Indices of Oxidative Stress in Eutopic and Ectopic Endometria of Women with Endometriosis

Öner-İyidoğan, Yıldız; Koçak, Hikmet; Gürdöl, Figen; Korkmaz, Düzgün; Buyru, Faruk

doi:10.1159/000076691

Cited by 41 publications

(43 citation statements)

References 29 publications

(32 reference statements)

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“…OS damages observed in endometriosis cells are localized in the proliferation process [126]. Superoxide dismutase activity is higher in endometriosis cells compared to healthy cells [127]. In endometriosis cells, OS can enhance the proliferation process [43] through the activation of MAPK/extracellular signal-regulated kinase (ERK), which acts on the proliferation and survival cell process.…”

Section: Curcumin and Oxidative Stressmentioning

confidence: 99%

Curcumin and Endometriosis

Vallée

Lecarpentier²

2020

IJMS

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Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

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Section: Curcumin and Oxidative Stressmentioning

confidence: 99%

Curcumin and Endometriosis

Vallée

Lecarpentier²

2020

IJMS

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“…A positive correlation between concentrations of tumor necrosis factor (TNF)-α in the peritoneal fluid and endometriosis has been reported [75]. Cytokines released by the macrophages influence the redox status of the ectopic endometrium in patients with endometriosis [81]. Superoxide dismutase, glutathione peroxidase activity and lipid peroxidation levels were measured in ectopic endometrial tissue obtained from ovarian endometriomas.…”

Section: Reviewmentioning

confidence: 99%

Role of oxidative stress in female reproduction

Agarwal

Gupta

Sharma

2005

Reprod Biol Endocrinol

1,150

486

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In a healthy body, ROS (reactive oxygen species) and antioxidants remain in balance. When the balance is disrupted towards an overabundance of ROS, oxidative stress (OS) occurs. OS influences the entire reproductive lifespan of a woman and even thereafter (i.e. menopause). OS results from an imbalance between prooxidants (free radical species) and the body's scavenging ability (antioxidants). ROS are a double-edged sword -they serve as key signal molecules in physiological processes but also have a role in pathological processes involving the female reproductive tract. ROS affect multiple physiological processes from oocyte maturation to fertilization, embryo development and pregnancy. It has been suggested that OS modulates the age-related decline in fertility. It plays a role during pregnancy and normal parturition and in initiation of preterm labor. Most ovarian cancers appear in the surface epithelium, and repetitive ovulation has been thought to be a causative factor. Ovulationinduced oxidative base damage and damage to DNA of the ovarian epithelium can be prevented by antioxidants. There is growing literature on the effects of OS in female reproduction with involvement in the pathophsiology of preeclampsia, hydatidiform mole, free radical-induced birth defects and other situations such as abortions. Numerous studies have shown that OS plays a role in the pathoysiology of infertility and assisted fertility. There is some evidence of its role in endometriosis, tubal and peritoneal factor infertility and unexplained infertility. This article reviews the role OS plays in normal cycling ovaries, follicular development and cyclical endometrial changes. It also discusses OS-related female infertility and how it influences the outcomes of assisted reproductive techniques. The review comprehensively explores the literature for evidence of the role of oxidative stress in conditions such as abortions, preeclampsia, hydatidiform mole, fetal embryopathies, preterm labour and preeclampsia and gestational diabetes. The review also addresses the growing literature on the role of nitric oxide species in female reproduction. The involvement of nitric oxide species in regulation of endometrial and ovarian function, etiopathogenesis of endometriosis, and maintenance of uterine quiescence, initiation of labour and ripening of cervix at parturition is discussed. Complex interplay between cytokines and oxidative stress in the etiology of female reproductive disorders is discussed. Oxidant status of the cell modulates angiogenesis, which is critical for follicular growth, corpus luteum formation endometrial differentiation and embryonic growth is also highlighted in the review. Strategies to overcome oxidative stress and enhance fertility, both natural and assisted are delineated. Early interventions being investigated for prevention of preeclampsia are enumerated. Trials investigating combination intervention strategy of vitamin E and vitamin C supplementation in preventing preeclampsia are highlighted. Antioxidants are ...

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“…In this study, we investigated the effectivity of alpha-lipoic acid in the treatment of endometriosis, which is an antioxidant and anti-inflammatory drug that has never been experimented in the treatment of endometriosis. In previous studies, increased oxidative stress parameters have been found both in ectopic endometrial tissues and in peripheral blood samples in endometriosis [26][27][28]. Oxidative stress is one of the factors in the pathophysiology of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

Pınar

Karapınar

Özcan

et al. 2017

Fundamemntal Clinical Pharma

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To investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre- and post-treatment. Tumor necrosis factor alpha (TNF-α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF-α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha-lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti-inflammatory effects.

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Indices of Oxidative Stress in Eutopic and Ectopic Endometria of Women with Endometriosis

Cited by 41 publications

References 29 publications

Curcumin and Endometriosis

Curcumin and Endometriosis

Role of oxidative stress in female reproduction

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

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