Indigenous Traditional Medicine: Plants for the Treatment of Diarrhea

Brandelli, Clara Lia Costa; Giordani, Raquel Brandt; Macêdo, Alexandre José; Carli, Geraldo Attílio De; Tasca, Tiana

doi:10.1007/978-3-642-19382-8_1

Cited by 5 publications

(2 citation statements)

References 82 publications

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“…The rescue ethnopharmacology of historical uses of plants is recognized as valuable for bioprospection, since they afford the rationale for selection and research of medicinal plants [15]. This study describes the first report on the antiprotozoal activity of Verbena sp.…”

Section: Resultsmentioning

confidence: 99%

“…Since ancient times, people use plants to treat common infectious diseases, and some of these traditional medicines are still integrated as part of the cure of diverse pathologies [13]. In addition, the search based on ethnopharmacological information rescues the immense empirical knowledge of plants utilization [14, 15]. In this context, regarding natural environment and vast wealth of genetic resources, Brazil is a country of great interest to ethnopharmacology [16].…”

Section: Introductionmentioning

confidence: 99%

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Remarkable Anti-Trichomonas vaginalisActivity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil

Brandelli

Vieira

Macêdo

et al. 2013

BioMed Research International

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Trichomonas vaginalis, a flagellate protozoan, is the causative agent of trichomonosis, the most common nonviral sexually transmitted disease worldwide. Taking into account the increased prevalence of metronidazole-resistant isolates, alternative drugs are essential for the successful treatment. Natural products are the source of most new drugs, and popular wisdom about the use of medicinal plants is a powerful tool in this search. In this study, the activity of 10 medicinal plants extensively used in daily life by Mbyá-Guarani indigenous group was evaluated against seven different T. vaginalis isolates. Among the aqueous extracts tested, Verbena sp. (Guachu ka'a in Mbyá-Guarani language) and Campomanesia xanthocarpa (Guavira in Mbyá-Guarani language) showed the highest activity against T. vaginalis with MIC value of 4.0 mg/mL reaching 100% of efficacy against the parasite. The kinetic growth assays showed that the extracts promoted complete growth abolishment after 4 h of incubation. In addition, the extracts tested did not promote a significant hemolytic activity against human erythrocytes. Our results show for the first time the potential activity of Verbena sp. and C. xanthocarpa against T. vaginalis. In addition, this study demonstrates that indigenous knowledge is an important source of new prototype antiprotozoal agents.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remarkable Anti-Trichomonas vaginalisActivity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil

Brandelli

Vieira

Macêdo

et al. 2013

BioMed Research International

Self Cite

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Do Nanomosquitocides Impact Predation of Mesocyclops edax Copepods Against Anopheles stephensi Larvae?

Chandramohan

Murugan

Kovendan

et al. 2016

Nanoparticles in the Fight Against Parasites

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One pot synthesis of silver nanocrystals using the seaweed Gracilaria edulis: biophysical characterization and potential against the filariasis vector Culex quinquefasciatus and the midge Chironomus circumdatus

Madhiyazhagan¹,

Murugan

Kumar

et al. 2016

J Appl Phycol

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Mosquitoes (Diptera: Culicidae) represent a deadly threat for millions of humans and animals worldwide. Seaweeds are an important resource for marine biotechnology and are currently investigated as sources of reducing and capping agents for the nanosynthesis of mosquitocides. Culex quinquefasciatus is a major vector of lymphatic filariasis, while chironomid midges (Diptera: Chironomidae) elicit allergic reactions. In this research, silver nanoparticles (AgNP) were biosynthesized using a cheap aqueous extract of Gracilaria edulis as reducing and stabilizing agent. The formation of AgNP was confirmed by UV–Vis spectrophotometry. AgNP were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and energy dispersive X-ray analysis. AgNP were mostly spherical and cubic in shape, crystalline in nature. Gracilaria edulis-synthesized AgNP showed excellent ovicidal, larvicidal, pupicidal, and ovideterrent toxicity against Cx. quinquefasciatus and Chironomus circumdatus. Larvicidal LC50 ranged from 17 to 29 ppm. AgNP of 30 ppm led to 100 % mortality in treated eggs. Doses higher than 10 ppm lead to oviposition deterrence rates higher than 75 % (Oviposition Activity Index lower than −0.59). In the field, a single application of AgNP (10 × LC50) led to elimination of larval populations of Cx. quinquefasciatus and Ch. circumdatus within 72 h. Overall, G. edulis-synthesized AgNP may be potential candidates to develop eco-friendly control tools against Diptera of medical and veterinary importance

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Indigenous Traditional Medicine: Plants for the Treatment of Diarrhea

Cited by 5 publications

References 82 publications

Remarkable Anti-Trichomonas vaginalisActivity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil

Remarkable Anti-Trichomonas vaginalisActivity of Plants Traditionally Used by the Mbyá-Guarani Indigenous Group in Brazil

Do Nanomosquitocides Impact Predation of Mesocyclops edax Copepods Against Anopheles stephensi Larvae?

One pot synthesis of silver nanocrystals using the seaweed Gracilaria edulis: biophysical characterization and potential against the filariasis vector Culex quinquefasciatus and the midge Chironomus circumdatus

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