Indicators of Preeclampsia in Correlation with Maternal Cytokines in Pregnancy

Abstract

Aim: the purpose of the actual study was to evaluate, in the third trimester of pregnancy, the relationship between the formation of anti-inflammatory IL-10 cytokine and several indicators of moderate and severe preeclampsia. Materials and methods: in the third trimester of gestation, examination of the biochemical markers of preeclampsia (PE) and maternal IL-10 levels was conducted in 100 women with pregnancies complicated by varying degrees of preeclampsia and in 100 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Patients with preeclampsia were categorized into moderate and severe preeclampsia groups according to the degree of preeclampsia. Logistic regression of the different parameters for the occurrence of severe preeclampsia analysis was used to determine the predictive value. Results: the regression analysis detected systolic blood pressure of 160 mmHg or higher, diastolic blood pressure of 100 mmHg or higher, persistent proteinuria in pregnancy, serum LDH concentration of 450 U/L or higher, and reduced serum concentrations of IL-10 as significant predictors of severe preeclampsia. Conclusion: significantly, lower IL-10 concentrations in maternal serum in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe form of preeclampsia.

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

“…Pregnancy results in changes to maternal metabolism, which can be influenced by environmental, genetic [ 1 ], and inflammatory factors [ 2 , 3 ]; the combination of these factors could result in altered gestational weight gain (GWG) [ 3 ] and/or an increased risk of developing gestational diabetes [ 4 ], preeclampsia [ 5 ], and pregnancy-induced hypertension [ 6 ], among others.…”