Indicators of Cytokine Activity and Beta-Endorphin Production Level in Arterial Hypertension Associated With Asthenic/Neurotic Disorders in Young Men Employed in Stressful Professions

Герцев, А. В.; Ищук, В. Н.; Закревский, Ю. Н.

doi:10.15789/1563-0625-2017-6-749-754

Med. immunol.

2017

DOI: 10.15789/1563-0625-2017-6-749-754

|View full text |Cite

Indicators of Cytokine Activity and Beta-Endorphin Production Level in Arterial Hypertension Associated With Asthenic/Neurotic Disorders in Young Men Employed in Stressful Professions

А. В. Герцев¹,

В. Н. Ищук²,

Ю. Н. Закревский³

Abstract: Герцев А.В. и др. Medical Immunology (Russia)/Meditsinskaya Immunologiya Медицинская Иммунология токинов (IL-4, IL-10), а также снижение β-эндорфина в крови. Кроме того, выявлены нарушения во взаимовлиянии между вегетативной нервной и иммунной системами у этих больных.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Gavriliouk¹,

Evsegneeva²,

Михин³

2020

RRP

View full text Add to dashboard Cite

Introduction: The study of indicators of innate immunity in patients with arterial hypertension in clinical trials makes it necessary to correct them in order to reduce vascular inflammation in arterial hypertension to prevent damage to target organs and development of cardiovascular complications. The aim of the study was to assess the effectiveness of antihypertensive therapy to correct indicators of innate immunity in patients with essential arterial hypertension. Materials and methods: Patients with essential arterial hypertension (EAH) (II stage, 3rd degree) were divided into 3 groups: the 1st group included the patients with hypertrophy of the left ventricular myocardium; the 2nd group included the patients with atherosclerotic vascular lesions; the 3rd group included the patients with chronic kidney disease. As an initial antihypertensive pharmacotherapy, all the patients with essential arterial hypertension were prescribed perindopril (5–10 mg/day) and amlodipine (5–10 mg/day). Results and discussion: Changes in innate immunity indices in patients with essential arterial hypertension (II stage, 3rd degree) are differentiated depending on the affected target organ. The antihypertensive pharmacotherapy with perindopril and amlodipine in patients with essential arterial hypertension has various corrective effects on impaired innate immunity, depending on the nature of target organ damage. Regardless of target organ damage, ноу antihypertensive therapy with perindopril and amlodipine does not affect the reduced functional and increased metabolic activities of peripheral blood neutrophils. Conclusion: The results obtained dictate the need for further clinical studies of other classes of antihypertensive drugs and their combinations in the correction of innate immunity indices in order to effectively prevent the progression of target organ damage. Graphical abstract

show abstract

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Gavriliouk¹,

Evsegneeva²,

Михин³

2020

RRP

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Indicators of Cytokine Activity and Beta-Endorphin Production Level in Arterial Hypertension Associated With Asthenic/Neurotic Disorders in Young Men Employed in Stressful Professions

Cited by 1 publication

References 0 publications

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Contact Info

Product

Resources

About