Indices of the metabolism of connective tissue biopolymers in the amniotic fluid of pregnant womenwith placental insufficiency in preeclampsia

Tetelyutina, F. K.; Sakhabutdinova, E P; Logutko, N. N.

doi:10.17116/rosakush20191902127

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Гипоксия оказывает влияние на морфогенез эпителия, стимулирует его ги перплазию, а также клеточную пролифера цию и деление сосудов легких. Гипоксия стимулирует пролиферацию и секрецию ангиогенных медиаторов в плаценте, таких как сосудистый эндотелиальный фактор роста (vascular endothelial growth factor -VEGF) и интерлейкин 8, усугубляет реакции на аллерген, что приводит к увеличению воспаления и повышенному уровню транс формирующего фактора роста β (transfor ming growth factor β -TGF β), снижает трансэпителиальный перенос Na+, а также способствует повышенному продуцирова нию слизи в эпителиальных клетках дыха тельных путей плода и новорожденного [8,9]. Сочетание этих факторов в конечном счете приводит к развитию внутриутробной инфекции и сепсиса.…”

Section: Introductionunclassified

Analysis of congenital pneumonia incidence in newborns from high-risk mothers

Tezikov

Липатов²,

Zagrebelnaya³

et al. 2023

Perm Medical Journal

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Objective. To detect the incidence of congenital pneumonia in newborns from mothers with placental insufficiency in combination with premature amniotic fluid discharge Materials and methods. A retrospective analysis of 57 stories of newborn infants and their mothers was carried out. The newborns were divided into 3 groups: group 1 37 newborns from mothers with placental insufficiency and premature amniotic fluid discharge, group 2 9 infants from mothers with premature amniotic fluid discharge, group 3 11 infants born from mothers with placental insufficiency. The obstetric and gynecological history, the presence of extragenital pathology, the peculiarities of the course of pregnancy and childbirth, and the outcomes for newborns were analyzed. Results. Congenital pneumonia was more common in newborns from mothers with placental insufficiency and premature amniotic fluid discharge. In newborn infants of the first group, severe asphyxia occurred more often, being a risk factor. At the same time, the identification of markers of the systemic inflammatory reaction did not always reflect the presence of infectious-inflammatory pathology in newborns. In addition, in the presence of inflammation of the fetal part of placenta, in a large number of newborns pathological microflora is detected during microbiological examination. Conclusions. As a result of the study, the role of maternal pathology on the development of intrauterine infection and implementation of infection in the early neonatal period was revealed. The obtained data justify the need for pregravid preparation and prevention of perinatal complications in women with placental insufficiency.

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Section: Introductionunclassified

Analysis of congenital pneumonia incidence in newborns from high-risk mothers

Tezikov

Липатов²,

Zagrebelnaya³

et al. 2023

Perm Medical Journal

View full text Add to dashboard Cite

show abstract

Disturbances of Cardiovascular Activity and Endothelial Function in Pregnant Women with Undifferentiated Connective Tissue Dysplasia and their Correction by Carnitine-arginine Complex Inclusion in the Protocol Treatment Program

Добрянська¹

2021

Lʹviv. klin. visn.

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Context. Undifferentiated connective tissue dysplasia (UCTD) has negative impact on myocardial contractility and endothelial microvascular dysfunction and their frequent combination with cardiac arrhythmias suggests an unfavorable course of pregnancy and childbirth due to the formation of uteroplacental dysfunction. Objective. To reduce the incidence of obstetric complications associated with cardiovascular disorders in women with UCTD by including carnitine-arginine complex in the treatment program. Materials and methods. 58 pregnant women with diagnosed signs of UCTD, including mitral valve prolaps (MVP) with and without frequent extrasystoles, and 14 pregnant women of control group were examined. Metabolic support with of 4.2 g of L-arginine and 2.0 g of L-carnitine in the form of a solution for intravenous infusion once a day for 5 days were used for prenatal care of pregnant women with UCTD and prevention of obstetric complications in the experimental group. Results. There are violations of morpho-functional parameters of the heart with the development of moderate systolic-diastolic myocardial dysfunction and endothelial microvascular dysfunction in the initial state of pregnant women with MVP and extrasystolic arrhythmia against the background of UCTD. They were significantly more often diagnosed with miscarriage, late preeclampsia, placental dysfunction, birth defects, birth trauma, postpartum hemorrhage, etc. Echostructural abnormalities of the heart acted as predictors of arrhythmias, the presence of which was associated with more pronounced disorders of intracardiac hemodynamics. The results of a comprehensive study of the clinical and functional status of pregnant women with phenotypic signs of UCTD, MVP and extrasystolic arrhythmia suggest that in most cases they occur with moderate heart remodeling and significant endothelial dysfunction of the microvascular circulation, that was accompanied by significant deterioration of the obstetric situation. The use of standard medication by pregnant women did not significantly restore the incidence of arrhythmias, inotropic capacity of the myocardium and endothelial function of microvessels. Supraventricular and ventricular arrhythmias remained resistant to standard treatment, which justified the use of additional antiarrhythmic drugs. At the same time, there was a significant reduction in the incidence of arrhythmias in the group of patients with MVP and frequent ventricular or mixed extrasystoles – by 90.6 and 77.8 % respectively under the influence of complex drug treatment with the inclusion of L-arginine and L-carnitine. In the group of pregnant women with supraventricular arrhythmias, the antiarrhythmic effect was observed in only 37.5 % of patients, which justified the additional use of nebivolol hydrochloride at a dose of 2.5 mg/day. At the same time, such a comprehensive treatment in pregnant women with MVP and arrhythmia on the background of UCTD contributed to the restoration of the studied indicators of endothelial function of microvessels. Conclusions. In pregnant women with MVP and extrasystolic arrhythmia against the background of UCTD in the initial state there are violations of morpho-functional parameters of the heart with the development of moderate systolic-diastolic myocardial dysfunction and endothelial microvascular dysfunction, which are triggers of complicated pregnancy and childbirth. The inclusion of L-arginine and L-carnitine led to a significant improvement in the parameters of central cardiohemodynamics and restoration of endothelial function of microvessels and accompanied by a significant reduction of the incidence of extrasystolic arrhythmia and pregnancy complications.

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Indices of the metabolism of connective tissue biopolymers in the amniotic fluid of pregnant womenwith placental insufficiency in preeclampsia

Cited by 2 publications

References 10 publications

Analysis of congenital pneumonia incidence in newborns from high-risk mothers

Analysis of congenital pneumonia incidence in newborns from high-risk mothers

Disturbances of Cardiovascular Activity and Endothelial Function in Pregnant Women with Undifferentiated Connective Tissue Dysplasia and their Correction by Carnitine-arginine Complex Inclusion in the Protocol Treatment Program

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