Indicators phenotype lymphocytes and basophils in children with asthma

Abstract

The aim of our research to examine the phenotype of lymphocytes and basophils in children with atopic asthma. Materials and methods. A total of 150 children aged 5 to 18 years: 130 patients with asthma, 20 children in the control group. Determines the level of the following indicators of lymphocytes and basophils: СD3+, CD4+, СD4+CD25+, CD19+CD23+, CD203с+, СD203с+CD63+, CD203с+IgE. Results. In the study of lymphocyte phenotype determined that the level of CD4+, СD4+CD25+, CD19+ lymphocytes had no statistically significant differences from the control group of children (p>0,05). The relative level of CD3+ lymphocytes was significantly different from the control group level (p<0,05), but was within the reference values. The level of CD203с+CD63+ basophils, CD203с+IgE was significantly higher in children with asthma than children in the control group (p<0,01), while the absolute level CD203c+ basophils had no significant differences. Conclusion. The findings of the study results suggest that children with asthma the level of activated basophils statistically higher, indicating their participation in the development of the disease.