This study investigates the improvement in the seismic performance of an archetype reinforced concrete (RC) frame due to varying structural retrofit levels. Specifically, the study attempts to map the increase of the displacement-based global ratio between capacity and life-safety demand (CDRLS) to the reduction of seismic fragility. Such a reduction is characterized by the shift of the median fragility for different structure-specific damage states (DSs). The considered structure does not conform to modern seismic design requirements, and it is retrofitted using various techniques. Advanced nonlinear models are developed for the archetype frame, accounting for potential failure mechanisms, including flexural, joint, and shear failure. Three common retrofitting techniques are investigated, namely RC jacketing, steel jacketing, and fiber-reinforced polymers (FRP) wrapping of columns and joints. Each technique is specifically designed and proportioned to achieve predefined performance objectives (i.e., performancetargeted retrofitting), thus generating many retrofit alternatives. The improvement in seismic performance for the retrofitted frames is first characterized by computing the global CDRLS, which can be obtained using nonlinear pushover analysis combined with the Capacity Spectrum Method. Subsequently, cloud-based nonlinear time-history analyses are performed to derive fragility relationships for the as-built and retrofitted configurations, monitoring the variation in the median fragility for all DSs. Finally, the global CDRLS increase due to retrofitting is correlated with the corresponding shift in the median fragility. A linear trend is found, and it is used accordingly to develop simple models that engineers can implement to provide reasonable estimates for such shift once the global CDRLS is known.