Many world issues are faced and then become challenges of the 21st century. This study aims to define these challenges and how to overcome them as alternative solutions in architecture, with the context of sustainable architecture from an Islamic perspective. The methods used are literature review and logical argumentation. The results show that the challenges of the 21st century in the context of sustainable architecture include fundamental issues, namely nature conservation, related to humanity and technology as specific objectives, and several other objectives of the Sustainable Development Goals. Challenges can be faced by integrating the handling of each aspect, focusing on humans. In the view of Islam, integrated solutions are carried out within the spirituality framework, where humans act as caliphs. Through education, a means of accelerating human knowledge is obtained; through a spiritual approach, humans will think twice about destroying the universe and its contents.