Indicators of Poor Prognosis of Acute Pericarditis

Imazio, Massimo; Cecchi, Enrico; Demichelis, Brunella; Ierna, Salvatore; Demarie, Daniela; Ghisio, Aldo; Pomari, Franco; Coda, Luisella; Belli, Riccardo; Trinchero, Rita

doi:10.1161/circulationaha.106.662114

Cited by 311 publications

(257 citation statements)

References 28 publications

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“…Female sex has been associated with complications in acute pericarditis. 14 We found female sex to be associated with mortality in univariate analysis but not in multivariate analysis. Increasing age, however, was an independent predictor of death.…”

Section: Discussionmentioning

confidence: 62%

“…In addition, because we included only hospitalized patients, our results may underrepresent patients with low-risk features who may have been treated without being admitted to the hospital. 14 Although we report on potential causative comorbidities, the nature of the present data does not allow a description of detailed etiologic studies. Also, because the prevalence of tuberculosis in northern Europe is very low, the present results may not be applicable worldwide.…”

Section: Discussionmentioning

confidence: 84%

“…32 We found an incidence rate of 3.3. per 100 000, which reflects the fact that we included only patients with acute pericarditis admitted to a hospital and excluded pericardiotomy-and myocardial infarction-caused disease. Because overdiagnosis of pericarditis is common, 14 we maximized the accuracy of real-life diagnosis by including patients who had been examined and diagnosed on the hospital ward. This, in addition to the fact that our data collection did not cover all of the smallest regional hospitals that treat cardiac patients, may result in underestimation of the absolute incidence rate of acute pericarditis.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis for viral/ idiopathic pericarditis is good, 12 but purulent and tuberculosis pericarditis have high mortality. 13 Female sex has been associated with complications after acute pericarditis, 14 but this little is known about the effect of age. We studied the associations of age and sex with occurrence of acute pericarditis in allcomer adult patients using a multihospital, nationwide setting.…”

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confidence: 99%

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Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

2014

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Background-The clinical profile with regard to sex and the influences on outcomes in patients who have been hospitalized for acute pericarditis is largely uncharacterized. Methods and Results-We studied all patients aged ≥16 years admitted to the hospital because of acute pericarditis (postpericardiotomy and myocardial infarction associated pericarditis were excluded). Data were collected from a Finnish national registry that included data on all cardiovascular admissions (670 409

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

2014

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“…All culture samples referred to the laboratory were qualified by quality control criteria; samples with the results of colonization or contamination were excluded. For determining transudate versus exudate, the chemistries in the pericardial fluids were compared to those in the blood, using Light's criteria (98% sensitivity, 72% specificity) [11]. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method, in accordance with the Clinical and Laboratory Standards Institute (CLSI)'s guidelines [12].…”

Section: Methodsmentioning

confidence: 99%

Bacterial pericarditis and antimicrobial resistance at the Tehran Heart Center, Iran

Anvari

Kianinejad

Boroumand

et al. 2015

J Infect Dev Ctries

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Introduction: When bacterial pericarditis is suspected, urgent pericardial drainage combined with intravenous antibacterial therapy is mandatory to avert devastating, life-threatening complications. There have been scanty results on antimicrobial susceptibility of common causative microorganisms of bacterial pericarditis; most studies had small sample sizes and were performed decades ago. Methodology: This prospective study surveyed the causative bacteria in infectious pericardial effusions and their antimicrobial susceptibility among 320 consecutive cardiac patients who underwent pericardiocentesis at Tehran Heart Center between 2007 and 2012, using the European Society of Cardiology (ESC)'s criteria. Results: Staphylococcus spp. (S. epidermidis, S. aureus, S. haemolyticus) were the main causative organisms isolated from cultures of pericardial effusion samples. Other causative organisms were Streptococcus spp., Enterococcus faecium, Pseudomonas aeruginosa, and Acinetobacter baumannii. In the cultures studied, 35% methicillin-resistant Staphylococcus epidermidis (MRSE) and 42.9% methicillinresistant Staphylococcus aureus (MRSA) were detected. The most effective antimicrobial agents in S. epidermidis were gentamicin, ciprofloxacin, and cefoxitin. Clindamycin was relatively effective. S. aureus was highly susceptible to clindamycin and erythromycin. In cases of S. haemolyticus infection, clindamycin, erythromycin, cefoxitin, and ciprofloxacin were effective antibiotics. Conclusions: In order to diminish the nascence and extension of antimicrobial-resistant pathogens, logical and optimized antimicrobial usage and monitoring in hospitals are highly recommended. It is incumbent on healthcare systems to determine current local resistance patterns by which to guide empiric antimicrobial therapy for specific infections and microorganism types.

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