Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population

Renieri, Elisavet; Γούμενου, Μαρίνα; Kardonsky, D. A.; Veselov, Valery V.; Alegakis, Athanasios; Buha, Aleksandra; Tzatzarakis, Manolis; Nosyrev, Alexander E.; Rakitskii, Valerii N.; Kentouri, M.; Tsatsakis, Aristidis

doi:10.1016/j.fct.2019.03.027

Cited by 49 publications

(21 citation statements)

References 49 publications

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“…In our first case study the six “indicator” non-dioxin-like polychlorinated biphenyls (NDL-PCBs) set from various international bodies such as the European Commission [28] for sea monitoring, were measured in fish from Greek seas [29]. Our aim was to evaluate the risk to the Greek population from exposure to these NDL-PCBs through fish consumption only, excluding all other food items.…”

Section: Case Studiesmentioning

confidence: 99%

Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQS) and Hazard Index (HIS) and the adversity specific Hazard Index (HIA)

2019

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A hazard quotient (HQ) for a single chemical and the hazard index (HI) for a mixture of chemicals were first described as approaches for risk characterisation by the EPA. HQ is defined as the ratio of exposure to an appropriate reference dose such as the ADI. HI is the sum of the HQs of the chemicals in a mixture. HQ and HI have been used to characterise risk after various exposure scenarios. However, both approaches have a significant limitation in the way they are used. The accurate use of HQ or HI requires estimation of aggregate exposure, that is, exposure to a given chemical(s) from all possible relevant sources. In many studies, risk is assessed assuming exposure from a specific source such as, consumption of water or a specific food item, in which chemical(s) concentration(s) have been measured. In this case the classic HQ/HI approach can result in significant underestimation of risk. For this purpose, we developed an alternative approach, named as Source Related HQ (HQs) where HQ S is the ratio of the exposure from the specific source of interest to the respected reference values. According to our approach the HQ S , before being compared to the reference dose, should be adjusted by a correction factor, in order to simulate aggregated exposure. A correction factor can be calculated based on the permitted exposure contribution from the specific source to the permitted aggregated exposure. Another important limitation specific to the HI approach is the use of chemical specific ADIs that do not correspond to the same critical effect. In this study, we present an analysis based on the individual critical effects, in order to derive the critical effect and an adversity specific Hazard Index (HI A ) and risk characterisation for the whole mixture.

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Section: Case Studiesmentioning

confidence: 99%

Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQS) and Hazard Index (HIS) and the adversity specific Hazard Index (HIA)

2019

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“…RLRS approach refers to the necessity of assessing health risk under real-life conditions such as long-term exposure to combinations of chemical and non-chemical stimuli in low doses [ 3 , 4 ]. Under the frame of the RLRS approach a number of studies, testing approaches, and methodologies are already published [ [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] ]…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole

et al. 2020

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“…PCB118 is highly toxic in vitro or in vivo and also in environmental residues (Zhang, Song, & Li, 2019). The sum of seven congeners (PCBs 28, 52, 101, 118, 138, 153 and 180) is often used as an indicator to evaluate the total amount of PCBs in the environment and PCB118 is the only DL‐PCBs among them (Renieri et al, 2019). It has been shown that exposure to a mixture of PCB118 and PCB101 during pregnancy or lactation can cause damage to the reproductive system of mice offspring, and this effect may continue into the next generation (Pocar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of intrauterine exposure to 2,3′,4,4′,5‐pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring

Lyu

Wang

et al. 2020

J of Applied Toxicology

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Polychlorinated biphenyls (PCBs) are a class of persistent organic environmental pollutants with a total of 209 homologs. The homolog 2,3′,4,4′,5‐pentachlorobiphenyl (PCB118) is one of the most important dioxin‐like PCBs and is highly toxic. PCB118 can accumulate in human tissues, serum and breast milk, which leads to direct exposure of the fetus during development. In the present study, pregnant mice were exposed to 0, 20 and 100 μg/kg/day of PCB118 during the stage of fetal primordial germ cell migration. Compared with the control group, we found morphological alterations of the seminiferous tubules and a higher sperm deformity rate in the male offspring in the treatment groups. Furthermore, the methylation patterns in the treatment groups of the imprinted genes H19 and Gtl2 in the sperm were altered in the male offspring. We also characterized the disturbance of the expression levels of DNA methyltransferase 1 (Dnmt1), Dnmt3a, Dnmt3b, Dnmt3l, and Uhrf1. The results indicated that intrauterine exposure to low doses of PCB118 could significantly damage the reproductive health of the male offspring. Therefore, attention should be paid to the adverse effects of PCB118 exposure during pregnancy on the reproductive system of male offspring.

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Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population

Cited by 49 publications

References 49 publications

Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQS) and Hazard Index (HIS) and the adversity specific Hazard Index (HIA)

Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQS) and Hazard Index (HIS) and the adversity specific Hazard Index (HIA)

Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole

Effects of intrauterine exposure to 2,3′,4,4′,5‐pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring

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