The trace element composition of detrital magnetite grains recovered from six local streams around the Casino high-grade porphyry Cu-Au-Mo deposit, west-central Yukon, is compared with igneous and magmatic-hydrothermal magnetite recovered from mineralized and unmineralized host rocks at the deposit. Linear discriminant analysis of 12 elements (Mg, Al, Ti, V, Mn, Co, Cr, Ni, Cu, Zn, Ga and Ge) and plots of Ti versus Ni/Cr are used to discriminate between magmatic-hydrothermal magnetite from the potassic alteration zone and igneous magnetite from granodiorite and quartz monzonite hosting the deposit. Magmatic-hydrothermal magnetite with a trace element composition similar to that from the potassic alteration zone at Casino is identifiable in stream sediments draining the deposit. Copper in magmatic-hydrothermal magnetite, present as minute inclusions of sulfide minerals such as chalcopyrite or substituted within the magnetite crystal lattice, is a strong indicator of Cu mineralization. We show that the chemical compositions of magnetite recovered from stream sediments can be used to explore for porphyry systems.Thematic collection: This article is part of the Applications of Innovations in Geochemical Data Analysis collection available at: https://www.lyellcollection.org/cc/applications-of-innovations-in-geochemical-data-analysisSupplementary material:https://doi.org/10.6084/m9.figshare.c.5896900