Indices of protein status as predictors of complications in low risk surgical patients of hernias and lithiasis

Lb, Zago; Dupraz, Hernan; Weisstaub, A.; Godoy, María Fernanda; Slobodianik, Nora; Gasali, Fernando; C, Dirube; Torino, Francisco; Me, Río

doi:10.1016/s0271-5317(99)00153-0

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Otras proteínas plasmáticas se afectan por la inflamación y la función hepática, dependiendo también de las funciones específicas en el metabolismo de otros nutrientes. En la Tabla 3 se resumen las determinaciones más utilizadas en la clínica, sus limitaciones y los indicadores urinarios estudiados por su sencillez, pero poco utilizados por la complicación práctica en la recolección de la muestra (20,(25)(26)(27)(28) .…”

Section: Aporte Energético Y Proteicounclassified

“…Un pequeño porcentaje de Cu se absorbe en el estómago solubilizado por la acidez, pero la mayor parte se absorbe a lo largo del intestino delgado, mediante un **Segunda orina de la mañana con ayuno de líquidos y sólidos. Modificado de (20,(25)(26)(27)(28) mecanismo pasivo (paracelular) no saturable y otro activo, transcelular y saturable, que depende de la síntesis de metalotioneína (MT). El Cu se absorbe como catión divalente y existe un mecanismo competitivo con otros cationes divalentes, fundamentalmente el Zn o el Fe.…”

Section: Cobreunclassified

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Abordaje de las deficiencias nutricionales pre y poscirugía bariátrica: una revisión narrativa

Menéndez

Montemerlo

Martín

2022

rncm

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La obesidad es una enfermedad metabólica, crónica y multifactorial que requiere tratamiento escalonado y multidisciplinario. La cirugía bariátrica (CB) constituye una opción de tratamiento para pacientes con obesidad severa o enfermedades metabólicas asociadas. La tasa de complicaciones agudas poscirugía es baja debido a la incorporación de las técnicas miniinvasivas y al abordaje interdisciplinario.

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Section: Aporte Energético Y Proteicounclassified

Section: Cobreunclassified

Abordaje de las deficiencias nutricionales pre y poscirugía bariátrica: una revisión narrativa

Menéndez

Montemerlo

Martín

2022

rncm

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“…Devakonda et al [88] reported that surgery patients with low preoperative TTR values had significantly longer hospital duration of stay and longer intensive care unit duration of stay. Moreover, low concentrations of transthyretin were associated with higher rates of infectious complications, mortality and other surgical complications [95,96].…”

Section: Prognostic Indicatormentioning

confidence: 99%

Transthyretin in the Evaluation of Health and Disease in Human and Veterinary Medicine

Tóthová¹,

Nagy²

2018

Pathophysiology - Altered Physiological States

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Transthyretin (also known as prealbumin) is an important transport protein, which plays an essential role in the binding of thyroid hormones and retinol with varying affinities in mammalian, as well as avian species. The determination of transthyretin concentrations may be used as a diagnostic tool for some disease conditions in humans, but is more often used as a nutritional marker to assess protein-calorie malnutrition and as prognostic indicator in critically ill patients. Transthyretin has shorter half-life (2-3 days) than that of albumin and belongs to negative acute phase proteins. This may complicate the use of transthyretin as a nutritional marker and the interpretation of results in the diagnosis of diseases. Although some studies have been carried out to determine the usefulness of transthyretin in selected disease conditions and disorders also in animals, it is a relatively rarely used parameter to evaluate health state and illness in veterinary medicine. The usefulness of transthyretin in the diagnosis of diseases and evaluation of nutritional status in humans and animals are reviewed in this article, including the laboratory assays available to measure its concentrations and the possible clinical application of the results, as well as its usefulness as a prognostic indicator in some disease conditions.

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“…Transthyretin (TTR) has been reported as a predictor for worse outcomes in surgical [1][2][3][4][5][6], burn [7,8], and critically ill medical [9] patients. Furthermore, TTR has been shown to be a useful marker assessing malnutrition [10,11] and for tracking the adequacy of in-hospital nutritional support [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Although an association between TTR levels and outcomes has been described in previous studies [1–9], TTR has not been prospectively assessed as a maker for outcomes in critically ill trauma patients so far. Furthermore, the impact of TTR values over time on outcomes has not yet been prospectively investigated in this patient population.…”

Section: Introductionmentioning

confidence: 99%

Transthyretin at Admission and Over Time as a Marker for Clinical Outcomes in Critically Ill Trauma Patients: A Prospective Single‐Center Study

et al. 2019

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Background Transthyretin (TTR) has been described as a predictor for outcomes in medical and surgical patients. However, the association of TTR on admission and over time on outcomes has not yet been prospectively assessed in trauma patients. Methods This is a prospective observational study including trauma patients admitted to the intensive care unit (ICU) of a large Level I trauma center 05/2014-05/2015. TTR levels at ICU admission and all subsequent values over time were recorded. Patients were observed for 28 days or until hospital discharge. The association of outcomes and TTR levels at admission and over time was assessed using multivariable regression and generalized estimating equation (GEE) analysis, respectively. Results A total of 237 patients with TTR obtained at admission were included, 69 of whom had repeated TTR measurements. Median age was 40.0 years and median ISS 16.0; 83.1% were male. Below-normal TTR levels at admission (41.8%) were independently associated with higher in-hospital mortality (p = 0.042), more infectious complications (p = 0.032), longer total hospital length of stay (LOS) (p = 0.013), and ICU LOS (p = 0.041). Higher TTR levels over time were independently associated with lower in-hospital mortality (p = 0.015), fewer infections complications (p = 0.028), shorter total hospital and ICU LOS (both p \ 0.001), and fewer ventilator days (0.004). Conclusions In critically ill trauma patients, below-normal TTR levels at admission were independently associated with worse outcomes and higher TTR levels over time with better outcomes, including lower in-hospital mortality, less infectious complications, shorter total hospital and ICU LOS, and fewer ventilator days. Based on these results, TTR may be considered as a prognostic marker in this patient population.

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Indices of protein status as predictors of complications in low risk surgical patients of hernias and lithiasis

Cited by 6 publications

References 12 publications

Abordaje de las deficiencias nutricionales pre y poscirugía bariátrica: una revisión narrativa

Abordaje de las deficiencias nutricionales pre y poscirugía bariátrica: una revisión narrativa

Transthyretin in the Evaluation of Health and Disease in Human and Veterinary Medicine

Transthyretin at Admission and Over Time as a Marker for Clinical Outcomes in Critically Ill Trauma Patients: A Prospective Single‐Center Study

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