Indirect measurement of isovolumetric contraction time and tension period in normal subjects

Frank, Martin; Kinlaw, W B

doi:10.1016/0002-9149(62)90174-1

Cited by 47 publications

(11 citation statements)

References 17 publications

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“…In man, attention has been predominantly directed at the relationship between heart rate and the phases of systole both in groups and in individual subjects. Studies in single subjects have involved the use of exercise (10)(11)(12)(13)(14)(15)(16)(17), drugs (11,18,19), or other maneuvers (15,20,21), to alter heart rate. The resulting changes in the duration of both ejection and systole depend not only on heart rate, but also upon changes in stroke volume and in the inotropic background produced by the interventions.…”

Section: Discussionmentioning

confidence: 99%

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Pressure-flow studies in man. An evaluation of the duration of the phases of systole

Harley¹,

Starmer²,

Greenfield³

1969

J. Clin. Invest.

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A B S TR A C T This study was designed to assess the independent effects of stroke volume and heart rate on the phases of systole and other selected hemodynamic parameters. By means of the pressure gradient technique instantaneous blood pressure and flow were recorded in the ascending aorta at fixed ventricular rates in five patients with complete heart block and in four patients with atrio-ventricular dissociation induced by ventricular pacing. Because of the variable contribution of atrial systole to ventricular filling, a wide range of stroke volumes were observed at each heart rate. The results indicate that the duration of ejection bears a close direct linear relationship to stroke volume while heart rate has only a weak but independent relation. On the other hand, the duration of total systole is related chiefly to the heart rate but stroke volume exerts an important independent effect. In a given patient, both duration of ejection and pulse pressure reflect changes of stroke volume and the product of the duration of ejection and the pulse pressure shows a good correlation with the stroke volume. INTRODUCTIONPrevious studies in man of the relationships between heart rate, stroke volume, and other hemodynamic parameters such as the phases of systole, have been limited by the methodological difficulties encountered in measuring phasic blood flow. The recent development of the pres-

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Section: Discussionmentioning

confidence: 99%

“…It is clear that this period can only be regarded as an index of contractility in terms of the relation to stroke volume and heart rate for any particular beat. Thus, in the past, the explanation of the effect of exercise and drugs on preejection period has met with difficulty (11,12).…”

Section: Discussionmentioning

confidence: 99%

Pressure-flow studies in man. An evaluation of the duration of the phases of systole

Harley¹,

Starmer²,

Greenfield³

1969

J. Clin. Invest.

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“…These studies have shown that the duration of ejection varies directly with stroke volume, but that changes of stroke volume have little or no effect on the duration of total systole. Previous work in man has involved the use of drugs (23,24), exercise (25)(26)(27), or other maneuvers (28) in individual subjects, comparisons of patients with different diseases (29), or the statistical analysis of pooled single measurements from large numbers of individuals (27,28,30,31). In studies of this type the inotropic background will vary from one individual to another.…”

Section: Column 5)mentioning

confidence: 99%

Pressure-flow studies in man during atrial fibrillation

Greenfield¹,

Harley²,

Thompson³

et al. 1968

J. Clin. Invest.

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A B S T R A C T In 13 patients who had atrial fibrillation the ascending aortic pressure-flow relationships were measured by the pressure gradient technique. Both the pressure and flow curves were similar in contour to ones previously obtained by this method. From these recordings, relationships between the phases of systole, the ventricular filling time, and various derived parameters of pressure and flow such as the pulse pressure, stroke volume, peak flow, stroke work, and peak power were evaluated. For stroke volumes greater than 15 cm3 there was little change in the duration of systole in an individual patient. In each patient both the preejection period and the duration of ejection showed a good correlation with stroke volume, peak flow, stroke work, and peak power. When data from all patients were examined, the relationship between stroke volume and duration of ejection was found to be curvilinear and had an overall correlation of r = 0.91. There was marked variation from patient to patient in duration of both the preejection period and systole. Similar correlations between the phases of systole were noted with peak flow, peak power, and stroke work. A positive but mediocre correlation was found between the previous RR interval (an index of ventricular filling time) and the subsequent stroke volume. The correlation, in six patients, between two previous RR intervals and stroke volume was considerably better. The relationship between the pulse pressure and stroke volume was reasonably close except in one patient; however, the group correlation was poor due to differences between individuals.

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“…The LV ICT was noninvasively measured for the first time in 1962 using a phonocardiogram and carotid pulse. 23 Hirschfeld et al 24 demonstrated the value of LV ICT for assessing systolic LV performance in various heart diseases using M-mode echocardiography. Pulsed Doppler echocardiography could reveal the beginning and end of mitral and aortic flow more clearly than M-mode echocardiography or phonocardiography, and thus improved LV ICT measurements.…”

Section: Global Systolic Functionmentioning

confidence: 99%

Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension

et al. 2010

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Regional left ventricular (LV) systolic dysfunction has been identified in diastolic heart failure (DHF). However, the relationship between regional or global LV systolic function and heart failure symptoms in DHF has not been evaluated in detail. The present study evaluates such relationships in patients with systemic hypertension (HT) and DHF. We assessed LV systolic and diastolic function in 220 consecutive patients with systemic HT and in 30 normal individuals (Control) using Doppler echocardiography. Patients with HT were assigned to groups with DHF, asymptomatic diastolic dysfunction (ADD) and no diastolic dysfunction (Simple HT). Ejection fraction in DHF was significantly decreased (63 ± 8%) compared with the Control, Simple HT and ADD groups (67±5, 66±7 and 68±8%, respectively). Isovolumetric contraction time in DHF (70±30 msec) was significantly increased compared with those in the ADD, Simple HT and Control groups (31±17, 31±15 and 30±19 msec, respectively). Mitral annular systolic velocities were significantly decreased in the DHF and ADD groups (6.4 ± 1.5 and 7.2 ± 1.3 cm sec À1 , respectively) compared with those in the Simple HT and Control groups (8.5 ± 1.8 and 8.4 ± 3.0 cm sec À1 , respectively), and in the DHF group compared with the ADD group. LV global systolic dysfunction has a significant role in the development of heart failure symptoms associated with DHF in patients with systemic HT.

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Indirect measurement of isovolumetric contraction time and tension period in normal subjects

Cited by 47 publications

References 17 publications

Pressure-flow studies in man. An evaluation of the duration of the phases of systole

Pressure-flow studies in man. An evaluation of the duration of the phases of systole

Pressure-flow studies in man during atrial fibrillation

Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension

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