Índice trabecular óseo y niveles de 25-hidroxivitamina D en las complicaciones microvasculares de la diabetes mellitus tipo 2

Asri, Meryam Maamar el; Rodrigo, Emilio; Flor, Sara Díaz-Salazar de la; Valdivieso, Stefanie Pini; Barrón, M. Carmen Ramos; Olmos, José M.; Hernández, José L.

doi:10.1016/j.medcli.2021.04.027

Cited by 4 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, higher glycated hemoglobin levels and a longer disease duration in patients with T2DM are related to lower TBS values, although the interference of abdominal soft tissue thickness should be considered when interpreting these findings [68,[71][72][73]. Moreover, diabetic microvascular disease may be linked to lower TBS [74]. TBS has been demonstrated to be an independent predictor for osteoporotic fractures [62][63][64].…”

Section: Trabecular Bone Scorementioning

confidence: 99%

Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review

Martínez‐Montoro

García-Fontana

et al. 2022

JCM

View full text Add to dashboard Cite

Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM). However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry (DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS), high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation, are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of conventional tools for the evaluation of bone fragility and review the current evidence on novel approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.

show abstract

Section: Trabecular Bone Scorementioning

confidence: 99%

Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review

Martínez‐Montoro

García-Fontana

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

Trabecular bone score and bone mineral density as indices of skeletal fragility in endogenous Cushing's syndrome

Boro,

Mannar,

Malhotra

et al. 2023

Clinical Endocrinology

View full text Add to dashboard Cite

Objective: Endogenous Cushing's syndrome (CS) is a known cause of secondary osteoporosis. Vertebral fractures (VFs) in endogenous CS may occur despite normal bone mineral density (BMD). Trabecular bone score (TBS) is a relatively new, noninvasive technique to assess bone microarchitecture. The objective of our study was to analyse the BMD and bone microarchitecture using TBS in endogenous CS and compare it with a group of age and sex-matched healthy controls, and also analyse the factors predicting BMD and TBS.Design: Cross-sectional study of cases and controls.Patients and measurements: We included 40 female patients with overt endogenous CS, out of which 32 were adrenocorticotropic hormone (ACTH)dependent CS and 8 were ACTH-independent. We also included 40 healthy, female controls. Both patients and controls were subjected to an assessment of biochemical parameters and BMD and TBS.Results: Patients with endogenous CS had significantly lower BMD at the lumbar spine, femoral neck, and total hip and significantly lower TBS than healthy controls (all p < .001), while no significant difference was noted in the distal radius BMD (p = .055). In endogenous CS, a large proportion of patients, n = 13 (32.5%) had normal BMD for age (BMD Z-score ≥ −2.0) with low TBS (L 1 -L 4 TBS ≤ 1.34). TBS correlated negatively with HbA1c (p = .006), and positively with serum T4 (p = .027). Conclusion: TBS should be considered an important complementary tool in additionto BMD for the routine assessment of skeletal health in CS. K E Y W O R D S bone microarchitecture, bone mineral density, cortisol, Cushing's syndrome, trabecular bone score 1 | INTRODUCTION Endogenous Cushing's syndrome (CS) is a relatively rare endocrine disease with an incidence of 3.2 cases per million population per year. 1 Previous studies have shown that both exogenous and endogenous glucocorticoid excess leads to an increased risk of fragility fractures. 2 The underlying mechanisms include excess cortisol mediating negative calcium balance with decreased calcium re-absorption from the gut and impaired conversion of 25-hydroxyvitamin D [25(OH)D] to its active form, calcitriol. Excess cortisol also

show abstract

Trabecular Bone Score (TBS) in Individuals with Type 2 Diabetes Mellitus: An Updated Review

Trandafir,

Sima,

Gheorghe

et al. 2023

JCM

View full text Add to dashboard Cite

Bone fragility is a complication of type 2 diabetes mellitus (T2DM) that has been identified in recent decades. Trabecular bone score (TBS) appears to be more accurate than bone mineral density (BMD) in diabetic bone disease, particularly in menopausal women with T2DM, to independently capture the fracture risk. Our purpose was to provide the most recent overview on TBS-associated clinical data in T2DM. The core of this narrative review is based on original studies (PubMed-indexed journals, full-length, English articles). The sample-based analysis (n = 11, N = 4653) confirmed the use of TBS in T2DM particularly in females (females/males ratio of 1.9), with ages varying between 35 and 91 (mean 65.34) years. With concern to the study design, apart from the transversal studies, two others were prospective, while another two were case-control. These early-post-pandemic data included studies of various sample sizes, such as: males and females (N of 245, 361, 511, and 2294), only women (N of 80, 96, 104, 243, 493, and 887), and only men (N = 169). Overall, this 21-month study on published data confirmed the prior profile of BMD-TBS in T2DM, while the issue of whether checking the fracture risk is mandatory in adults with uncontrolled T2DM remains to be proven or whether, on the other hand, a reduced TBS might function as a surrogate marker of complicated/uncontrolled T2DM. The interventional approach with bisphosphonates for treating T2DM-associated osteoporosis remains a standard one (n = 2). One control study on 4 mg zoledronic acid showed after 1 year a statistically significant increase of lumbar BMD in both diabetic and non-diabetic groups (+3.6%, p = 0.01 and +6.2%, p = 0.01, respectively). Further studies will pinpoint additive benefits on glucose status of anti-osteoporotic drugs or will confirm if certain glucose-lowering regimes are supplementarily beneficial for fracture risk reduction. The novelty of this literature research: these insights showed once again that the patients with T2DM often have a lower TBS than those without diabetes or with normal glucose levels. Therefore, the decline in TBS may reflect an early stage of bone health impairment in T2DM. The novelty of the TBS as a handy, non-invasive method that proved to be an index of bone microarchitecture confirms its practicality as an easily applicable tool for assessing bone fragility in T2DM.

show abstract

Índice trabecular óseo y niveles de 25-hidroxivitamina D en las complicaciones microvasculares de la diabetes mellitus tipo 2

Cited by 4 publications

References 29 publications

Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review

Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review

Trabecular bone score and bone mineral density as indices of skeletal fragility in endogenous Cushing's syndrome

Trabecular Bone Score (TBS) in Individuals with Type 2 Diabetes Mellitus: An Updated Review

Contact Info

Product

Resources

About