Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions

Lin, Yin-Ku; Chen, Hsiao‐Wen; Leu, Yann‐Lii; Yang, Yueh-Lung; Fang, Yiqun; Hwang, Tsong‐Long

doi:10.1016/j.jep.2012.11.044

Cited by 37 publications

(19 citation statements)

References 30 publications

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“…It has been shown that PKCδ altered the expression of tight junction proteins, including CLDN1, in pancreas, liver, skin and melanoma cell lines [19][20][21][22]. Furthermore, previous studies have shown that TNF-α increases PKC activity in A549 cells [23][24][25].…”

Section: Tnf-α Induced Cldn1 Expression May Be Mediated Through Pkcδmentioning

confidence: 96%

PKCδ–iPLA2–PGE2–PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells

Iitaka

Moodley

Shimizu

et al. 2015

Cellular Signalling

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Section: Tnf-α Induced Cldn1 Expression May Be Mediated Through Pkcδmentioning

confidence: 96%

PKCδ–iPLA2–PGE2–PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells

Iitaka

Moodley

Shimizu

et al. 2015

Cellular Signalling

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“…It contains multiple ingredients including indirubin, indigo, and tryptanthrin [2]. IND has traditionally been used as an anti-inflammatory agent to treat a wide range of pathological conditions such as skin rash, dermatitis, venom detoxification, and upper airway inflammation [2,3,4]. IND is applied topically to the skin to treat psoriasis, and its efficacy has been demonstrated in several clinical reports [5,6].…”

Section: Introductionmentioning

confidence: 99%

Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora

Adachi

Hoshi²,

Inoue³

et al. 2017

Int Arch Allergy Immunol

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Background: Indigo naturalis (IND) is an herbal medicine that has been used as an anti-inflammatory agent to treat diseases including dermatitis and inflammatory bowel disease in China. However, the mechanism by which IND exerts its immunomodulatory effect is not well understood. Methods: A murine model of dermatitis and inflammatory bowel disease, both induced by oxazolone (OXA), was treated with IND. The severity of dermatitis was evaluated based on ear thickness measurements and histological scoring. The severity of colitis was evaluated by measuring body weight, histological scoring, and endoscopic scoring. The expression of inflammatory cytokines in ear and colon tissue was evaluated using real-time PCR. 16S rRNA DNA sequencing of feces from OXA-induced colitis mice was performed before and after IND treatment. The effects of IND on OXA-induced colitis were also evaluated after depleting the gut flora with antibiotics to test whether alteration of the gut flora by IND influenced the course of intestinal inflammation in this model. Results: IND treatment ameliorated OXA dermatitis with a reduction in IL-4 and eosinophil recruitment. However, OXA colitis was significantly aggravated in spite of a reduction in intestinal IL-13, a pivotal cytokine in the induction of the colitis. It was found that IND dramatically altered the gut flora and IND no longer exacerbated colitis when colitis was induced after gut flora depletion. Conclusions: Our data suggest that IND could modify the inflammatory immune response in multiple ways, either directly (i.e., modification of the allergic immune cell activity) or indirectly (i.e., alteration of commensal compositions).

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“…In psoriatic lesions indigo naturalis has been shown to upregulate claudin-1 expression and restore tight junction function; synergistic effect was reported for indirubin, inigo and tryptanthrin (Lin et al, 2013). Clinical studies by Lin and his group (2007Lin and his group ( , 2008Lin and his group ( , 2011 on topical formulations of indigo naturalis, including oils and ointments, report efficacy in plaque psoriasis, nail psoriasis, also recalcitrant forms, in both adult and pediatric patients.…”

mentioning

confidence: 98%

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

Boca

Tătaru

Pincelli

et al. 2014

Not Bot Hort Agrobot Cluj

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Psoriasis is a chronic inflammatory skin disease, with an important impact on the patient's quality of life. Its incidence and prevalence are continuously increasing. The complex ethiopathology of this disorder is only partially known; there is a clear genetic predisposition, which associates a number of environmental triggering factors such as an unbalanced diet and lifestyle. The conventional therapeutic options are not always satisfactory in terms of efficiency and safety, therefore, complementary and alternative medicine approaches are frequently chosen by patients, mostly as self-medication. This review, based on recent literature flow data, outlines the pharmacological benefits of herbal formulations with antipsoriatic activity. It also reveals the molecules responsible for their effects, as well as their interference with the metabolic and immunopathogenic mechanisms of this disease. An important number of plants have been proved to act as antipsoriatic agents, many botanical-based preparations containing keyphytochemical molecules (belonging mainly to phenolics, triterpenoids and phytosterols or unsaturated fatty acids, as mentioned in specific phyto-pharmaceutical databases). Specific mechanisms of action, which can explain their activity (such as lipoxygenase inhibition, antioxidant, anti-inflammatory, anti prostaglandin), were recently described. Only some of these formulations have been actively tested in vitro or in vivo. Most publications in the field agree on the need for more in vitro and in vivo studies, especially clinical assessment on patients with Psoriasis vulgaris. These would provide more accurate data on the efficacy and safety of such herbal formulations for this disease.

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Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions

Cited by 37 publications

References 30 publications

PKCδ–iPLA2–PGE2–PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells

PKCδ–iPLA2–PGE2–PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells

Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

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