Indirect cytocompatibility of a low‐concentration hydrogen peroxide bleaching gel to odontoblast‐like cells

Abstract

The 17.5% H2O2 applied to tooth specimens for 5 min caused no alteration in the odontoblast-like cells. When this gel was applied for 45 or 15 min, a slight cytotoxicity, associated with alterations in phenotypic markers, was observed. However, cells were able to recover their functions up to 21 days post-bleaching.

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

“…, Soares et al . ). Lower H 2 O 2 concentrations strongly induced the expression of proteins associated with the mineralization process, whereas these proteins were adjusted according to the concentration of H 2 O 2 .…”

In vivo analysis of the presence of heme oxygenase‐1, transcription factor Jun‐D and CD90+/CD73+/CD105+/CD45‐ cells in the pulp of bleached teeth

“…, , Soares et al . ). Changes in the pulp tissue occur after bleaching, such as intense cell proliferation (Benetti et al .…”

Effectiveness of 6% hydrogen peroxide concentration for tooth bleaching—A double-blind, randomized clinical trial

“…10 Soares et al recently reported on low-concentration (17.5%) and short-duration applications and found significantly reduced cellular damage under in vitro conditions. [12][13][14] There is interest in RCTs to assess compounds with lower concentration that would comply with standards such as those of the European Community. The objective of this work is to show the effectiveness of a bleaching gel (6%) catalyzed by titanium dioxide nanoparticles and activated by hybrid light.…”