Indigo Pulverata Levis (Chung-Dae, Persicaria tinctoria) Alleviates Atopic Dermatitis-like Inflammatory Responses In Vivo and In Vitro

Min, Ga-Yul; Kim, Ji Hye; Kim, Tae-In; Cho, Won‐Kyung; Yang, Ju-Hye; Ma, Jin-Yeul

doi:10.3390/ijms23010553

Cited by 10 publications

(14 citation statements)

References 57 publications

(60 reference statements)

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“…As AD pathogenesis shares common features with allergic diseases, such as pro-inflammatory immune responses ( Akdis et al ., 2006 ; Bantz et al ., 2014 ), various anti-inflammatory immune regulators from the natural extracts of medicinal plants have shown therapeutic potentials in AD ( Ku et al ., 2018 ; Song et al ., 2019 ; Bai et al ., 2020 ). Notably, from the previous studies, we understand that a common mode of action of natural products exists, i.e., by suppression of MAPKs and NF-κB ( Chen et al ., 2020 ; Min et al ., 2022 ; Zhang et al ., 2022 ). Thus, by using NJK14047, a potent and specific p38 MAPK inhibitor, for the first time, we recognized the importance of p38 MAPK inhibitors to develop novel anti-AD drugs because p38 MAPK inhibition distinctly leads to the suppression of the immune responses of AD.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported the effectiveness of traditional Chinese medicines and their active components in treating AD ( Chen et al ., 2020 ; Min et al ., 2022 ; Zhang et al ., 2022 ). Interestingly, suppression of AD by traditional Chinese medicines has been reported to be mediated through the inhibition of mitogen-activated protein kinases (MAPKs), such as, ERK, JNK, and p38 MAPK, and NF-κB components, such as p65 ( Chen et al ., 2020 ; Min et al ., 2022 ; Zhang et al ., 2022 ). In fact, overexpression of MAPK mRNA in the skin tissue was observed in the AD group ( Chen et al ., 2020 ; Min et al ., 2022 ; Zhang et al ., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, suppression of AD by traditional Chinese medicines has been reported to be mediated through the inhibition of mitogen-activated protein kinases (MAPKs), such as, ERK, JNK, and p38 MAPK, and NF-κB components, such as p65 ( Chen et al ., 2020 ; Min et al ., 2022 ; Zhang et al ., 2022 ). In fact, overexpression of MAPK mRNA in the skin tissue was observed in the AD group ( Chen et al ., 2020 ; Min et al ., 2022 ; Zhang et al ., 2022 ). However, the role of each MAPK in AD pathogenesis has not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

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p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

Lee

Son

Kim

et al. 2022

Biomol Ther (Seoul)

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Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy. Although overexpression of MAPK mRNA in the skin tissue has been shown in the AD model, the roles of each MAPK in AD pathogenesis have rarely been studied. This study examined the effect of NJK14047, an inhibitor of p38 MAPKs, on AD-like skin lesions induced in BALB/c mice by sensitization and challenges with 1-chloro-2,4-dinitrobenzene (CDNB) on dorsal skin and ears, respectively. After induction of AD, NJK14047 (2.5 mg/kg) or dexamethasone (10 mg/kg) was administrated for 3 weeks via intraperitoneal injection. Following its administration, NJK14047 suppressed CDNB-induced AD-like symptoms such as skin hypertrophy and suppressed mast cell infiltration into the skin lesions. It also reduced CDNB-induced increase in TH2 cytokine (IL-13) and TH1 cytokines (interferon-γ and IL-12A) levels but did not decrease serum IgE level. Furthermore, NJK14047 blocked CDNB-induced lymph node enlargement. These results suggest that NJK14047, a p38 MAPK inhibitor, might be an optimal therapeutic option with unique modes of action for AD treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

Lee

Son

Kim

et al. 2022

Biomol Ther (Seoul)

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“…Patients with atopic dermatitis, the sensitivity to gentamicin was 99.7%. Fusidic acid is reported to have advantages over other anti-bacterials (Min et al, 2022) There are several combinations of antibiotics and topical corticosteroids as combination therapy in patients with atopic dermatitis. According to studies, the best combination is a topical corticosteroid with fusidic acid.…”

