Indirect comparisons of competing interventions

Abstract

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Preventive Pharmacologic Treatments for Episodic Migraine in Adults

“…[60][61][62][63][64] First, we used adjusted indirect frequentist comparisons for individual drugs compared with placebo. 62 This analysis provided pairwise triangular comparisons for drugs compared with placebo rather than network meta-analysis. Second, to address the problems with inevitable differences across studies, we used mixed (or multiple) treatment comparison (MTCs) Bayesian network meta-analysis.…”

“…Second, to address the problems with inevitable differences across studies, we used mixed (or multiple) treatment comparison (MTCs) Bayesian network meta-analysis. [62][63][64] We calculated Bayesian odds ratios 43,51 with 2.5 to 97.5 % credible intervals and Bayesian network random effects metaanalysis assuming heterogeneous variances across treatments (online Appendix Table 3). 65 We synthesized evidence from drug classes in network meta-analysis when individual drugs from the same class demonstrated no significant differences in outcomes.…”

Rivaroxaban vs Dabigatran for Thromboprophylaxis After Joint-replacement Surgery: Exploratory Indirect Comparison Based on Meta-Analysis of Pivotal Clinical Trials

“…The treatment effect of A vs B (T AB ) is derived from treatment effects of A vs C (T AC ) and B vs C (T BC ) and the procedure is termed adjusted indirect comparison (16,17).…”

Comparison of mHealth and Face-to-Face Interventions for Smoking Cessation Among People Living With HIV: Meta-Analysis (Preprint)

“…We adopted an adjusted indirect comparison meta-analysis [16][17][18][19] , a logical extension of standard meta-analysis to infer relative effectiveness of mHealth delivered versus face-to-face interventions when the direct "head-to-head" evidence is lacking, i.e. not directly addressed within any of the included trials.…”

“…Average age of the study population was 45 years (range: 42 to 50) and women comprised about 37% (range: 8% to 100%). Smoking cessation strategies were administered face-to-face in seven studies, [14][15][16][17][18]20,21 and sustained smoking abstinence estimates were reported in four studies. 14,[21][22][23] The intensity and maximum follow-up period ranged from 4 weeks to as much 52 weeks.…”