in approximately 0.5 to 5% of closed head injuries, and in 2.5% of patients with maxillofacial trauma and midface fractures (Chan, 2007). A recent study (Singman et al, 2016) asserts that in populations in England, for both adults and children, the overall incidence of traumatic optic neuropathy is approximately 1/million; notably, approximately 80% of the patients were males, and the majority of cases suffered relatively minor head injuries with neither orbital nor skull fracture. This suggests that indirect traumatic optic neuropathy may be more common than direct traumatic optic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Updating traumatic optic neuropathy

Fuentes¹,

Pelier²

2018

Int. J. Med. Med. Sci.

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Traumatic optic neuropathy (TON) is the affectation of the visual function, secondary to a damage caused by a direct or indirect traumatic mechanism over the optic nerve. It occurs in approximately 0.5 to 5% of closed head injuries, and in 2.5% of patients with maxillofacial trauma and mid-face fractures. The types of TON are direct, anterior indirect, posterior indirect, and chiasmal. This work aims to offer an updating in traumatic optic neuropathy. We made a search in international data bases such as PubMed, ClinicalTrial, Ebsco, Hinari and so on, and found 32 articles which were used in this review article. We used the following keywords: traumatic optic neuropathy, optic nerve, trauma, visual loss, visual disease. 70% of the articles correspond to the last five years. This review was redacted using Microsoft Office Word 2016 in a laptop Asus with Window 10 system. We made a compilation with diverse therapeutic options based principally in axonal regeneration developed by researchers during the last decade. The present review article provides an updating regarding potential strategies for axonal regeneration and optic nerve repair, focusing on the researches of many investigators around the world. Nowadays, therapeutic options have advanced in many fields, but still more researches must be done to find a definitive solution for traumatic optic neuropathy in a near future.

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“…Dysfunction of the retina, due to photoreceptor degeneration (as in Age-related macular degeneration[1-3] or Retinitis Pigmentosa[4,5]), optic nerve damage (due to Glaucoma or diabetic retinopathy), or enucleation of the eye (by combat ocular trauma[6] or traumatic optic neu-ropathy[7,8]), leads to a loss of signal transduction and/or transmission to the visual cortex. The electrical and optical stimulation methods employed in clinical trials of vision augmentation in blind patients with degenerated retinas [with intact optic nerves), involve retinal implants or external optical stimulation[9].…”

Section: Introductionmentioning

confidence: 99%

Bioluminescent Multi-Characteristic Opsin for monitoring visual cortical activity upon optical stimulation

Batabyal

Gajjeraman

Nagai

et al. 2018

Preprint

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Non-invasive detection of neural activity is important for the diagnosis of neurological diseases, evaluation of therapeutic outcomes, and collection of real-time feedback for stimulation based therapeutic approaches. In the case of vision loss, due to retinal degeneration, optic neuropathy, or enucleation of the eye, there is a need to map changes in visual cortical activity during disease progression and subsequent vision restoration by retinal, optic nerve or cortical stimulation. Existing technologies allow interrogation of neuronal circuits by both read and write activity, albeit with inherent limitations. Here, we present the development of bioluminescent multi-characteristic opsin (bMCO-11), which is comprised of a highly photosensitive ambient light-activatable domain and a Ca2+-sensitive bioluminescence reporter. The high quantum efficiency of bMCO-11 enables light activation and recording of cellular activity upon local as well as wide area optical stimulation. Furthermore, persistent Ca2+influx was achieved by bioluminescence based cyclic activation of the opsin-domain of bMCO-11 by transporting the ions only into bMCO expressing cells. This allowed us to continuously monitor visual cortical activity in wild type and retinal degenerated mice, without requiring any additional external excitation source.

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Indirect traumatic optic neuropathy

Cited by 69 publications

References 76 publications

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury

Updating traumatic optic neuropathy

Bioluminescent Multi-Characteristic Opsin for monitoring visual cortical activity upon optical stimulation

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