Section: Discussionmentioning

confidence: 99%

Characteristic of Atopic Dermatitis in Policlinic Dermatology Siloam Hospital Bali

Rahayu¹

2022

IJRP

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Backgrounds: Atopic dermatitis (AD) is a type of dermatitis (eczema) that occurs due to skin inflammation. This condition can be accompanied by red, dry, and cracked skin. Inflammation usually lasts a long time, even years. The epidemiology of AD worldwide ranges from 5 20% in children and 1 3% in adults. Morbidity varies greatly in each country due to the influence of the environment as a risk factor. The prevalence of atopic dermatitis in developed countries has been reported to have decreased, while in developing countries, it is increasing. Aim: knowing the characteristics of AD at Siloam Hospital Bali in the period January 1, 2021to December 31, 2021 Method: This study used a descriptive method with a retrospective cross-sectional approach. The sample used was 60 taken from the total population of DA January 1, 2021to December 31, 2021 based on secondary data from medical records in the form of patient age, gender, location of skin disorders, history of atopy, and therapy and then processed by descriptive statistics. Results: From the results of this study, it is known that the age group is 12-18 years old 24 (40%), female sex 42 (70%), flexor location 20 (33.3%), with the most atopy history 35 (58.3%) and topical corticosteroid therapy 45 (75%). Conclusion: AD In Siloam hospital having characteristic data the most of aged 12-18 years and female sex. The location of most lesions is in the flexor area. The treatment given depends on the age, phase of the disease, and the most of topical corticosteroids choice to treatment.

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“…2), mainly as its sulfonic salt, indigo carmine ( Figure 1 ). Additionally, further research has emerged for its application in the development of eco-friendly organic semiconductors [ 5 , 6 ], and has demonstrated its positive effect in traditional Chinese medicine to treat psoriasis and other inflammatory diseases [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of New Phenylacetone Monooxygenase Variants for the Development of Substituted Indigoids through Biocatalysis

Núñez-Navarro

Muñoz

Castillo

et al. 2022

IJMS

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Indigoids are natural pigments obtained from plants by ancient cultures. Romans used them mainly as dyes, whereas Asian cultures applied these compounds as treatment agents for several diseases. In the modern era, the chemical industry has made it possible to identify and develop synthetic routes to obtain them from petroleum derivatives. However, these processes require high temperatures and pressures and large amounts of solvents, acids, and alkali agents. Thus, enzyme engineering and the development of bacteria as whole-cell biocatalysts emerges as a promising green alternative to avoid the use of these hazardous materials and consequently prevent toxic waste generation. In this research, we obtained two novel variants of phenylacetone monooxygenase (PAMO) by iterative saturation mutagenesis. Heterologous expression of these two enzymes, called PAMOHPCD and PAMOHPED, in E. coli was serendipitously found to produce indigoids. These interesting results encourage us to characterize the thermal stability and enzyme kinetics of these new variants and to evaluate indigo and indirubin production in a whole-cell system by HPLC. The highest yields were obtained with PAMOHPCD supplemented with L-tryptophan, producing ~3000 mg/L indigo and ~130.0 mg/L indirubin. Additionally, both enzymes could oxidize and produce several indigo derivatives from substituted indoles, with PAMOHPCD being able to produce the well-known Tyrian purple. Our results indicate that the PAMO variants described herein have potential application in the textile, pharmaceutics, and semiconductors industries, prompting the use of environmentally friendly strategies to obtain a diverse variety of indigoids.

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Indigo Pulverata Levis (Chung-Dae, Persicaria tinctoria) Alleviates Atopic Dermatitis-like Inflammatory Responses In Vivo and In Vitro

Cited by 10 publications

References 57 publications

p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

Characteristic of Atopic Dermatitis in Policlinic Dermatology Siloam Hospital Bali

Discovery of New Phenylacetone Monooxygenase Variants for the Development of Substituted Indigoids through Biocatalysis

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